scholarly journals HIPERGLIKEMIA PADA ANAK DENGAN DIAGNOSIS DIABETES MELLITUS TYPE-1 , DIFERENTIAL DIAGNOSTIC MATURITY ONSET DIABETES OF THE YOUNG (MODY)

2018 ◽  
Vol 14 (2) ◽  
Author(s):  
Diah Hermayanti ◽  
Erlin Nursiloningrum
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes

Pendahuluan Diabetes mellitus (DM) merupakan penyakit metabolik ditandai oleh hiperglikemia yang disebabkan berkurangnya produksi atau kerja insulin. DM dapat menyerang anak-anak. Kami melaporkan kasus hiperglikemia pada anak berusia 9 tahun dengan kadar C-peptida dalam batas normal.KasusAnak perempuanberusia 9 tahun, dibawa ke rumah sakit dikeluhkan lemah badan selama satu minggu. Pasien juga dikeluhkan sering kencing terutama di malam hari selama sebulan dan bekas kencing dirubung oleh semut. Pemeriksaan fisik dalam batas normal. Pemeriksaan laboratorium hari pertama : hemoglobin 14,8 g/dl, leukosit 9.860 sel/ul, trombosit 297.000 sel/ul, gula darah acak 328 mg/dl. Pemeriksaan hari kedua : gula darah puasa 274 mg/dl, gula darah 2 jam post prandial 370 mg/dl, dan glukosuria. Pemeriksaan C-Peptida 2,74 ng/ml (normal 1,1 – 4,4 ng/ml)PembahasanPada pasien anak ini ditemukan gejala khas diabetes yaitu fatigue dan poliuri. Pada pemeriksaan laboratorium didapatkan hiperglikemia. Sesuai dengan pedoman dari PERKENI pasien ini didiagnosis sebagai DM, yaitu tipe-1, dengan diferential diagnosis Maturity onset diabetes of the young (MODY) mengingat kadar C-peptida dalam batas normal.  DM tipe 1 disebabkan oleh karena kerusakan  sel beta pankreas akibat adanya autoantibodi terhadap pankreas. Sedangkan MODY disebabkan oleh mutasi genetik pada sel β pankreas sehingga terjadi inefektifitas produksi atau gangguan pelepasan insulin. Pemeriksaan tambahan seperti deteksi antibodi sel islet disarankan untuk menetapkan diagnosis DM tipe 1, dan pemeriksaan genetik untuk mendeteksi terjadinya mutasi sel β pankreas.SimpulanDiagnosis Type-1 Diabetes mellitus, dengan diagnosis banding Maturity onset diabetes of the young(MODY)Kata Kunci: hiperglikemia anak, C-peptida, Diabetes mellitus tipe-1, MODY

A case of Type-1 diabetes mellitus formerly diagnosed as maturity-onset diabetes of the young (MODY) carrying suggestive MODY3 gene

1997 ◽  
Vol 38 (2) ◽  
pp. 139-141 ◽  
Author(s):  
Junnosuke Miura ◽  
Mayumi Sanaka ◽  
Yoko Ikeda ◽  
Chizuru Watanabe ◽  
Tomoko Nakagami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes

scholarly journals Variability of glycemia and cognitive impairment in patients with diabetes mellitus type 1.

2018 ◽  
Vol 96 (8) ◽  
pp. 741-745
Author(s):  
Yu. G. Samoylova ◽  
M. V. Matveeva ◽  
N. G. Zhukova ◽  
M. A. Rokank
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Type 1 Diabetes Mellitus ◽  
Cognitive Functions ◽  
Risk Index ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
The Relationship

Diabetes mellitus type 1 is associated with impaired cognitive function. Based on the results of systematic reviews and meta-analyzes, the most likely modifiable risk factor is the degree of metabolic control, in particular the variability of glycemia. Aims: to determine the influence of the variability of glycemia on cognitive functions in patients with type 1 diabetes mellitus. Material and methods. Design-observational, one-stage, cross-sectional research. We examined 30 patients with type 1 diabetes mellitus who were divided into 2 groups: 1 group (main) with cognitive impairment, and 2 (control) with normal cognitive functions. All patients were screened for cognitive functions using the Montreal scale (MoCa test). For the diagnosis of fluctuations in glucose level, continuous monitoring of glycemia was carried out using the iPro-2 device (Medtronic, USA): mean glycemic mean (MEAN), standard deviation (SD), mean amplitude of glycemic fluctuation (MAGE), long-term glycemic index (CONGA) Glycemia lability index (LI), hypoglycemia risk index (LBGI), hyperglycemia risk index (HBGI), mean hourly rate of glycemic change (MAG). Results. The study revealed that in patients with type 1 diabetes mellitus, cognitive impairment was dominated by a violation of constructive praxis, memory and attention. Recorded a significant difference in MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue and MAG. Correlation analysis revealed the relationship of cognitive impairments with the level of HbA1c, as well as the variability parameters MEAN, SD, CONGA, Gindex, LBGI, HBGI, MAGE, Mvalue, MAG. Conclusions. The relationship between the variability of glycemia and cognitive impairment was registered in patients with type 1 diabetes mellitus

scholarly journals Diabetes Mellitus Type-1 and Psychosocial Intervention to Improve Quality of Life

2021 ◽  
Vol 1 (4) ◽  
pp. 80-85
Author(s):  
Sarah Amalia
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Self Control ◽  
Comprehensive Treatment

Type 1 diabetes mellitus is the most common chronic endocrine pathology among children. Data from the Indonesian Pediatric Association (IDAI) states that the incidence of DM in children aged 0-18 years has increased by 700% over a period of 10 years. Treatment includes diet, physical activity, insulin medication, and proper self-control. The necessary changes in habits and lifestyles can lead to psychosocial problems, including anxiety, depression and eating disorders. Subsequently, the child or adolescent and his or her family group may move into new balance characterized by good self-control and adherence to treatment, or deepen individual and group disorders which may reappear, especially in adolescence. The comprehensive treatment of type 1 diabetes mellitus requires addressing these aspects through multidisciplinary teams which include medical and psychosocial professionals. This review analyses the main aspects related to the psychosocial impact of diabetes mellitus type 1 among children, adolescents and their families mental. A substantial amount of behavioral science research has demonstrated that psychosocial factors play an integral role in the management of diabetes in both children and adults. Research has also shown how psychosocial therapies that can improve regimen adherence, glycemic control, psychosocial functioning, and quality of life.

scholarly journals Characteristics of cognitive function in patients with diabetes mellitus type 1 younger depending transferred hypoglycemic conditions

2017 ◽  
pp. 17-21
Author(s):  
N. Zherdоva ◽  
B. Mankovsky
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Type 1 Diabetes Mellitus ◽  
Depression Scale ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Patients With Diabetes

Many studies focus on the effect of compensation of diabetes, glucose-lowering therapy of choice, the influence of cardio - vascular diseases in the state of cognition. At the same time, not enough attention is paid to cognitive impairment in patients with type 1 diabetes mellitus, especially young people. The aim of our study was to investigate the prognostic factors of dementia in patients with type 1 diabetes mellitus are younger. 33 patients were examined with type 1 diabetes and 10 people in the control group. Of the 33 patients with diabetes, 21 people had hypoglycemia in the last 3 months and 12 without hypoglycemic states. To identify depression used two questionnaires: Centre for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HAD). Evaluation of cognitive impairment was conducted using the following methods: The test "5 words", sample Schulte, the scale of assessment of mental status ( MMSE), test battery on the frontal dysfunction (BLD), evaluation of test o’clock. To reveal the 10-year risk of dementia patients used the scale which was developed by a team of researchers at Utrecht University Medical Rudolf Magnus. In patients with type 1 diabetes with hypoglycemia marked deterioration in cognitive function, according to the neuropsychological tests, namely the BLD and MMSE compared with  patient without hypoglycemia. The risk of developing dementia over 10 years in patients with diabetes mellitus type 1 young up 2.2 times compared with patients without hypoglycemia. Hypoglycemic state is the main risk factor that leads to the development of cognitive impairment, and this is a factor which can be influenced by insulin properly selected.

Diabetes Mellitus Type-1 and Psychosocial Intervention to Improve Quality of Life

2021 ◽  
Vol 1 (4) ◽  
pp. 80-85
Author(s):  
Sarah Amalia
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Self Control ◽  
Comprehensive Treatment

Type 1 diabetes mellitus is the most common chronic endocrine pathology among children. Data from the Indonesian Pediatric Association (IDAI) states that the incidence of DM in children aged 0-18 years has increased by 700% over a period of 10 years. Treatment includes diet, physical activity, insulin medication, and proper self-control. The necessary changes in habits and lifestyles can lead to psychosocial problems, including anxiety, depression and eating disorders. Subsequently, the child or adolescent and his or her family group may move into new balance characterized by good self-control and adherence to treatment, or deepen individual and group disorders which may reappear, especially in adolescence. The comprehensive treatment of type 1 diabetes mellitus requires addressing these aspects through multidisciplinary teams which include medical and psychosocial professionals. This review analyses the main aspects related to the psychosocial impact of diabetes mellitus type 1 among children, adolescents and their families mental. A substantial amount of behavioral science research has demonstrated that psychosocial factors play an integral role in the management of diabetes in both children and adults. Research has also shown how psychosocial therapies that can improve regimen adherence, glycemic control, psychosocial functioning, and quality of life.

Onset of type 1 diabetes mellitus in two patients with maturity onset diabetes of the young

2011 ◽  
Vol 13 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Giulio Maltoni ◽  
Stefano Zucchini ◽  
Mirella Scipione ◽  
Vilma Mantovani ◽  
Silvana Salardi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Maturity Onset Diabetes ◽  
Onset Diabetes

scholarly journals Evaluation of Vascular Endothelial Function in Children with Type 1 Diabetes Mellitus

2021 ◽  
Vol 10 (21) ◽  
pp. 5065
Author(s):  
Karolina Nocuń-Wasilewska ◽  
Danuta Zwolińska ◽  
Agnieszka Zubkiewicz-Kucharska ◽  
Dorota Polak-Jonkisz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Linear Correlations ◽  
Pai 1

Diabetic kidney disease belongs to the major complications of diabetes mellitus. Here, hyperglycaemia is a key metabolic factor that causes endothelial dysfunction and vascular changes within the renal glomerulus. The aim of the present study was to assess the function of the vascular endothelium in children with type 1 diabetes mellitus (type 1 diabetes) by measuring selected endothelial lesion markers in blood serum. The selected markers of endothelial lesions (sVCAM-1, sICAM-1, sE-SELECTIN, PAI-1, ADMA and RAGE) were assayed by the immunoenzymatic ELISA method. The study involved 66 patients (age: 5–18 years) with type 1 diabetes and 21 healthy controls (age: 5–16 years). In the type 1 diabetes patients, significantly higher concentrations of all of the assayed markers were observed compared to the healthy controls (p < 0.001). All of the evaluated markers positively correlated with the disease duration, the age, and BMI of the patients, while only PAI-1 and sE-SELECTIN were characteristic of linear correlations with the estimated glomerular filtration rate (eGFR). It can be concluded that endothelial inflammatory disease occurs in the early stages of type 1 diabetes mellitus in children. The correlations between PAI-1, sE-SELECTIN, and eGFR suggest an advantage of these markers over other markers of endothelial dysfunction as prognostic factors for kidney dysfunction in children with type 1 diabetes.

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