Caroli's disease: hepatic arterial color doppler signals in the communicating dilated bile ducts

This article describes a case of Caroli’s disease in a 53-year-old female patient who complained nonspecificabdominal pain without cholestasis or cholangitis. Ultrasound and hepatic magnetic resonanceimaging showed segmental saccular dilations connected to intrahepatic bile ducts without hepaticfibrosis. This clinical case shows the possibility of having oligosymptomatic forms in the diffuse formsof Caroli disease, therefore the interest to consider this diagnosis in case of non-specific abdominalsigns and to request a hepatic ultrasound. Bangladesh J Medicine July 2020; 31(2) : 107-110

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Congenital Dilatation of the Bile Ducts (Caroli’s Disease) in Young Dogs

Journal of Veterinary Internal Medicine ◽

10.1892/0891-6640(2003)017<0028:cdotbd>2.3.co;2 ◽

2003 ◽

Vol 17 (1) ◽

pp. 28 ◽

Cited By ~ 2

Author(s):

S. Görlinger ◽

J. Rothuizen ◽

S. Bunch ◽

T.S.G.A.M. van den Ingh

Keyword(s):

Bile Ducts ◽

Caroli's Disease ◽

Caroli’S Disease

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Congenital Dilatation of the Intrahepatic Bile Ducts (Caroli's Disease)

Radiology ◽

10.1148/127.3.746 ◽

1978 ◽

Vol 127 (3) ◽

pp. 746-746 ◽

Cited By ~ 13

Author(s):

Javier Lucaya ◽

Jose Luis Gomez ◽

Ceferino Molino ◽

Juan Gonzalez Atienza

Keyword(s):

Bile Ducts ◽

Caroli's Disease ◽

Caroli’S Disease ◽

Intrahepatic Bile Ducts

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Caroli's disease (clinical observation)

Journal Infectology ◽

10.22625/2072-6732-2021-13-3-150-152 ◽

2021 ◽

Vol 13 (3) ◽

pp. 150-152

Author(s):

G. G. Kuttykuzhanova ◽

A. Zh. Tanirbergenova ◽

S. Zh. Abdirazakova ◽

Z. Zh. Urikbaeva

Keyword(s):

Early Diagnosis ◽

Rare Diseases ◽

Medical Practice ◽

Bile Ducts ◽

Clinical Observation ◽

Diagnostic Methods ◽

Caroli's Disease ◽

Caroli’S Disease ◽

Intrahepatic Stones ◽

Intrahepatic Bile Ducts

In their medical practice doctors deal with rare diseases which present difficulties in making a clinical diagnosis, in this case additional diagnostic methods are required. One of these diseases is Caroli's disease (syndrome), characterized by cystic enlargement of the intrahepatic bile ducts with frequent formation of intrahepatic stones. Taking into account the difficulties of early diagnosis, we present our own observation.

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Congenital dilatation of the large and segmental intrahepatic bile ducts (Caroli's disease) in two Golden retriever littermates : clinical communication

Journal of the South African Veterinary Association ◽

10.4102/jsava.v77i4.379 ◽

2006 ◽

Vol 77 (4) ◽

Cited By ~ 11

Author(s):

R.D. Last ◽

J.M. Hill ◽

M. Roach ◽

T. Kaldenberg

Keyword(s):

Bile Ducts ◽

Autosomal Recessive ◽

Autosomal Recessive Inheritance ◽

Golden Retriever ◽

Portal Fibrosis ◽

Clinical Communication ◽

Caroli's Disease ◽

Caroli’S Disease ◽

Intrahepatic Bile Ducts ◽

Collecting Ducts

Two, sibling, male Golden retriever puppies, 13 weeks of age, were presented with congenital biliary cysts of the liver involving both hepatic and segmental bile ducts, as well as bilateral polycystic kidney disease. Ultrasonography of the livers of both pups demonstrated segmental cystic lesions that were contiguous with the bile ducts. Histopathology revealed cystic ectatic bile duct hyperplasia and dysplasia with variable portal fibrosis in the liver, while in the kidneys there were radially arranged, cylindrically dilated cysts of the collecting ducts, which extended through the medulla and cortex. This pathology was compatible with that of congenital dilatation of the large and segmental bile ducts (Caroli's disease) described in humans, dogs and rats. In humans Caroli's disease has an autosomal recessive inheritance pattern, while in rats activation of the MEK5/ERK cascade initiates the biliary dysgenesis of Caroli's disease in this species. However, the exact mode of inheritance and pathogenesis of Caroli's disease in dogs is as yet unknown. Previous reports on congenital hepatic cystic diseases of the dog have described Caroli's disease like lesions in various breeds, but these are believed to be the 1st reported cases in the Golden retriever breed.

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Monolobar Form of Caroli’s Disease with Intrahepatic Stone (Clinical Case)

Medical Visualization ◽

10.24835/1607-0763-2017-2-85-89 ◽

2017 ◽

pp. 85-89

Author(s):

T. N. Galyan ◽

N. S. Tarba ◽

V. V. Khovrin ◽

L. O. Polizhuk ◽

N. N. Bagmet ◽

...

Keyword(s):

Sclerosing Cholangitis ◽

Bile Ducts ◽

Clinical Case ◽

Caroli's Disease ◽

Liver Segment ◽

Caroli’S Disease ◽

Intrahepatic Stones ◽

Intrahepatic Bile Ducts ◽

Polycystic Disease ◽

True Type

Caroli’s disease is a rare inherited disorder characterized by nonobstructive saccular or fusiform dilation of the intrahepatic bile ducts. Two main types of Caroli’s disease are reported, the true type with isolated dilation of intrahepatic bile ducts of single liver segment with formation of stones and development of cholangitis. The second type is combined with a congenital hepatic fibrosis. The true type of Caroli’s disease is distinct from primary sclerosing cholangitis, polycystic disease, cholangiolithiasis and other diseases. This paper presents a literature review and a case of monolobar Caroli’s disease with intrahepatic stones. The difficulties of preoperative differential diagnosis are shown.

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