scholarly journals Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State

2020 ◽  
Vol 8 ◽  
Author(s):  
Michael B. Anthracopoulos ◽  
Mark L. Everard
Keyword(s):  
Smooth Muscle ◽  
Homeostatic Control ◽  
Airways Smooth Muscle

G-Proteins in Airways Smooth Muscle

1994 ◽  
pp. 187-213
Author(s):  
Nigel J. Pyne ◽  
Susan Pyne
Keyword(s):  
Smooth Muscle ◽  
G Proteins ◽  
Airways Smooth Muscle

Interaction between chloroquine and indomethacin in airways smooth muscle in vivo

1987 ◽  
Vol 137 (1) ◽  
pp. 135-138 ◽  
Author(s):  
Arthur C. Sackeyfio ◽  
Daniel K. Amankwaah ◽  
Alhassan S. Yahaya
Keyword(s):  
Smooth Muscle ◽  
Airways Smooth Muscle

scholarly journals Epithelium-dependent regulation of airways smooth muscle function. A histamine-nitric oxide pathway

1998 ◽  
Vol 7 (6) ◽  
pp. 409-411 ◽  
Author(s):  
Konstantinos Gourgoulianis ◽  
Zoe Iliodromitis ◽  
Apostolia Hatziefthimiou ◽  
Paschalis-Adam Molyvdas
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Airway Epithelium ◽  
Muscle Function ◽  
Smooth Muscles ◽  
Airways Smooth Muscle ◽  
Smooth Muscle Function ◽  
No Release ◽  
Nos Inhibitor

The airway epithelium is responsible for the production of a number of arachidonic acid and nonprostanoid inhibitory factors. Epithelium synthesises nitric oxide (NO) which may be important in regulating the function of airways smooth muscles. We studiedin vitrothe effect of histamine (100 nM100 μ M) which increases the NO release on rabbit airway smooth muscles induced by 80 mM KCl in the presence or not of 10-5Methylene blue (MB) (inactivator of guanylate cyclase) or N(G)-monomethyl L-arginine (L-NMMA), a NOS inhibitor. All experiments were done in tracheal muscle strips from 28 rabbits with epithelium and after epithelium removal. The additional use of histamine (1 μ M) on KCl contraction induced a relaxation of 10% of the initial contraction. The additional use of L-NMMA decreased the relaxation to 5% of initial contraction. MB rather than L-NMMA increased the contraction significantly(p<0.01). Epithelium removal increased the contraction induced by KCl (80 mM) and histamine (1 μ M) by about 30%(p<0.001). NO release especially from epithelium regulates the airways smooth muscle functions. Damage to the epithelium may contribute to an increase in airways sensitivity, observed in asthma.

Airways smooth muscle

1987 ◽  
Vol 80 (3) ◽  
pp. 409-411 ◽  
Author(s):  
John B. Richardson
Keyword(s):  
Smooth Muscle ◽  
Airways Smooth Muscle

Regulation of airways smooth muscle contraction through RG-1 in asthma: a proteomic approach

2020 ◽  
Author(s):  
Marisol Alvarez-Gonzalez ◽  
Mayra Alvarez-Santos ◽  
Blanca Margarita Bazan-Perkins
Keyword(s):  
Smooth Muscle ◽  
Muscle Contraction ◽  
Smooth Muscle Contraction ◽  
Proteomic Approach ◽  
Airways Smooth Muscle
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