scholarly journals The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

2021 ◽  
Vol 12 ◽  
Author(s):  
Tom Macleod ◽  
Anna Berekmeri ◽  
Charlie Bridgewood ◽  
Martin Stacey ◽  
Dennis McGonagle ◽  
...  
Keyword(s):  
Barrier Function ◽  
Family Members ◽  
Physiological Role ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Inhibitory Pathway ◽  
Gain Of Function ◽  
Cutaneous Inflammation ◽  
Epidermal Barrier

The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37 and IL-38) in the skin. We focus on novel aspects of their interaction with commensals and pathogens, the important impact of proteases on cytokine activity, on healing responses and inflammation limiting mechanisms. We discuss IL-1 family cytokines in the context of IL-4/IL-13 and IL-23/IL-17 axis-driven diseases and highlight consequences of human loss/gain of function mutations in activating or inhibitory pathway molecules. This review highlights recent findings that emphasize the importance of IL-1 family cytokines in both physiological and pathological cutaneous inflammation and emergent translational therapeutics that are helping further elucidate these cytokines.

scholarly journals 676 Minimum role of filaggrin-gene mutations in the skin barrier function of atopic dermatitis

2018 ◽  
Vol 138 (5) ◽  
pp. S115
Author(s):  
M. Ota ◽  
T. Sasaki ◽  
T. Ebihara ◽  
S. Murata ◽  
S. Kaneko ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Gene Mutations ◽  
Skin Barrier ◽  
Skin Barrier Function

The role of skin barrier function in atopic dermatitis: an update

2012 ◽  
Vol 7 (3) ◽  
pp. 247-257 ◽  
Author(s):  
Regina Fölster-Holst ◽  
Stephan Dähnhardt-Pfeiffer ◽  
Dorothee Dähnhardt ◽  
Ehrhardt Proksch
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

scholarly journals Physiological Effects of Manganese Gluconate and Calcium Combination from Saint-Gervais Mont Blanc Spring Water for Human Keratinocytes Differentiation

2021 ◽  
Vol 7 (2) ◽  
pp. 1-6
Author(s):  
Franck Juchaux ◽  
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Human Keratinocytes ◽  
Spring Water ◽  
Keratinocyte Differentiation ◽  
Skin Barrier Function ◽  
Transglutaminase 1

Alterations of skin barrier function affect quality of life and there is a need to develop dermatological/cosmetic treatments to reinforce or restore it. Inspiring of Hailey-Hailey disease, in which barrier alteration is due to a mutation of a Calcium-transporting protein (ATP2C1), we focused on the role of minerals and more especially those contained in Saint-Gervais Mont Blanc (SGMB) spring water to reinforce barrier function. Objectives: Demonstrate the interest to enrich SGMB spring water with manganese to improve both keratinocytes differentiation and barrier function. Methods: Effects of treatments on the expression of ATP2C1 and on the expression of key markers in keratinocyte differentiation and barrier function were studied by gene expression analysis on keratinocytes monolayers and also by measuring the protein expression of transglutaminase 1 using in situ immunofluorescence and image analysis in keratinocytes monolayers. Results: SGMB spring water stimulates transcriptomic expression of key markers involved in keratinocytes differentiation and barrier function while manganese gluconate has no effect. Combination of both dramatically enhances keratinocytes differentiation, in a synergistic way, at both transcriptomic and protein level. None of treatments modulated ATP2C1 expression. Conclusion: These results highlight the interest to enrich SGMB spring water with manganese to boost keratinocytes differentiation and barrier function.

scholarly journals 322 The Role of carbonylated proteins in corneocytes on skin barrier function

2019 ◽  
Vol 139 (5) ◽  
pp. S56
Author(s):  
H. Masaki ◽  
N. Kikuchi ◽  
T. Mizutani ◽  
Y. Okano
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Skin Barrier Function

scholarly journals Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Gihyeon Kim ◽  
Misun Kim ◽  
Minji Kim ◽  
Changho Park ◽  
Youngmin Yoon ◽  
...  
Keyword(s):  
Human Skin ◽  
Barrier Function ◽  
Skin Diseases ◽  
Lipid Synthesis ◽  
Skin Barrier ◽  
Streptococcus Thermophilus ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Skin Structure

AbstractAn unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. Metagenomic analyses showed the abundance of Streptococcus in younger individuals or those having more elastic skin. Particularly, we isolated Streptococcus pneumoniae, Streptococcus infantis, and Streptococcus thermophilus from face of young individuals. Treatment with secretions of S. pneumoniae and S. infantis induced the expression of genes associated with the formation of skin structure and the skin barrier function in human skin cells. The application of culture supernatant including Streptococcal secretions on human skin showed marked improvements on skin phenotypes such as elasticity, hydration, and desquamation. Gene Ontology analysis revealed overlaps in spermidine biosynthetic and glycogen biosynthetic processes. Streptococcus-secreted spermidine contributed to the recovery of skin structure and barrier function through the upregulation of collagen and lipid synthesis in aged cells. Overall, our data suggest the role of skin microbiome into anti-aging and clinical applications.

scholarly journals Study of Skin Barrier Function in Psoriasis: The Impact of Emollients

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 651
Author(s):  
Daniel Maroto-Morales ◽  
Trinidad Montero-Vilchez ◽  
Salvador Arias-Santiago
Keyword(s):  
Barrier Function ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Psoriatic Skin ◽  
Skin Barrier Function ◽  
Epidermal Barrier ◽  
Stratum Corneum Hydration ◽  
Systemic Inflammatory Disease ◽  
Water Based ◽  
The Impact

Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m−2·h−1; p < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), p < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m−2·h−1 (p = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m−2·h−1 (p = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (p = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula.

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