scholarly journals Cognitive Rehabilitation for Neurocognitive Late Effects in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Feasibility and Case-Series Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaja Solland Egset ◽  
Siri Weider ◽  
Jan Stubberud ◽  
Odin Hjemdal ◽  
Ellen Ruud ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Late Effects ◽  
Cognitive Rehabilitation ◽  
Lymphoblastic Leukemia ◽  
Real Life ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Program Goal ◽  
Case Series Study ◽  
Self Reports ◽  
Neurocognitive Late Effects

Neurocognitive late effects following the diagnosis and treatment of childhood acute lymphoblastic leukemia (ALL) commonly include impaired executive functions (EFs), with negative consequences for one’s health-related quality of life and mental health. However, interventions for EF impairments are scarce. Thus, the aims of this study were to (1) explore the feasibility and acceptability of the cognitive rehabilitation program Goal Management Training (GMT) and (2) examine whether GMT is associated with positive outcomes across cases of ALL survivors with EF complaints. Four participants (median age 31.5 years) underwent nine GMT modules in a total of five group sessions. Rehabilitation was focused on compensatory strategies to improve real-life EFs. Participants were evaluated at 2-week and 6-month follow-ups. Evaluation of feasibility and acceptability included adherence, a semi structured interview, self-reports, and safety. Additionally, therapists’ experience with implementation was evaluated. Outcome measures included self-reports and neurocognitive tests of attention, EF, and processing speed. All participants completed GMT and rated the intervention as useful, suitable, and satisfactory. The reliable change index showed improved daily life EFs (two participants) and neurocognitive performance (three participants) at 6-month follow-up. Additionally, all participants improved on a “real-life” task involving EF. A future randomized controlled trial is recommended.

Late effects in survivors of childhood acute lymphoblastic leukemia: a study from Thai Pediatric Oncology Group

2010 ◽  
Vol 91 (5) ◽  
pp. 850-854 ◽  
Author(s):  
Samart Pakakasama ◽  
Gavivann Veerakul ◽  
Darin Sosothikul ◽  
Su-on Chainansamit ◽  
Vichai Laosombat ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Oncology ◽  
Late Effects ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Oncology Group ◽  
Pediatric Oncology Group

scholarly journals Endocrinological and Cardiological Late Effects Among Survivors of Childhood Acute Lymphoblastic Leukemia

2013 ◽  
Vol 30 (3) ◽  
pp. 290-299 ◽  
Author(s):  
Hale Ören ◽  
Şebnem Yılmaz ◽  
Özlem Tüfekçi ◽  
Mustafa Kır ◽  
Ece Böber ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Late Effects ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals Late effects in survivors of childhood acute lymphoblastic leukemia in the context of selected gene polymorphisms

2018 ◽  
Vol 44 (1) ◽  
Author(s):  
Kinga Kwiecinska ◽  
Wojciech Strojny ◽  
Danuta Pietrys ◽  
Miroslaw Bik-Multanowski ◽  
Maciej Siedlar ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Late Effects ◽  
Gene Polymorphisms ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
María Sol Brassesco ◽  
Danilo Jordão Xavier ◽  
Marjori Leiva Camparoto ◽  
Ana Paula Montaldi ◽  
Paulo Roberto D'Auria Vieira de Godoy ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Late Effects ◽  
Lymphoblastic Leukemia ◽  
Chromosome Rearrangements ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Peripheral Lymphocytes ◽  
Life Threatening ◽  
Therapy Completion ◽  
Cure Rates

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.

Long-Term Sequelae and Late Effects In Childhood Acute Lymphoblastic Leukemia (ALL) Survivors: A Single AIEOP Center Experience

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1720-1720 ◽  
Author(s):  
Rosanna Parasole ◽  
Fara Petruzziello ◽  
Antonia De Matteo ◽  
Argia Mangione ◽  
Gaia Sepe ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Late Effects ◽  
Conflicts Of Interest ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Late Effect ◽  
Cranial Radiotherapy ◽  
Childhood All

Abstract The advent of more intensive chemotherapy and the improvement of supportive cares have dramatically changed the natural history of childhood acute lymphoblastic leukemia (ALL), with current estimated 5-year overall survival of about 80%. The increased survival rate and the establishment of follow-up survey for long term survivors (LTS) have allowed the identification of late chemo-radiotherapy adverse effects on psychological and general health. We retrospectively evaluate the incidence and type of sequelae and / or late effects in a cohort of 301 childhood ALL LTS, followed in a single pediatric AIEOP center. From June 1986 to June 2013, 301 LTS (154 male and 147 female), aged <18 years at ALL diagnosis, were followed-up by a multidisciplinary team. The surveillance protocol is summarized in Figure 1. The timing of follow-up (FU) was modified, case by case, in relation to the appearance of adverse events or organ diseases. Survivors' results were compared with chronic medical and psychological conditions of siblings (n=89). Mean FU time (time from the stop therapy to the last control) was 6 years (range 1.8-26.8 years). The majority of LTS were teenager or young adults : 35% ranged between 15 and 20 years; 19.7% was more than 21 years old and the 45.3% was less than 14 years old. During FU, 16 late recurrences (5.3%) were identified and 3 secondary malignancies (0.99%) such as one mesenteric paraganglioma and two Acute Myeloid Leukemia in second complete remission ALL LTS. 40 patients (13.3%) received cranial radiotherapy during treatment. 39 LTS (13%) reported at least one sequelae. The most frequent sequelae were neurological and orthopedic (6% and 3% respectively) as summarized in Figure 2 151 LTS (50.17%) presented at least one late effect as showed in Figure 3. In our experience at least one late effect occurred in 50.17% of LTS; these late complications affect negatively the quality of life of survivors. Endocrine-metabolic events are the most frequent late effect (34,5%). 13% of LTS have at least one sequelae mainly neurological and orthopedic. Prevention and/or early identification of complications during follow-up survey of LTS are crucial in order to decrease the long-term health risks associated with curative treatment for childhood ALL. Disclosures: No relevant conflicts of interest to declare.

Genetic characterization of high hyperdiploidy in childhood acute lymphoblastic leukemia

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
R Vagkopoulou ◽  
C Eckert ◽  
U Ungethüm ◽  
G Körner ◽  
M Stanulla ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genetic Characterization ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia
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