Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

Evaluation of an integrated in vitro–in silico PBPK (physiologically based pharmacokinetic) model to provide estimates of human bioavailability

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2005.11.002 ◽

2006 ◽

Vol 308 (1-2) ◽

pp. 133-139 ◽

Cited By ~ 16

Author(s):

Hongliang Cai ◽

Chad Stoner ◽

Anita Reddy ◽

Sascha Freiwald ◽

Danielle Smith ◽

...

Keyword(s):

In Silico ◽

Pharmacokinetic Model ◽

The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.04.002 ◽

2020 ◽

Vol 109 (7) ◽

pp. 2345-2355

Author(s):

Kei Mayumi ◽

Miho Tachibana ◽

Mei Yoshida ◽

Shuichi Ohnishi ◽

Takushi Kanazu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

The Novel ◽

In Vitro Method ◽

Pharmacokinetic Profiles ◽

Physiologically Based ◽

High Predictability ◽

Plasma Partition Coefficient

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Cited By ~ 15

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0631-z ◽

2018 ◽

Vol 57 (10) ◽

pp. 1307-1323 ◽

Cited By ~ 4

Author(s):

Ling Song ◽

Yi Zhang ◽

Ji Jiang ◽

Shuang Ren ◽

Li Chen ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Allometric Scaling ◽

Steady State Concentration ◽

Glucokinase Activator ◽

Physiologically Based ◽

State Concentration

Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Pharmaceutical Research ◽

10.1007/s11095-017-2305-1 ◽

2018 ◽

Vol 35 (4) ◽

Author(s):

Daniel S. Hsieh ◽

Liang Luo ◽

Yan Xu ◽

Joshua D. Engstrom ◽

Qi Gao

Keyword(s):

Kinetic Model ◽

Vinyl Acetate ◽

Pharmacokinetic Model ◽

Polyvinyl Pyrrolidone ◽

Abstract 4629: Physiologically based pharmacokinetic model and correlative in vitro assessment of metabolism-based interaction between Everolimus and PI3K/mTOR inhibitor BEZ235

10.1158/1538-7445.am2014-4629 ◽

2014 ◽

Author(s):

Ganesh P. Moorthy ◽

Bilal Abuasal ◽

Larry Sallans ◽

John C. Morris ◽

George Thomas ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Mtor Inhibitor ◽

Physiologically Based ◽

In Vitro Assessment

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.0c00043 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2329-2344 ◽

Cited By ~ 4

Author(s):

Sumit Arora ◽

Amita Pansari ◽

Peter Kilford ◽

Masoud Jamei ◽

Iain Gardner ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Fed State ◽

Physiologically Based ◽

In Vivo Extrapolation

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12461 ◽

2019 ◽

Vol 8 (10) ◽

pp. 738-747 ◽

Cited By ~ 4

Author(s):

Hannah M. Jones ◽

Zhiwei Zhang ◽

Paul Jasper ◽

Haobin Luo ◽

Lindsay B. Avery ◽

...

Keyword(s):

Monoclonal Antibody ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Antibody Pharmacokinetics ◽

Vitro Data ◽

In Vitro Data

Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk

Pharmaceutical Research ◽

10.1007/s11095-014-1333-3 ◽

2014 ◽

Vol 31 (9) ◽

pp. 2367-2382 ◽

Cited By ~ 25

Author(s):

Michael Gertz ◽

Nikolaos Tsamandouras ◽

Carolina Säll ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Drug Interaction ◽

Pharmacokinetic Model ◽

Physiologically Based ◽

Drug Drug Interaction ◽

Vitro Data ◽

In Vitro Data