scholarly journals Catalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels

2022 ◽  
Vol 63 (1) ◽  
pp. 56
Author(s):  
Yuxi Di ◽  
Mingfei Zhang ◽  
Yichang Chen ◽  
Ruonan Sun ◽  
Meiyu Shen ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Protein Levels ◽  
Cell Transdifferentiation

scholarly journals Identification of Novel Molecular Markers of Human Th17 Cells

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1611 ◽  
Author(s):  
Anna Sałkowska ◽  
Kaja Karaś ◽  
Iwona Karwaciak ◽  
Aurelia Walczak-Drzewiecka ◽  
Mariusz Krawczyk ◽  
...  
Keyword(s):  
Host Defense ◽  
Th17 Cell ◽  
Th17 Cells ◽  
Cathepsin L ◽  
Cell Type ◽  
Protein Levels ◽  
Pathological Conditions ◽  
Th17 Lymphocytes ◽  
New Information ◽  
Apolipoprotein D

Th17 cells are important players in host defense against pathogens such as Staphylococcus aureus, Candida albicans, and Bacillus anthracis. Th17 cell-mediated inflammation, under certain conditions in which balance in the immune system is disrupted, is the underlying pathogenic mechanism of certain autoimmune disorders, e.g., rheumatoid arthritis, Graves’ disease, multiple sclerosis, and psoriasis. In the present study, using transcriptomic profiling, we selected genes and analyzed the expression of these genes to find potential novel markers of Th17 lymphocytes. We found that APOD (apolipoprotein D); C1QL1 (complement component 1, Q subcomponent-like protein 1); and CTSL (cathepsin L) are expressed at significantly higher mRNA and protein levels in Th17 cells than in the Th1, Th2, and Treg subtypes. Interestingly, these genes and the proteins they encode are well associated with the function of Th17 cells, as these cells produce inflammation, which is linked with atherosclerosis and angiogenesis. Furthermore, we found that high expression of these genes in Th17 cells is associated with the acetylation of H2BK12 within their promoters. Thus, our results provide new information regarding this cell type. Based on these results, we also hope to better identify pathological conditions of clinical significance caused by Th17 cells.

Reverse plasticity: TGF-β and IL-6 induce Th1-to-Th17-cell transdifferentiation in the gut

2016 ◽  
Vol 46 (10) ◽  
pp. 2306-2310 ◽  
Author(s):  
Jens Geginat ◽  
Moira Paroni ◽  
Ilko Kastirr ◽  
Paola Larghi ◽  
Massimiliano Pagani ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Cell Transdifferentiation

Author response for "Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery"

2018 ◽  
Author(s):  
Alicia S. Wilson ◽  
Hsei Di Law ◽  
Christiane B. Knobbe‐Thomsen ◽  
Conor J. Kearney ◽  
Jane Oliaro ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Mutant Mice ◽  
Author Response

Author response for "Suppression of Aiolos and Ikaros expression by lenalidomide reduces human ILC3−ILC1/NK cell transdifferentiation"

2019 ◽  
Author(s):  
Luca Mazzurana ◽  
Marianne Forkel ◽  
Anna Rao ◽  
Aline Acker ◽  
Efthymia Kokkinou ◽  
...  
Keyword(s):  
Nk Cell ◽  
Author Response ◽  
Cell Transdifferentiation
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