scholarly journals EFEKTIVITAS PEMBERIAN DOSIS TINGGI METHYLPREDNISOLONE PADA TRAUMA SPINAL CORD AKUT

2013 ◽  
Vol 2 (1) ◽  
pp. 81-85
Author(s):  
Abdul Qodir
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Additional Data ◽  
Spinal Cord Injuries ◽  
Acute Spinal Cord Injury ◽  
High Dose ◽  
High Dose Methylprednisolone ◽  
Cord Injury ◽  
Methylprednisolone Treatment ◽  
Language Data

Acute spinal cord injury is a devastating condition typically affecting young people, mostly males. High-Dose Methylprednisolone treatment in the early hours after the injury is aimed at reducing the extent of permanent paralysis during the rest of the patient’s life. The aim To review randomized trials of High-Dose Methylprednisolone in Acute Spinal Cord Injuries. All randomized controlled trials of steroid treatment for acute spinal cord injury in any language. Data have been extracted from original trial reports. For the NASCIS, Japanese and French trials, additional data (e.g. SDs) have been obtained from the original authors. The evidence produced by this systematic review support the use of high dose methylprednisolone in acute spinal cord injury to improve neurological recovery. Patients who received high-dose methylprednisolone therapy should be observed with intensive in order to reduce complications from such therapy.

scholarly journals High-dose methylprednisolone may cause myopathy in acute spinal cord injury patients

Spinal Cord ◽  
2004 ◽  
Vol 43 (4) ◽  
pp. 199-203 ◽  
Author(s):  
T Qian ◽  
X Guo ◽  
A D Levi ◽  
S Vanni ◽  
R T Shebert ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
High Dose ◽  
High Dose Methylprednisolone ◽  
Cord Injury

scholarly journals High-Dose Methylprednisolone for Acute Closed Spinal Cord Injury - Only a Treatment Option

2002 ◽  
Vol 29 (3) ◽  
pp. 227-235 ◽  
Author(s):  
H. Hugenholtz ◽  
D.E. Cass ◽  
M.F. Dvorak ◽  
D.H. Fewer ◽  
R.J. Fox ◽  
...  
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Treatment Option ◽  
Spinal Cord Injuries ◽  
High Dose ◽  
Cochrane Systematic Review ◽  
High Dose Methylprednisolone ◽  
Cord Injury ◽  
Level I

Background:A systematic review of the evidence pertaining to methylprednisolone infusion following acute spinal cord injury was conducted in order to address the persistent confusion about the utility of this treatment.Methods:A committee of neurosurgical and orthopedic spine specialists, emergency physicians and physiatrists engaged in active clinical practice conducted an electronic database search for articles about acute spinal cord injuries and steroids, from January 1, 1966 to April 2001, that was supplemented by a manual search of reference lists, requests for unpublished additional information, translations of foreign language references and study protocols from the author of a Cochrane systematic review and Pharmacia Inc. The evidence was graded and recommendations were developed by consensus.Results:One hundred and fifty-seven citations that specifically addressed spinal cord injuries and methylprednisolone were retrieved and 64 reviewed. Recommendations were based on one Cochrane systematic review, six Level I clinical studies and seven Level II clinical studies that addressed changes in neurological function and complications following methylprednisolone therapy.Conclusion:There is insufficient evidence to support the use of high-dose methylprednisolone within eight hours following an acute closed spinal cord injury as a treatment standard or as a guideline for treatment. Methylprednisolone, prescribed as a bolus intravenous infusion of 30 mg per kilogram of body weight over fifteen minutes within eight hours of closed spinal cord injury, followed 45 minutes later by an infusion of 5.4 mg per kilogram of bodyweight per hour for 23 hours, is only a treatment option for which there is weak clinical evidence (Level I- to II-1). There is insufficient evidence to support extending methylprednisolone infusion beyond 23 hours if chosen as a treatment option.

scholarly journals Administration of High-Dose Methylprednisolone Worsens Bone Loss after Acute Spinal Cord Injury in Rats

2021 ◽  
Vol 2 (1) ◽  
pp. 592-602
Author(s):  
Yuanzhen Peng ◽  
Wei Zhao ◽  
Yizhong Hu ◽  
X. Edward Guo ◽  
Jun Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Loss ◽  
Acute Spinal Cord Injury ◽  
High Dose ◽  
High Dose Methylprednisolone ◽  
Cord Injury

High-dose methylprednisolone for acute traumatic spinal cord injury

Neurology ◽  
2019 ◽  
Vol 93 (9) ◽  
pp. e841-e850 ◽  
Author(s):  
Zhongyu Liu ◽  
Yang Yang ◽  
Lei He ◽  
Mao Pang ◽  
Chunxiao Luo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adverse Events ◽  
Observational Studies ◽  
Hospital Costs ◽  
Acute Spinal Cord Injury ◽  
Current Evidence ◽  
High Dose ◽  
High Dose Methylprednisolone ◽  
Cord Injury

ObjectiveDue to the continuing debates on the utility of high-dose methylprednisolone (MP) early after acute spinal cord injury (ASCI), we aimed to evaluate the therapeutic and adverse effects of high-dose MP according to the second National Acute Spinal Cord Injury Study (NASCIS-2) dosing protocol in comparison to no steroids in patients with ASCI by performing a meta-analysis on the basis of the current available clinical trials.MethodsWe searched PubMed and Cochrane Library (to May 22, 2018) for studies comparing neurologic recoveries, adverse events, and in-hospital costs between ASCI patients who underwent high-dose MP treatment or not. Data were synthesized with corresponding statistical models according to the degree of heterogeneity.ResultsWe enrolled 16 studies (1,863 participants) including 3 randomized controlled trials (RCTs) and 13 observational studies. Pooled results indicated that MP was not associated with an increase in motor score improvement (RCTs: p = 0.84; observational studies: p = 0.44) and incidence of recovery by at least one grade on the American Spinal Injury Association Impairment Scale or Frankel (p = 0.53). Meanwhile, MP did not lead to better sensory recovery (p = 0.07). However, MP was associated with a significantly higher incidence of gastrointestinal hemorrhage (p = 0.04) and respiratory tract infection (p = 0.01). The difference in the overall in-hospital costs between MP and control groups was not statistically significant (p = 0.78).ConclusionsBased on the current evidence, high-dose MP treatment, in comparison to controls, does not contribute to better neurologic recoveries but may increase the risk of adverse events in patients with ASCI. Therefore, we recommend against routine use of high-dose MP early after ASCI.

Early complications of high-dose methylprednisolone in acute spinal cord injury patients

Injury ◽  
2008 ◽  
Vol 39 (7) ◽  
pp. 748-752 ◽  
Author(s):  
Borja Suberviola ◽  
Alejandro González-Castro ◽  
Javier Llorca ◽  
Fernando Ortiz-Melón ◽  
Eduardo Miñambres
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Acute Spinal Cord Injury ◽  
High Dose ◽  
Early Complications ◽  
High Dose Methylprednisolone ◽  
Cord Injury
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