scholarly journals Characterization of Lenticulostriate Arteries and Its Associations With Vascular Risk Factors in Community-Dwelling Elderly

2021 ◽  
Vol 13 ◽  
Author(s):  
Xiaopei Xu ◽  
Xiao Wu ◽  
Chengcheng Zhu ◽  
Ruiting Zhang ◽  
Yeerfan Jiaerken ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebral Artery ◽  
Vascular Risk Factors ◽  
Community Dwelling ◽  
Small Vessel ◽  
Imaging Biomarkers ◽  
Elderly Subjects ◽  
Vascular Risk ◽  
Lenticulostriate Arteries ◽  
Vessel Tortuosity

Lenticulostriate arteries (LSAs) supply blood to important subcortical areas and are, therefore, essential for maintaining the optimal functioning of the brain’s most metabolically active nuclei. Past studies have demonstrated the potential for quantifying the morphology of LSAs as biomarkers of vascular fragility or underlying arteriopathies. Thus, the current study aims to evaluate the morphological features of LSAs, their potential value in cerebrovascular risk stratification, and their concordance with other vascular risk factors in community-dwelling elderly people. A total of 125 community-dwelling elderly subjects who underwent a brain MRI scan were selected from our prospectively collected imaging database. The morphological measures of LSAs were calculated on the vascular skeletons obtained by manual tracing, and the number of LSAs was counted. Additionally, imaging biomarkers of small vessel disease were evaluated, and the diameters of major cerebral arteries were measured. The effects of vascular risk factors on LSA morphometry, as well as the relationship between LSA measures and other imaging biomarkers, were investigated. We found that smokers had shorter (p = 0.04) and straighter LSAs (p < 0.01) compared to nonsmokers, and the presence of hypertension is associated with less tortuous LSAs (p = 0.03) in community-dwelling elderly. Moreover, the middle cerebral artery diameter was positively correlated with LSA count (r = 0.278, p = 0.025) and vessel tortuosity (r = 0.257, p = 0.04). The posterior cerebral artery diameter was positively correlated with vessel tortuosity and vessel length. Considering the scarcity of noninvasive methods for measuring small artery abnormalities in the brain, the LSA morphological measures may provide valuable information to better understand cerebral small vessel degeneration during aging.

Vascular and non-vascular risk factors for deep white matter lesions in community-dwelling elderly subjects

2003 ◽  
Vol 3 (1) ◽  
pp. 36-43
Author(s):  
Hiroshi Yao ◽  
Takefumi Yuzuriha ◽  
Hiroshi Koga ◽  
Yuki Takashima ◽  
Kenji Fukuda ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
White Matter Lesions ◽  
Vascular Risk Factors ◽  
Community Dwelling ◽  
Elderly Subjects ◽  
Vascular Risk ◽  
Deep White Matter

scholarly journals A Warning Index Used in Prescreening for Alzheimer’s Disease, Based on Self-Reported Cognitive Deficits and Vascular Risk Factors for Dementia in Elderly Patients with Type 2 Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Toshioki Matsuzawa ◽  
Toshihiro Takata ◽  
Koichi Yokono ◽  
Hiroo Ueda ◽  
Kensuke Moriwaki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Normal Subjects ◽  
Routine Care ◽  
Vascular Risk Factors ◽  
Elderly Subjects ◽  
Vascular Risk ◽  
Characteristic Analysis

Background/Aims. Diabetes might increase the risk of Alzheimer’s disease (AD). For detecting dementia, it is typical to obtain informants’ perceptions of cognitive deficits, but such interviews are usually difficult in routine care. We aimed to develop a model for predicting mild to moderate AD using a self-reported questionnaire and by evaluating vascular risk factors for dementia in elderly subjects with diabetes.Methods. We recruited 286 diabetic and 155 nondiabetic elderly subjects. There were 25 patients with AD and 261 cognitively normal individuals versus 30 with AD and 125 normal subjects, respectively. Each participant answered subjective questions on memory deficits and daily functioning. Information on vascular risk factors was obtained from clinical charts, and multivariate logistic regression was used to develop a model for predicting AD.Results. The predicted probabilities used in screening for AD in diabetic subjects constituted age, education, lower diastolic blood pressure, subjective complaints of memory dysfunction noticeable by others, and impaired medication, shopping, and travel outside a familiar locality. Receiver operating characteristic analysis revealed a satisfactory discrimination for AD specific for diabetic elderly subjects, with 95.2% sensitivity and 90.6% specificity.Conclusion. This is the first useful index that can prescreen for AD in elderly subjects with diabetes.

P2-115: Influence of vascular risk factors on cognitive performance in community-dwelling African Americans

2008 ◽  
Vol 4 ◽  
pp. T405-T405
Author(s):  
Christine M. Khosropour ◽  
N. Maritza Dowling ◽  
Whitney Wharton ◽  
Dorothy F. Edwards ◽  
Cynthia M. Carlsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
African Americans ◽  
Cognitive Performance ◽  
Vascular Risk Factors ◽  
Community Dwelling ◽  
Vascular Risk

scholarly journals Association between cerebral small vessel diseases and mild parkinsonian signs in the elderly with vascular risk factors

2016 ◽  
Vol 26 ◽  
pp. 29-34 ◽  
Author(s):  
Jun Hatate ◽  
Kaori Miwa ◽  
Mari Matsumoto ◽  
Tsutomu Sasaki ◽  
Yoshiki Yagita ◽  
...  
Keyword(s):  
Risk Factors ◽  
The Elderly ◽  
Vascular Risk Factors ◽  
Small Vessel ◽  
Vascular Risk ◽  
Cerebral Small Vessel Diseases

Abstract W MP58: The Relationship Between Carotid Stiffness, Diastolic Diameter, and White Matter Hyperintensity Volume: The Northern Manhattan Study

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Matthew S Markert ◽  
Chuanhui Dong ◽  
David Della-Morte ◽  
Eugene Roberts ◽  
Susanne Bartels ◽  
...  
Keyword(s):  
Risk Factors ◽  
White Matter ◽  
Small Vessel Disease ◽  
Vascular Risk Factors ◽  
Small Vessel ◽  
White Matter Hyperintensity ◽  
Large Artery ◽  
Vascular Risk ◽  
Vessel Disease ◽  
Carotid Stiffness

Background: Changes in the extracranial vasculature may be associated with small vessel disease in the brain. We sought to examine the association of carotid stiffness and carotid diastolic diameter with white matter hyperintensity volume (WMHV), a magnetic resonance imaging (MRI) measure for cerebral small vessel disease, in a multi-ethnic community-based cohort. Methods: We evaluated 1140 stroke-free participants in the Northern Manhattan study who underwent brain MRIs and high-resolution carotid ultrasounds. We used linear regression to examine carotid stiffness and diastolic diameter with WMHV after adjusting for sociodemographics, lifestyle behaviors, and traditional vascular risk factors. Results: Among 1140 participants (mean age: 70.6±9.0 years; 61% women; 15% White, 16% Black, 59% Hispanics), the mean carotid stiffness was 8.19 ± 5.39, mean carotid diastolic diameter was 6.16 ± 0.93 mm, and mean WMHV 0.68 ± 0.84. In a fully adjusted model, diastolic diameter was associated with log-WMHV (β=0.10, p=0.001). In a stratified multivariable linear model, greater carotid arterial stiffness and diastolic diameter were associated with log-WMHV among Hispanics (β=0.15, p=0.005 and β=0.13, p<0.001, respectively), but not among blacks or whites. Conclusion: Greater carotid stiffness and diastolic diameter were associated with greater WMHV independent of demographics and traditional vascular risk factors, especially among Hispanics. Further studies are needed to understand how these large artery characteristics relate to WMH formation and lesion load. Carotid ultrasound may be a useful tool to assess the risk of increased brain white matter disease in a pre-clinical stage.

scholarly journals Similar Theory of Mind Deficits in Community Dwelling Older Adults with Vascular Risk Profile and Patients with Mild Cognitive Impairment: The Case of Paradoxical Sarcasm Comprehension

2021 ◽  
Vol 11 (5) ◽  
pp. 627
Author(s):  
Glykeria Tsentidou ◽  
Despina Moraitou ◽  
Magda Tsolaki
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Theory Of Mind ◽  
Vascular Risk Factors ◽  
Community Dwelling ◽  
Healthy Controls ◽  
Vascular Risk ◽  
Prediction And Prevention

Recent studies deal with disorders and deficits caused by vascular syndrome in efforts for prediction and prevention. Cardiovascular health declines with age due to vascular risk factors, and this leads to an increasing risk of cognitive decline. Mild cognitive impairment (MCI) is defined as the negative cognitive changes beyond what is expected in normal aging. The purpose of the study was to compare older adults with vascular risk factors (VRF), MCI patients, and healthy controls (HC) in social cognition and especially in theory of mind ability (ToM). The sample comprised a total of 109 adults, aged 50 to 85 years (M = 66.09, SD = 9.02). They were divided into three groups: (a) older adults with VRF, (b) MCI patients, and (c) healthy controls (HC). VRF and MCI did not differ significantly in age, educational level or gender as was the case with HC. Specifically, for assessing ToM, a social inference test was used, which was designed to measure sarcasm comprehension. Results showed that the performance of the VRF group and MCI patients is not differentiated, while HC performed higher compared to the other two groups. The findings may imply that the development of a vascular disorder affecting vessels of the brain is associated from its “first steps” to ToM decline, at least regarding specific aspects of it, such as paradoxical sarcasm understanding.

Sign in / Sign up

Export Citation Format

Share Document