Benefits of Parent Training in the Rehabilitation of Deaf or Hard of Hearing Children of Hearing Parents: A Systematic Review

The present study is a systematic review on the effectiveness of Parent Training (PT) and coaching in deaf and hard of hearing (DHH) rehabilitation programs which reviews and synthesizes the existing body of evidence to assess the benefits of these programs in enhancing parents’ sensitivity, responsivity and promoting language development in DHH children during the first years after HA fitting or CI activation. Five published studies met the Population, Intervention, Comparison and Outcomes (PICO) inclusion criteria and were eligible to be included, but heterogeneity in terms of the study design, interventions and outcomes did not allow for performing a meta-analysis. All included studies shared the view that a parent’s learning is a circular (rather than frontal) process, and the results appear promising in terms of enhancing parents’ responsiveness and promoting DHH child language development. Nevertheless, the available evidence was judged to not be robust enough due to limitations in the studies’ designs. Further high-quality evidence is needed to evaluate the true degree of clinical value and the cost effectiveness of PT programs aimed at increasing parents’ responsiveness to their DHH children.

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Foundations of Language Development in Deaf and Hard-of-Hearing Infants

The Oxford Handbook of Deaf Studies in Learning and Cognition ◽

10.1093/oxfordhb/9780190054045.013.31 ◽

2020 ◽

pp. 19-32

Author(s):

Dani Levine ◽

Daniela Avelar ◽

Roberta Michnick Golinkoff ◽

Kathy Hirsh-Pasek ◽

Derek M. Houston

Keyword(s):

Language Development ◽

Language Learning ◽

Cochlear Implants ◽

Hearing Aids ◽

Hard Of Hearing ◽

Social Processes ◽

Effective Interventions ◽

Hearing Devices ◽

Language Input ◽

Hearing Children

Copious evidence indicates that, even in the first year of life, children’s language development is beginning and is impacted by a wide array of cognitive and social processes. The extent to which these processes are dependent on early language input is a critical concern for most deaf and hard-of-hearing (DHH) children, who, unlike hearing children, are usually not immersed in a language-rich environment until effective interventions, such as hearing aids or cochlear implants, are implemented. Importantly, some cognitive and social processes are not dependent on the early availability of language input and begin to develop before children are fitted for hearing aids or cochlear implants. Interventions involving parent training may be helpful for enhancing social underpinnings of language and for maximizing DHH children’s language learning once effective hearing devices are in place. Similarly, cognitive training for DHH children may also provide benefit to bolster language development.

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The cost of chemotherapy administration: a systematic review and meta-analysis

The European Journal of Health Economics ◽

10.1007/s10198-021-01278-0 ◽

2021 ◽

Author(s):

Gursharan K. Sohi ◽

Jordan Levy ◽

Victoria Delibasic ◽

Laura E. Davis ◽

Alyson L. Mahar ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Chemotherapy Administration ◽

The Cost

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Diagnostic and prognostic value of miRNAs in hepatoblastoma: A systematic review with meta-analysis

10.37766/inplasy2021.11.0045 ◽

2021 ◽

Author(s):

Bin Wu ◽

◽

Lixia Guo ◽

Kaikai Zhen ◽

Chao Sun

Keyword(s):

Systematic Review ◽

Prognostic Value ◽

Meta Analysis ◽

Area Under The Curve ◽

Prognostic Indicator ◽

Diagnostic Odds Ratio ◽

Diagnostic Value ◽

Likelihood Ratios ◽

Clinical Value ◽

Diagnostic And Prognostic Value

Review question / Objective: Background and aim: Increasing evidence has revealed the valuable diagnostic and prognostic applications of dysregulated microRNAs (miRNAs) in hepatoblastoma (HB), the most common hepatic malignancy during childhood. However, these results are inconsistent and remain to be elucidated. In the present study, we aimed to systematically compile up-to-date information regarding the clinical value of miRNAs in HB. Methods: Articles concerning the diagnostic and prognostic value of single miRNAs for HB were searched from databases. The sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and hazard ratios (HRs) were separately pooled to explore the diagnostic and prognostic performance of miRNA. Subgroup and meta-regression analyses were further carried out only in the event of heterogeneity. Results: In all, 20 studies, involving 264 HB patients and 206 healthy individuals, met the inclusion criteria in the six included literature articles. For the diagnostic analysis of miRNAs in HB, the pooled SEN and SPE were 0.76 (95% CI: 0.72–0.80) and 0.75 (95% CI: 0.70–0.80), respectively. Moreover, the pooled PLR was 2.79 (95% CI: 2.12–3.66), NLR was 0.34 (95% CI: 0.26–0.45), DOR was 10.24 (95% CI: 6.55–16.00), and AUC was 0.83, indicating that miRNAs had moderate diagnostic value in HB. For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. The pooled HR was 1.74 (95% CI: 1.20–2.29) for overall survival (OS) and 1.74 (95% CI: 1.31–2.18) for event-free survival (EFS), suggesting its potential as a prognostic indicator for HB. Conclusion: To the best of our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the diagnostic and prognostic role of dysregulated miRNAs in HB patients. The combined meta-analysis results supported the previous individual finds that miRNAs might provide a new, noninvasive method for the diagnostic and prognostic analyses ofHB.

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