H. pylori cagA, vacA and iceA genotype associations with gastroesophageal reflux disease (GERD) compared to other upper gastrointestinal diseases

2000 ◽  
Vol 118 (4) ◽  
pp. A1266
Author(s):  
Andreas Leodolter ◽  
Kathlen Wolle ◽  
Matthias Ebert ◽  
Wolfgang Koenig ◽  
Peter Malfertheiner
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Gastrointestinal Diseases ◽  
H Pylori ◽  
Upper Gastrointestinal

scholarly journals Helicobacter pylori and Other Gastrointestinal Diseases

2020 ◽  
Vol 20 (1) ◽  
pp. 38-46
Author(s):  
Jong Kyu Park
Keyword(s):  
Helicobacter Pylori ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Bacterial Pathogen ◽  
Inverse Correlation ◽  
Gastrointestinal Diseases ◽  
Epidemiologic Studies ◽  
Persistent Symptoms ◽  
H Pylori

<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the most prevalent bacterial pathogen that infects approximately half of the world’s population. It is well known that <i>H. pylori</i> causes chronic gastritis, peptic ulcer, and gastric cancer. <i>H. pylori</i> can also be associated with other gastrointestinal diseases. Epidemiologic studies have reported an inverse correlation between <i>H. pylori</i> infection and gastroesophageal reflux disease. However, the results of <i>H. pylori</i> eradication in patients with gastroesophageal reflux disease were not consistent with epidemiologic studies. Many studies have reported symptomatic improvement in uninvestigated dyspepsia and functional dyspepsia (FD) following <i>H. pylori</i> eradication, suggesting that <i>H. pylori</i> is the cause of dyspepsia. Therefore, it has been suggested that <i>H. pylori</i>-associated dyspepsia should be considered an entity distinct from FD and only the patients with persistent symptoms following eradication should be considered as having FD. A majority of studies also support an association of <i>H. pylori</i> with colon neoplasms and an inverse correlation with inflammatory bowel disease. However, no association of <i>H. pylori</i> with irritable bowel syndrome has been reported.

scholarly journals Helicobacter pyloriInfection in Gastroesophageal Reflux Disease in the Asian Countries

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Su Jin Hong ◽  
Sang Woo Kim
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Genetic Factors ◽  
De Novo ◽  
Eradication Therapy ◽  
Gastrointestinal Diseases ◽  
Esophageal Disease ◽  
Asian Countries ◽  
H Pylori

Helicobacter pyloriinfection, a common infection in many countries, is related to the clinical course of upper gastrointestinal diseases. Gastroesophageal reflux disease (GERD) is a common esophageal disease in Western countries and its prevalence is increasing in Asian countries. The pathophysiology of GERD is multifactorial. Although no single factor has been isolated as the cause of GERD, a negative association between the prevalence ofH. pyloriand the severity of GERD, including Barrett’s esophagus, has been demonstrated in epidemiological studies. The high prevalence ofH. pyloriinfection affects the incidence of GERD in Asian countries. In the subjects with East Asian CagA-positive strains, acid injury may be minimized by hypochlorhydria from pangastritis and gastric atrophy. Additionally, host genetic factors may affect the development of GERD. The interactions between genetic factors and the virulence ofH. pyloriinfection may be the reason for the low prevalence of GERD in Asian countries.H. pylorieradication is not considered pivotal in GERD exacerbation based on evidence from Western studies. A recent meta-analysis demonstrated that eradication therapy ofH. pyloriwas related to a higher risk of developingde novoGERD in Asian studies.H. pyloriinfection remains an inconclusive and important issue in GERD in Asian countries.

scholarly journals GASTROESOPHAGEAL REFLUX DISEASE

2011 ◽  
Vol 18 (04) ◽  
pp. 693-696
Author(s):  
ABDUL RAZZAQ WARRAICH ◽  
DR. RAFFAD ◽  
CHAUDHRY MUHAMMAD SIDDIQ ◽  
Zaheer Iqbal ◽  
Mohammad Saeed Khokhar
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Rapid Urease Test ◽  
Common Symptom ◽  
Infection Frequency ◽  
Urease Test ◽  
H Pylori ◽  
Disease Study ◽  
Study Setting

Objective: To find the frequency of H pylori infection among the patients of gastroesophgeal reflex disease. Study design: Descriptive study. Setting: Department of Medicine, Unit-I, Services Hospital, Lahore. Subject & method: One hundred patients with gastroesophageal reflux disease (GERD) were included in this study. For detection and confirmation of helicobacter pylori, endoscopy with antral biopsy was done. Specimens were sent for histopathology, and rapid urease test was performed. Main outcome measures: Frequency of H pylori infection, frequency of regurgitation, dysphagia, nausea, vomiting and haemetemesis. Results: 100 patients who fulfilled the inclusion criteria were taken. There were 65 males and 35 females respectively. Their age ranged from 18 to 48 years. 39 (39%) patients were between 29-38 years while 23 (23%) were of 39-48 years. There were 38 (38%) patients between 18-28 years. The mean age of the patients was 31.79±7.56. 40 (40%) were found to be H. pylori positive on biopsy and rapid urease test, while 60 (60%) were H. pylori negative. The most common recorded symptom was chest pain/retrosternal burning (90%). Regurgitation (65%) and nausea (55%) were other common symptoms. Dysphagia and water-brash were present in 40% each. Vomiting (30%), abdominal pain (25%) and cough (20%) were the other symptoms. The least common symptom was haemetemesis (5%). Conclusions: A causal relationship between GERD and H. pylori infection could not be established. Therefore, routine H. pylori eradication in the treatment of patients with GERD is not recommended. 

scholarly journals Helicobacter pylori infection reduces the risk of gastroesophageal reflux disease

2021 ◽  
pp. 96-101
Author(s):  
R. I. Khlynova ◽  
O. M. Khromtsova ◽  
R. B. Berdnikov ◽  
I. B. Khlynov
Keyword(s):  
Helicobacter Pylori ◽  
Gastroesophageal Reflux Disease ◽  
Gastric Mucosa ◽  
Gastroesophageal Reflux ◽  
Observational Study ◽  
Reflux Disease ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Biopsy Specimens ◽  
H Pylori

The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.

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