scholarly journals Ghrelin Enhancer, the Latest Evidence of Rikkunshito

2021 ◽  
Vol 8 ◽  
Author(s):  
Chihiro Yamada ◽  
Tomohisa Hattori ◽  
Shunsuke Ohnishi ◽  
Hiroshi Takeda
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Herbal Medicine ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
The Elderly ◽  
Gastrointestinal Diseases ◽  
Ghrelin Receptor ◽  
Japanese Herbal Medicine ◽  
Orexigenic Peptide ◽  
The Brain

Rikkunshito is a Japanese herbal medicine (Kampo) that has been attracting attention and researched by many researchers not only in Japan but also worldwide. There are 214 rikkunshito articles that can be searched on PubMed by August 2021. The reason why rikkunshito has attracted so much attention is due to an epoch-making report (Gastroenterology, 2008) discovered that rikkunshito promotes the secretion of the orexigenic peptide ghrelin. Since then, many researchers have discovered that rikkunshito has a direct effect on the ghrelin receptor, GHS-R1a, and an effect of enhancing the ghrelin signal to the brain. Additionally, a lot of evidence that rikkunshito is expected to be effective for various gastrointestinal diseases have also been demonstrated. Numerous basic and clinical studies have suggested that rikkunshito affects (i) various discomforts caused by anticancer drugs, gastroesophageal reflux disease, functional dyspepsia, (ii) various stress-induced anorexia, (iii) hypophagia in the elderly, and (iv) healthy lifespan. In this review, as one who discovered the ghrelin enhancer effect of rikkunshito, we will review the research of rikkunshito so far and report on the latest research results.

Efficacy of the Japanese herbal medicine rikkunshito in infants with gastroesophageal reflux disease

2015 ◽  
Vol 57 (4) ◽  
pp. 673-676 ◽  
Author(s):  
Kohei Otake ◽  
Keiichi Uchida ◽  
Koichiro Mori ◽  
Shozo Ide ◽  
Yuhki Koike ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Herbal Medicine ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Japanese Herbal Medicine

Determinants of Symptoms Suggestive of Gastroesophageal Reflux Disease in the Elderly

1993 ◽  
Vol 28 (11) ◽  
pp. 1011-1014 ◽  
Author(s):  
I. Räihä ◽  
O. Impivaara ◽  
M. Seppälä ◽  
L-R. Knuts ◽  
L. Sourander
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
The Elderly

scholarly journals Nutritional Deficiencies Associated with Gastroesophageal Reflux Disease (GERD) in Elderly/Older Adults

2020 ◽  
pp. 1-5
Author(s):  
Bonny Burns-Whitmore ◽  
Bonny Burns-Whitmore ◽  
Erik Froyen
Keyword(s):  
Older Adults ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Treatment Protocol ◽  
The Elderly ◽  
Acid Reflux ◽  
Nutritional Deficiencies ◽  
Nutrient Deficiencies ◽  
H2 Blockers

Introduction: Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder encountered in the elderly patient. GERD is one of the highly prevalent diseases seen in the clinical practice. In the elderly population, few studies have addressed the prevalence of GERD. It is estimated that 20-30% of the US population experience weekly symptoms of GERD, and two out of five people experience heartburn or acid regurgitation at least once a month. Methods: To ensure peer-review articles were used, the search engine, PubMed was utilized along with medical reference-related websites and US Department websites as well as professional organizations. Some medications used by older adults may promote acid reflux, prescription treatments include proton pump inhibitors (PPIs), coating agents, H2 blockers and over-the-counter medications that contain antacids or decreased dosages of the prescription strength H2 blockers and PPIs. Discussion: Decreased stomach acidity could be responsible for risk of nutrient deficiencies including vitamin B12 (cobalamin), vitamin C (ascorbate), calcium, iron and magnesium deficiencies or medications that are used to alleviate the symptoms of GERD may also be responsible for increasing the risk for deficiencies. The purpose of this review is to demonstrate and provide reasons why regular assessment, screening, testing, and/or clinically evaluating nutritional deficiencies common in older adults and relating to physical pathogenesis and/or drug treatments of GERD, should be added to the GERD treatment protocol for older adults.

Effects of herbal medicine in gastroesophageal reflux disease symptoms: a systematic review and meta-analysis

2020 ◽  
Vol 5 (6) ◽  
pp. 464–475
Author(s):  
Fariba Sadeghi ◽  
Seyed Mohammad ◽  
Bita Sepehri ◽  
Laleh Khodaie ◽  
Hassan Monirifar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Gastroesophageal Reflux Disease ◽  
Herbal Medicine ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Meta Analysis ◽  
Disease Symptoms
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