scholarly journals Parameters of Memory Reconsolidation: Learning Mode Influences Likelihood of Memory Modification

2020 ◽  
Vol 14 ◽  
Author(s):  
Katharine C. Simon ◽  
Lynn Nadel ◽  
Rebecca L. Gómez
2021 ◽  
Vol 15 ◽  
Author(s):  
Gayoung Kim ◽  
Minjae Kwon ◽  
Wonjun Kang ◽  
Sue-Hyun Lee

Memory reconsolidation holds great hope for memory modification approaches and clinical treatments of mental disorders associated with maladaptive memories. However, it remains controversial as to whether reconsolidation is a general property of all types of memory. Especially, discrepancies have been reported in research focusing on whether declarative memory undergoes reconsolidation, and whether old memories can be reorganized after retrieval. Here, we discuss how these inconsistent results can be reconciled and what information we need to uncover for the general use of reconsolidation.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiao Lin ◽  
Jiahui Deng ◽  
Kai Yuan ◽  
Qiandong Wang ◽  
Lin Liu ◽  
...  

AbstractThe majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues. This conditioned craving is mediated by reward memories that are frequently experienced and stubbornly resistant to treatment. Reconsolidation theory posits that well-consolidated memories are destabilized after retrieval, and this process renders memories labile and vulnerable to amnestic intervention. This study tests the retrieval reconsolidation procedure to decrease nicotine craving among people who smoke. In this study, 52 male smokers received a single dose of propranolol (n = 27) or placebo (n = 25) before the reactivation of nicotine-associated memories to impair the reconsolidation process. Craving for smoking and neural activity in response to smoking-related cues served as primary outcomes. Functional magnetic resonance imaging was performed during the memory reconsolidation process. The disruption of reconsolidation by propranolol decreased craving for smoking. Reactivity of the postcentral gyrus in response to smoking-related cues also decreased in the propranolol group after the reconsolidation manipulation. Functional connectivity between the hippocampus and striatum was higher during memory reconsolidation in the propranolol group. Furthermore, the increase in coupling between the hippocampus and striatum positively correlated with the decrease in craving after the reconsolidation manipulation in the propranolol group. Propranolol administration before memory reactivation disrupted the reconsolidation of smoking-related memories in smokers by mediating brain regions that are involved in memory and reward processing. These findings demonstrate the noradrenergic regulation of memory reconsolidation in humans and suggest that adjunct propranolol administration can facilitate the treatment of nicotine dependence. The present study was pre-registered at ClinicalTrials.gov (registration no. ChiCTR1900024412).


2017 ◽  
Vol 144 ◽  
pp. 174-185 ◽  
Author(s):  
Kevin van Schie ◽  
Suzanne C. van Veen ◽  
Yanniek R. Hendriks ◽  
Marcel A. van den Hout ◽  
Iris M. Engelhard

2017 ◽  
Vol 142 ◽  
pp. 79-84 ◽  
Author(s):  
Andressa Radiske ◽  
Janine I. Rossato ◽  
Maria Carolina Gonzalez ◽  
Cristiano A. Köhler ◽  
Lia R. Bevilaqua ◽  
...  

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