scholarly journals Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man

2020 ◽  
Vol 11 ◽  
Author(s):  
Bo Hjorth Bentzen ◽  
Sofia Hammami Bomholtz ◽  
Rafel Simó-Vicens ◽  
Lasse Folkersen ◽  
Lea Abildgaard ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Mechanisms Of Action ◽  
Negative Modulator

scholarly journals Novel Pharmacological Interventions to Maintain Sinus Rhythm after DC Cardioversion

2011 ◽  
Vol 2011 ◽  
pp. 1-7
Author(s):  
D. E. Thomas ◽  
Z. Yousef ◽  
R. A. Anderson
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Direct Current ◽  
Mechanisms Of Action ◽  
Novel Therapies ◽  
Pharmacological Interventions ◽  
Recurrence Rates ◽  
Direct Current Cardioversion ◽  
Dc Cardioversion ◽  
Maintain Sinus Rhythm

Despite the availability of potentially curative interventions for atrial fibrillation, there remains an important role for conventional anti-arrhythmic therapy and anti-coagulation combined with direct current cardioversion. Unfortunately, the latter approach is disturbed by high recurrence rates of atrial fibrillation. In recent years, several adjunctive therapies have emerged which may facilitate the maintenance of sinus rhythm. These novel therapies and their potential mechanisms of action are reviewed in this article.

scholarly journals Integrated Approach to Treatment-Resistant Atrial Fibrillation: Additional Value of Acupuncture

2013 ◽  
Vol 31 (3) ◽  
pp. 327-330 ◽  
Author(s):  
F A M Jonkman ◽  
M L Jonkman-Buidin
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Success Rate ◽  
Acupuncture Treatment ◽  
Integrated Approach ◽  
Mechanisms Of Action ◽  
Electrical Cardioversion ◽  
Treatment Resistant ◽  
Additional Value ◽  
Spontaneous Conversion

A 62-year-old patient with chronic bronchitis had treatment-resistant atrial fibrillation. Electrical cardioversion was performed, but sinus rhythm (SR) lasted only for some minutes. Administration of amiodarone was withheld in favour of a course of acupuncture treatment in order to increase the success rate of a second attempt of electrical cardioversion. After two acupuncture treatments, spontaneous conversion to SR occurred. Relapses into atrial fibrillation in the following five winters, associated with attacks of bronchitis, also responded to acupuncture. The mechanisms of action of the acupuncture treatment and the value of this integrated approach to treatment are discussed.

scholarly journals Flecainide is a safe and effective treatment for pre-excited atrial fibrillation rapidly conducted to the ventricle in pregnant women: a case series

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Samuel Chauveau ◽  
Olivier Le Vavasseur ◽  
Elodie Morel ◽  
Arnaud Dulac ◽  
Philippe Chevalier
Keyword(s):  
Atrial Fibrillation ◽  
Pregnant Women ◽  
Accessory Pathway ◽  
Case Series ◽  
Mechanisms Of Action ◽  
Efficacy And Safety ◽  
Case Summary ◽  
Autonomic Changes ◽  
Treatment Mechanisms ◽  
Wolff Parkinson White Syndrome

Abstract Background Pregnancy is associated with an increased incidence of cardiac arrhythmias likely due to hormonal, haemodynamic, and autonomic changes. Yet, there is little data available regarding the efficacy and safety of anti-arrhythmic agents to prevent pre-excited atrial fibrillation (AF) in pregnant women. Case summary We report on three pregnant women who developed AF rapidly conducted to the ventricle through an overt accessory pathway as the first manifestation of Wolff–Parkinson–White syndrome. Discussion All patients were treated with flecainide with neither arrhythmias recurrence nor adverse events of the treatment. Mechanisms of action and clinical efficacy of flecainide are discussed.

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