scholarly journals Case Report: Cytoreductive Surgery and HIPEC Associated With Liver Electrochemotherapy in a Cholangiocarcinoma Patient With Peritoneal Carcinomatosis and Liver Metastasis Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Mauro Stefano ◽  
Enrico Prosperi ◽  
Paola Fugazzola ◽  
Beatrice Benini ◽  
Marcello Bisulli ◽  
...  
Keyword(s):  
Case Report ◽  
Cytoreductive Surgery ◽  
Good Condition ◽  
Length Of Hospital Stay ◽  
Intrahepatic Metastasis ◽  
Curative Therapy ◽  
Novel Treatments ◽  
Small Series ◽  
Crs And Hipec ◽  
Worse Prognosis

Introduction: Cholangiocarcinoma (CCA) is the second most common primary tumor of the liver, and the recurrence after hepatic resection (HR), the only curative therapy, is linked with a worse prognosis. Systemic chemotherapy (SC) and liver loco-regional treatments, like trans-arterial chemoembolization (TACE) or radio embolization (TARE), have been employed for the treatment of unresectable intrahepatic metastasis (IM) with benefit on overall survival (OS), but SC has a limited effect on peritoneal metastasis (PM). In the last years, novel treatments like electrochemotherapy (ECT) with bleomycine (BLM) for IM and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS and HIPEC) for PM have been applied in small series but with encouraging results. We hereby describe the first synchronous application of ECT and CRS and HIPEC for the treatment of a patient with IM and PM from CCA.Case Description: A 47-year-old male patient with CCA underwent HR followed by adjuvant SC. After 14 months, for the occurrence of IM, the patient underwent a second HR and SC. Nonetheless, a new recurrence occurred and a third attempt of HR was proposed. Due to the intraoperative finding of unresectable IM with PM, no resective procedure was performed and the patient was referred to our center. CRS and HIPEC with cisplatin and mitomycin for PM and ECT with BLM on a bulky metastasis of the hepatic hilum were performed after 38 months from the first HR. The length of hospital stay was 19 days. At the computed tomography (CT) performed 11 days after treatment complete necrosis of the treated IM was detected.Results: CT scan after 3 and 6 months and magnetic resonance after 9 months were performed. Necrosis of the treated IM nor PM but progression of the residual liver lesions was observed. After 3 months, the patient received SC and underwent TACE after 8 months and TARE after 9 months for the residual liver metastases. At 14 months from CRS and HIPEC, the patient is alive, in good condition, and with stability of the disease.Conclusions: The association of ECT and CRS and HIPEC could be safe and effective for the treatment of unresectable recurrent intrahepatic CCA with PM.

scholarly journals Multicystic peritoneal mesothelioma treated with complete cytoreductive surgery, peritonectomy and hyperthermic intra-peritoneal chemotherapy—A case report

2020 ◽  
Vol 74 ◽  
pp. 152-157
Author(s):  
Naveen Padmanabhan ◽  
Haruaki Ishibashi ◽  
Kazurou Nishihara ◽  
Shouzou Sako ◽  
Kanji Katayama ◽  
...  
Keyword(s):  
Case Report ◽  
Cytoreductive Surgery ◽  
Peritoneal Mesothelioma

scholarly journals A Case report on non-invasive ventilation in the management of acute COPD exacerbation (AECOPD)

KYAMC Journal ◽  
2013 ◽  
Vol 2 (1) ◽  
pp. 152-155
Author(s):  
Mohammed Yousuf ◽  
Khan Assaduzzaman ◽  
Mohammad Saiful Islam ◽  
SM Niaz Mowla
Keyword(s):  
Case Report ◽  
Vital Signs ◽  
Length Of Hospital Stay ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Risk Of Death ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Stay Time ◽  
Patient Stay

Recent years have seen the emergence of noninvasive ventilation (NIV) as an important tool for management of patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Several well-conducted studies in the recent years have established its role in the initial, as well as later management of these patients. The aim of this case report is to encourage ICU physician to use NIV on selected AECOPD patients, therefore to reduce the need for endotracheal intubation, the length of hospital stay, and the risk of death. In this case report, we selected a case of AECOPD whose symptoms were getting worse in spite of adequate conventional treatment. He was given NIV for 20 hours following a standard protocol. Final result showed significant improvement in patient's symptoms, vital signs and ABG parameters ultimately patient stay time in ICU was reduced and patient was also benefited financially. From this first ever-successful application of NIV in our ICU we learned that we can use it successfully in next cases.DOI: http://dx.doi.org/10.3329/kyamcj.v2i1.13522 KYAMC Journal Vol.2(1) 2011 pp.152-155

scholarly journals Gastroblastoma in Adulthood—A Rarity among Rare Cancers—A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Giovanni Centonze ◽  
Alessandro Mangogna ◽  
Tiziana Salviato ◽  
Beatrice Belmonte ◽  
Laura Cattaneo ◽  
...  
Keyword(s):  
Young Adults ◽  
Differential Diagnosis ◽  
Case Report ◽  
Clinical Approach ◽  
Review Of The Literature ◽  
Adult Age ◽  
Rare Cancers ◽  
Mesenchymal Neoplasm ◽  
Worse Prognosis

Gastroblastoma (GB) is a rare gastric epithelial-mesenchymal neoplasm, first described by Miettinen et al. So far, all reported cases described the tumor in children or young adults, and similarities with other childhood blastomas have been postulated. We report a case of GB in a 43-year-old patient with long follow up and no recurrence up to 100 months after surgery. So far, this is the second case of GB occurring in the adult age >40-year-old. Hence, GB should be considered in the differential diagnosis of microscopically comparable conditions in adults carrying a worse prognosis and different clinical approach.

scholarly journals Postoperative paralytic ileus after cytoreductive surgery combined with heated intraperitoneal chemotherapy

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Jesper Nors ◽  
Jonas Amstrup Funder ◽  
David Richard Swain ◽  
Victor Jilbert Verwaal ◽  
Tom Cecil ◽  
...  
Keyword(s):  
Median Time ◽  
Intraperitoneal Chemotherapy ◽  
Cytoreductive Surgery ◽  
Paralytic Ileus ◽  
University Hospital ◽  
Nasojejunal Tube ◽  
Heated Intraperitoneal Chemotherapy ◽  
Duration Of Surgery ◽  
Crs And Hipec ◽  
Peritoneal Malignancy

AbstractBackgroundPatients with peritoneal malignancy treated by cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) are prone to develop postoperative paralytic ileus (POI). POI is associated with significant increase in both morbidity and mortality. CRS and HIPEC commonly result in prolonged POI (PPOI). The objective was to clarify the extent of PPOI in patients treated by CRS and HIPEC for peritoneal malignancy.MethodsThis was a prospective multicenter study including patients operated with CRS and HIPEC at the Department of Surgery, Aarhus University Hospital, Denmark and the Peritoneal Malignancy Institute, Basingstoke, United Kingdom. A total of 85 patients were included over 5 months. Patients prospectively reported parameters of postoperative gastrointestinal function in a diary from post-operative day 1 (POD1) until discharge. PPOI was defined as first defecation on POD6 or later.ResultsMedian time to first flatus passage was 4 days (range 1–12). Median time to first defecation was 6 days (1–14). Median time to removal of nasojejunal tube was 4 days (3–13) and 7 days (1–43) for nasogastric tube. Forty-six patients (54%) developed PPOI. Patients with PPOI had longer time to first flatus (p<0.0001) and longer time to removal of nasojejunal tube (p=0.001). Duration of surgery correlated to time to first flatus (p=0.015) and time to removal of nasogastric or nasojejunal tube (p<0.0001) but not to time to first defecation (p=0.321).ConclusionsPostoperative gastrointestinal paralysis remains a common and serious problem in patients treated with CRS and HIPEC.

scholarly journals Superior Sagittal Sinus Invasion by Malignant Glioma: Case Report and Literature Review

2019 ◽  
Vol 38 (01) ◽  
pp. 047-050
Author(s):  
Gonçalo Figueiredo ◽  
Sérgio Moreira ◽  
Célia Pinheiro ◽  
Alfredo Calheiros
Keyword(s):  
Case Report ◽  
Tumor Recurrence ◽  
Superior Sagittal Sinus ◽  
Present Case Report ◽  
Sagittal Sinus ◽  
Histological Characteristics ◽  
Worse Prognosis ◽  
Stupp Protocol ◽  
Glioma Case ◽  
Parietal Lesion

AbstractAnaplastic oligodendrogliomas (AOs) correspond to ∼ 23% of all oligodendrogliomas. They correspond to a tumor with malignant histological characteristics, focal or diffuse, associated with a worse prognosis. In the present case report, we describe the case of a 30-year-old female submitted to resection of a right parietal lesion whose histology showed to be an AO. She underwent complementary treatment with chemotherapy and radiotherapy according to the Roger Stupp protocol. Four years after the initial diagnosis, there was tumor recurrence within the superior sagittal sinus, with no evidence of recurrence elsewhere. In the literature, we have found no similar published case reinforcing the rarity of this condition

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