scholarly journals Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?

2020 ◽  
Vol 14 ◽  
Author(s):  
Qianjie Yang ◽  
Yunxiang Zhou ◽  
Yuting Sun ◽  
Yi Luo ◽  
Ye Shen ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Targets

scholarly journals Profiling withanolide A for therapeutic targets in neurodegenerative diseases

2019 ◽  
Vol 27 (12) ◽  
pp. 2508-2520 ◽  
Author(s):  
Erika A. Crane ◽  
Wolfgang Heydenreuter ◽  
Katharina R. Beck ◽  
Petra Strajhar ◽  
Jan Vomacka ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Therapeutic Targets ◽  
Withanolide A

Using proteomics to identify ubiquitin ligase–substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases

2019 ◽  
Vol 76 (13) ◽  
pp. 2499-2510 ◽  
Author(s):  
Stephanie L. Rayner ◽  
Marco Morsch ◽  
Mark P. Molloy ◽  
Bingyang Shi ◽  
Roger Chung ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Ubiquitin Ligase ◽  
Therapeutic Targets ◽  
Novel Methods

scholarly journals Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation

2017 ◽  
Vol 2017 ◽  
pp. 1-18 ◽  
Author(s):  
Audrey Ortega-Ramírez ◽  
Rosario Vega ◽  
Enrique Soto
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Ion Channels ◽  
Neurodegenerative Diseases ◽  
Therapeutic Targets ◽  
Recent Advances ◽  
Acid Sensing Ion Channels ◽  
Inflammatory Processes

Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues. Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.

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