Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis

Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is regulated and incorporated into the chromatin in a replication-independent manner through HIRA and DAXX/ATRX. Current literature suggests that dysregulated expression of histone chaperones may be implicated in tumor progression. Notably, ectopic expression of CAF-1 can promote a switch between canonical H3.1 and H3 variants in the chromatin, impair the chromatic state, lead to chromosome instability, and impact gene transcription, potentially contributing to carcinogenesis. This review focuses on the chaperone proteins of H3.1 and H3.3, including structure, regulation, as well as their oncogenic and tumor suppressive functions in tumorigenesis.

Electronic Structure Regulation on the Ultra-thin MOF-derived NiSe2/NiS2@NC Heterojunction for Promoting the Hydrogen Evolution Reaction

Transition metal selenides (TMSes) is considered a promising electrocatalyst for hydrogen evolution reaction (HER) due to narrow bandgap, unique morphology and low cost. Herein, using Ni-MOF as precursor, NiSe2/NiS2@NC electrocatalyst...

Electronic structure regulation of cobalt oxide clusters for promoting photocatalytic hydrogen evolution

Photocatalysis for water decomposition under solar light is a promising route to produce clean hydrogen energy. Although both single atom catalysts (SACs) and atomic cluster catalysts are effective ways to...