Assessment of peridontal vessels hemodynamics  among patients with diabetes mellitus type 1

Relevance. Processes of disturbance of regional hemodynamics, tissue blood flow, insufficiency of transcapillary metabolism and antioxidant system caused by dysfunction of periodontal vascular endothelium among patients with diabetes type 1 directly lead to diabetic microangiopathy accompanied by decrease of level of microcirculation and perfusion of periodontal tissues among patients with absolute insulin insufficiency. The reduction of linear and volumetric blood flow rates in periodontal vessels among patients with type 1 diabetes compared to values obtained by ultrasonic dopplerography in healthy patients can be considered as distinctive features of the manifestation of this systemic disease on microcirculation of periodontal tissues.Purpose. To evaluate the hemodynamics of periodontal vessels among patients with diabetes mellitus type 1 and without diabetes before and after conservative periodontal therapy.Materials and methods. 40 patients at the age 20-30 years were surveyed: 20 patients with diabetes mellitus type 1 and 20 patients without diabetes. All subjects underwent dental examination. To study the state of microcirculation of periodontal tissues patients of both groups underwent high-frequency ultrasound Doppler “Minimax-doppler-k”. Further was conducted professional oral hygiene complex with training in rules of individual oral hygiene. Reexamination was scheduled after 4 weeks. Results. During the conduction have been registered average baseline of the linear (Vam) and volumetric (Qam) blood flow in periodontal vessels in patients with diabetes mellitus type 1 and without diabetes. Average linear (Vam) and volumetric (Qam) blood flow before the conduction of professional oral hygiene complex were considerably lower compared to patients without diabetes. This points reduction of microcirculation and perfusion of periodontal tissues in patients with diabetes mellitus type 1 and without diabetes. Reassessment of blood flow in periodontal tissues in 4 weeks after professional oral hygiene revealed an increase in rate of microcirculation in periodontal tissues among patients with diabetes mellitus type 1 and without diabetes. Conclusion. Our study confirms the theory of hemodynamic impairment and local hemostasis in patients with type 1 diabetes, which is reflected in the appearance of trophic disorders of an inflammatory-dystrophic nature and a decrease in hemodynamic parameters. After conservative periodontal therapy, we revealed positive changes in hemodynamics of periodontal vessels, which was recorded using ultrasound dopplerography. Our results will allow us to select the optimal algorithms for the timely diagnosis, prevention and treatment of dental diseases in patients with type 1 diabetes in future.

Download Full-text

Analysis of anti-inflammatory toothpastes efficiency among patients with diabetes mellitus and chronic generalized periodontitis

Periodontology ◽

10.33925/1683-3759-2020-25-1-47-53 ◽

2020 ◽

Vol 25 (1) ◽

pp. 47-53

Author(s):

L. Yu. Orekhova ◽

R. S. Musaeva ◽

E. S. Loboda ◽

E. V. Grinenko ◽

A. V. Chuprinina ◽

...

Keyword(s):

Diabetes Mellitus ◽

Oral Cavity ◽

Oral Hygiene ◽

Periodontal Diseases ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Periodontal Tissues ◽

Patients With Diabetes ◽

Anti Inflammatory

Relevance. Inflammatory periodontal diseases (IPD) on the background of microangiopathy among patients with diabetes mellitus (DM) are considered one of the main complications. Reduced resistance of periodontal tissues and trophic disorders due to changes in capillary walls leads to development of inflammatory processes with the destruction of gingival joint. The presence of diabetes mellitus in patients with chronic generalized periodontitis requires not only conservative periodontal therapy by a dentist, but also constant maintenance therapy, which consists in the ability of patient to maintain satisfactory oral hygiene and the use of therapeutic and prophylactic toothpastes.Purpose. To evaluate the effectiveness of using toothpastes with anti-inflammatory components among pa-tients with chronic generalized periodontitis and type 1 diabetes after professional oral hygiene complex.Materials and methods. The examination of 60 patients with diabetes mellitus type 1 and chronic generalized periodontitis at the age of 20 to 50 years was conducted. All patients underwent a questionnaire on the presence of complaints about state of the oral cavity and a comprehensive dental examination with definition of basic dental indices. Then, a complex of professional oral hygiene with individual hygiene training was carried out. Patients were divided into groups depending on the prescribed paste with anti-inflammatory components. Repeated examination was carried out after 1 month.Results. In 1 month after conservative therapy was carried out, improvement of all indexes in all groups, improvement of the acid-base state of the oral fluid was found. Patients themselves noted a better way change in state of oral cavity tissues. The best dynamics after treatment complex was observed in the 1st group.Conclusion. Hygienic and periodontal condition of the oral cavity among patients with diabetes mellitus type 1 was initially at a rather low level. It has been revealed that complex of professional oral hygiene and prescription of therapeutic and prophylactic toothpaste improve periodontal status of patients with diabetes.

Download Full-text

Characteristics of cognitive function in patients with diabetes mellitus type 1 younger depending transferred hypoglycemic conditions

East European Journal of Neurology ◽

10.33444/2411-5797.2017.1(13).17-21 ◽

2017 ◽

pp. 17-21

Author(s):

N. Zherdоva ◽

B. Mankovsky

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Cognitive Impairment ◽

Cognitive Function ◽

Type 1 Diabetes Mellitus ◽

Depression Scale ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Patients With Diabetes

Many studies focus on the effect of compensation of diabetes, glucose-lowering therapy of choice, the influence of cardio - vascular diseases in the state of cognition. At the same time, not enough attention is paid to cognitive impairment in patients with type 1 diabetes mellitus, especially young people. The aim of our study was to investigate the prognostic factors of dementia in patients with type 1 diabetes mellitus are younger. 33 patients were examined with type 1 diabetes and 10 people in the control group. Of the 33 patients with diabetes, 21 people had hypoglycemia in the last 3 months and 12 without hypoglycemic states. To identify depression used two questionnaires: Centre for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HAD). Evaluation of cognitive impairment was conducted using the following methods: The test "5 words", sample Schulte, the scale of assessment of mental status ( MMSE), test battery on the frontal dysfunction (BLD), evaluation of test o’clock. To reveal the 10-year risk of dementia patients used the scale which was developed by a team of researchers at Utrecht University Medical Rudolf Magnus. In patients with type 1 diabetes with hypoglycemia marked deterioration in cognitive function, according to the neuropsychological tests, namely the BLD and MMSE compared with patient without hypoglycemia. The risk of developing dementia over 10 years in patients with diabetes mellitus type 1 young up 2.2 times compared with patients without hypoglycemia. Hypoglycemic state is the main risk factor that leads to the development of cognitive impairment, and this is a factor which can be influenced by insulin properly selected.

Download Full-text

The condition of mammary glands in women with diabetes mellitus type 1

Journal of obstetrics and women s diseases ◽

10.17816/jowd67338-43 ◽

2018 ◽

Vol 67 (3) ◽

pp. 38-43

Author(s):

Ekaterina V. Musina ◽

Igor Yu. Kogan ◽

Natalia V. Borovik

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Mammary Gland ◽

Mammary Glands ◽

Diabetes Mellitus Type 1 ◽

Diabetes Mellitus Type ◽

Diabetic Mastopathy ◽

Fibrocystic Mastopathy ◽

Patients With Diabetes

Background. The pathogenesis of diabetic mastopathy is unknown. It is assumed that one of the important factors in the development of this disease may be hyperglycemia. The aim of this study was to evaluate the clinical manifestations and echographic features of the mammary gland structure in women with diabetes mellitus type 1. Materials and methods. The three groups of women were examined: group 1: women with type 1 diabetes, with the onset of the disease before menarche (n = 58); group 2: women with type 1 diabetes, with the onset of the disease after menarche (n = 56); group 3: women with fibrocystic mastopathy, without diabetes mellitus type 1 (n = 79). Mastalgia was evaluated using the visual analogue scale. The ultrasound examination of mammary glands was performed on day 5 to 7 of the menstrual cycle. Results. The patients of all groups complained of mastalgia. Mammary gland ultrasound revealed that the thickness of the glandular tissue in patients of the first group was significantly less than in the second and third group. The diameter of the milk ducts was also significantly different in patients in each study group. In the group of patients with fibrocystic mastopathy without diabetes mellitus type 1, the tissue echogenicity is average in 41.8% of subjects, with it elevated in 58.2% of individuals. Moreover, in groups of patients with diabetes, 90% of subjects have increased echogenicity of breast tissue. Conclusion. Diabetic mastopathy is characterized by a fibrotic echo version of the organ parenchyma, which can be caused by a violation of the mammary gland formation and function in patients with diabetes mellitus type 1.

Download Full-text