scholarly journals Exposure to pesticides and digestive system cancers: systematic review and meta-analysis

2021 ◽  
Vol 10 (11) ◽  
pp. e06101119163
Author(s):  
Iago Sávyo Duarte Santiago ◽  
Estelita Lima Cândido ◽  
Lucas Farias Lopes ◽  
João Pedro Leite de Medeiros Almeida ◽  
Cláudio Gleidiston Lima da Silva
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Systematic Review ◽  
Binary Data ◽  
Digestive System ◽  
Meta Analysis ◽  
Continuous Data ◽  
Positive Evidence ◽  
Pubmed Database

Pesticides are substances often described as carcinogenic initiators for some neoplasms, such as lympho-hematopoietic and breast cancer. As for cancer of the digestive system, this relationship is still poorly explored and requires more evidence. A systematic review with meta-analysis was conducted on the association between pesticides and cancer of the digestive system in the PUBMED database. Of the 567 papers found, 32 were approved for qualitative analysis and seven for meta-analysis. Hexachlorobenzene and DDT were significantly associated with colorectal cancer (MD: 15.92; CI: 6.45; 25.40) in the analysis of continuous data and showed a borderline association in the analysis of binary data (OR: 1.17; CI: 0.93; 1.47). The cyclodienes family showed similar results in both analyzes. Polychlorinated biphenyls with low dosages were also associated with colorectal cancer (MD: 38.95; CI: 12.78; 65.11). Organophosphates (OR: 0.54; 95% CI: 0.29; 0.98), carbamates (OR: 0.96; CI: 0.77; 1.21) and triazines (OR: 0.91; 95% CI: 0.74; 1.13) showed inconclusive results. This review presents positive evidence for the association of pesticides with colorectal cancer. However, more evidence is required to determine the role of pesticides in the development of other cancers of the digestive system.

The role of LHRH agonists in ovarian function preservation in premenopausal women undergoing chemotherapy for early stage breast cancer: A systematic review and meta-analysis.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1050-1050
Author(s):  
Rodrigo Ramella Munhoz ◽  
Allan Andresson Lima Pereira ◽  
Andre Deeke Sasse ◽  
Paulo Marcelo Hoff ◽  
Tiffany A. Traina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Ovarian Function ◽  
Early Stage ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Early Stage Breast Cancer ◽  
Lhrh Agonists ◽  
Function Preservation

Dietary phytoestrogens and biomarkers of their intake in relation to cancer survival and recurrence: a comprehensive systematic review with meta-analysis

2020 ◽  
Vol 79 (1) ◽  
pp. 42-65 ◽  
Author(s):  
Agnieszka Micek ◽  
Justyna Godos ◽  
Tomasz Brzostek ◽  
Agnieszka Gniadek ◽  
Claudia Favari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Systematic Review ◽  
Cancer Survival ◽  
Data Extraction ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Inverse Association ◽  
Blood Biomarkers ◽  
Cancer Specific Survival

Abstract Context Recent studies have outlined the potential role of dietary factors in patients who have survived cancer. Objective The aim of this study was to summarize the evidence of the relation between dietary intake of phytoestrogens and their blood biomarkers and, overall, cancer-specific mortality and recurrence in patients with cancer. Data Sources A systematic search of PubMed, EMBASE, and Web of Science databases of studies published up to September 2019 was performed. Databases were searched for prospective and retrospective cohort studies reporting on dietary phytoestrogen intake and/or blood biomarkers and the outcomes investigated. Data extraction Data were extracted from each identified study using a standardized form. Data analysis Twenty-eight articles on breast, lung, prostate, and colorectal cancer, and glioma were included for systematic review. Given the availability of studies, a quantitative meta-analysis was performed solely for breast cancer outcomes. A significant inverse association among higher dietary isoflavone intake, higher serum/plasma enterolactone concentrations, and overall mortality and cancer recurrence was found. Among other cancer types, 2 studies reported that higher serum enterolactone and higher intake of lignans were associated with cancer-specific survival for colorectal cancer and glioma, respectively. Conclusions Dietary phytoestrogens may play a role in survival from breast cancer ; evidence regarding other cancers is too limited to draw any conclusions.

scholarly journals The Role of p-STAT3 as a Prognostic and Clinicopathological Marker in Colorectal Cancer: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160125 ◽  
Author(s):  
Kun Ji ◽  
Mingxuan Zhang ◽  
Qi Chu ◽  
Yong Gan ◽  
Hui Ren ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Meta Analysis
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