Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis

Introduction: Currently there is a growing interest in studying systemic conditions with impact on the periodontium. The aim of this article is to determinate if there is a relation between Hashimoto’s thyroiditis and periodontal disease.Material and Methods: Founded on periodontology based on evidence and in the combination of the keywords: ‘Hashimoto disease’; ‘Hypothyroidism’; ‘Periodontal disease’; ‘Systemic Diseases’; a search and evaluation of articles was conducted in Medline, Scopus and Thomson Reuters databases, selecting 30 articles for integral analysis.Results: There have been developed several studies, searching for a better comprehension about the complexity and pathogenesis of periodontal diseases, associated them to multiple systemic conditions. Actually, the relationship that is best described in the literature is the one with rheumatoid arthritis; however, other relations have been pointed, such as Hashimoto’s thyroiditis.Discussion: The identification of multiple etiopathogenic mechanisms common to Hashimoto’s thyroiditis and periodontal disease allow to suspect of a relation between them. Some of these mechanisms include the proliferation of lymphocytes T helper 1 and T helper 17 and their impact on the periodontium, the dysfunction of vascular endothelium in gingival microcirculation and the influence of hypothyroidism on bone metabolism, namely on the alveolar bone.Conclusion: There is biological plausibility to support the establishment of an association between Hashimoto’s thyroiditis and periodontal disease. However, there are not enough studies to support the existence of a causal nexus between these two pathologies, so, in the future, more studies should be conducted to determinate there relation and interaction.

Download Full-text

Predominant T helper 1 cells in patients with idiopathic portal hypertension

Journal of Gastroenterology and Hepatology ◽

10.1046/j.1440-1746.2000.02330.x ◽

2000 ◽

Vol 15 (11) ◽

pp. 1312-1317 ◽

Cited By ~ 1

Author(s):

Katsutoshi Tokushige ◽

Katsumi Yamauchi ◽

Tatsuji Komatsu ◽

Ken Takasaki ◽

Naoaki Hayashi

Keyword(s):

Portal Hypertension ◽

Idiopathic Portal Hypertension ◽

T Helper ◽

T Helper 1 ◽

T Helper 1 Cells

Download Full-text

Analysis of Circulating microRNA Signatures and Preeclampsia Development

Cells ◽

10.3390/cells10051003 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1003

Author(s):

Margarita L. Martinez-Fierro ◽

Idalia Garza-Veloz

Keyword(s):

Pregnant Women ◽

Expression Profiling ◽

Gene Prediction ◽

Microrna Expression ◽

Differentially Expressed ◽

Control Group ◽

Case Group ◽

Circulating Microrna ◽

Activated T Cells ◽

Serum Microrna

microRNAs are important regulators of cell processes and have been proposed as potential preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify microRNAs involved in preeclampsia development. Serum microRNA expression profiling was evaluated at 12, 16, and 20 weeks of gestation (WG), and at the time of preeclampsia diagnosis. Two groups were evaluated using TaqMan low-density array plates: a control group with 18 normotensive pregnant women and a case group with 16 patients who developed preeclampsia during the follow-up period. Fifty-three circulating microRNAs were differentially expressed between groups (p < 0.05). Compared with controls, hsa-miR-628-3p showed the highest relative quantity values (at 12 WG = 7.7 and at 20 WG = 3.45) and the hsa-miRs -151a-3p and -573 remained differentially expressed from 16 to 20 WG (p < 0.05). Signaling pathways including cancer-related, axon guidance, Neurotrophin, GnRH, VEGF, and B/T cell receptor, were most commonly altered. Further target gene prediction revealed that nuclear factor of activated T-cells 5 gene was included among the transcriptional targets of preeclampsia-modulated microRNAs. Specific microRNAs including hsa-miRs -628-3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.

Download Full-text