scholarly journals Success of Thrombectomy in Management of Ischemic Stroke in Two Patients with SynCardia Total Artificial Heart in Bridge-to-Transplantation

2021 ◽  
Vol 8 (9) ◽  
pp. 126
Author(s):  
Brendan Le Picault ◽  
Charles-Henri David ◽  
Pierre-Louis Alexandre ◽  
Cédric Lenoble ◽  
Philippe Bizouarn ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Report ◽  
Artificial Heart ◽  
Mechanical Thrombectomy ◽  
Total Artificial Heart ◽  
Neurological Deficits ◽  
Circulatory Support ◽  
Hemorrhagic Complication ◽  
Bridge To Transplant ◽  
End Stage

Introduction: Circulatory assistance from a SynCardia Total Artificial Heart (SynCardia-TAH) is a reliable bridge-to-transplant solution for patients with end-stage biventricular heart failure. Ischemic strokes affect about 10% of patients with a SynCardia-TAH. We report for the first time in the literature two successful thrombectomies to treat the acute phase of ischemic stroke in two patients treated with a SynCardia-TAH in the bridge-to-transplant (BTT). Case report: We follow two patients with circulatory support from a SynCardia-TAH in the bridge-to-transplant for terminal biventricular cardiac failure with ischemic stroke during the support period. An early in-hospital diagnosis enables the completion of a mechanical thrombectomy within the first 6 h of the onset of symptoms. There was no intracranial hemorrhagic complication during or after the procedure and the patients fully recovered from neurological deficits, allowing a successful heart transplant. Conclusion: This case report describes the possibility of treating ischemic strokes under a SynCardia-TAH by mechanical thrombectomy following the same recommendations as for the general population with excellent results and without any hemorrhagic complication during or after the procedure.

scholarly journals Hybrid membranes for the production of blood contacting surfaces: physicochemical, structural and biomechanical characterization

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Martina Todesco ◽  
Carlo Zardin ◽  
Laura Iop ◽  
Tiziana Palmosi ◽  
Pietro Capaldo ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Point Of View ◽  
Total Artificial Heart ◽  
Circulatory Support ◽  
Hybrid Membranes ◽  
Ventricular Assist ◽  
Actuation System ◽  
Mechanical Circulatory Support Devices ◽  
End Stage ◽  
Porcine Pericardium

Abstract Background Due to the shortage of organs’ donors that limits biological heart transplantations, mechanical circulatory supports can be implanted in case of refractory end-stage heart failure to replace partially (Ventricular Assist Device, VAD) or completely (Total Artificial Heart, TAH) the cardiac function. The hemocompatibility of mechanical circulatory supports is a fundamental issue that has not yet been fully matched; it mostly depends on the nature of blood-contacting surfaces. Methods In order to obtain hemocompatible materials, a pool of hybrid membranes was fabricated by coupling a synthetic polymer (polycarbonate urethane, commercially available in two formulations) with a decellularized biological tissue (porcine pericardium). To test their potential suitability as candidate materials for realizing the blood-contacting surfaces of a novel artificial heart, hybrid membranes have been preliminarily characterized in terms of physicochemical, structural and mechanical properties. Results Our results ascertained that the hybrid membranes are properly stratified, thus allowing to expose their biological side to blood and their polymeric surface to the actuation system of the intended device. From the biomechanical point of view, the hybrid membranes can withstand deformations up to more than 70 % and stresses up to around 8 MPa. Conclusions The hybrid membranes are suitable for the construction of the ventricular chambers of innovative mechanical circulatory support devices.

Case report: Neuropsychological therapy for patient with a total artificial heart

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
Y Brocks ◽  
M Schoenbrodt ◽  
M Morshuis ◽  
J Gummert ◽  
K Tigges-Limmer
Keyword(s):  
Case Report ◽  
Artificial Heart ◽  
Total Artificial Heart

scholarly journals Loeffler's Endocarditis Treated with Total Artificial Heart as Bridge to Transplant

2021 ◽  
Vol 40 (4) ◽  
pp. S528
Author(s):  
G.T. Gibson ◽  
S. Rangasamy ◽  
J. Contreras ◽  
A. Singhvi ◽  
A. Fox ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Total Artificial Heart ◽  
Bridge To Transplant

305 Bridge to Transplant Using BiVAD or Total Artificial Heart: Is There a Survival Difference?

2012 ◽  
Vol 31 (4) ◽  
pp. S109-S110
Author(s):  
A. Nguyen ◽  
M. Pozzi ◽  
C. Mastroianni ◽  
P. Leprince ◽  
P. Alain ◽  
...  
Keyword(s):  
Artificial Heart ◽  
Total Artificial Heart ◽  
Bridge To Transplant ◽  
Survival Difference

Mechanical thrombectomy beyond the circle of Willis: efficacy and safety of different techniques for M2 occlusions

2021 ◽  
pp. neurintsurg-2021-017425
Author(s):  
Leonardo Renieri ◽  
Iacopo Valente ◽  
Adam A Dmytriw ◽  
Ajit S Puri ◽  
Jasmeet Singh ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Clinical Outcome ◽  
Mechanical Thrombectomy ◽  
Circle Of Willis ◽  
Stent Retriever ◽  
National Institutes Of Health ◽  
Neurological Deficits ◽  
Stent Retrievers ◽  
Subarachnoid Hemorrhages ◽  
Combined Technique

BackgroundM2 segment occlusions represent approximately one-third of non-lacunar ischemic stroke and can lead to permanent neurological deficits. Various techniques are available for mechanical thrombectomy beyond the circle of Willis, but data evaluating their effectiveness and safety are lacking.MethodsA retrospective review of patients with ischemic stroke undergoing mechanical thrombectomy for M2 occlusions from 13 centers in North American and Europe was performed. Tandem or multiple-territory occlusions were excluded. The primary outcome was 90-day modified Rankin Scale and reperfusion rates across stent-retriever, direct aspiration and combined techniques.ResultsThere were 465 patients (mean age 71.48±14.03 years, 53.1% female) with M2 occlusions who underwent mechanical thrombectomy. Stent-retriever alone was used in 133 (28.6%), direct aspiration alone in 93 (20.0%) and the combined technique in 239 (51.4%) patients. Successful reperfusion was achieved with the combined technique in 198 (82.2%; OR 2.6 (1.1–6.9)), with stent-retriever alone in 112 (84.2%; OR 9.2 (1.9–44.6)) and with direct aspiration alone in 62 (66.7%; referencecategory). Intraprocedural subarachnoid hemorrhages (iSAH) were 36 (7.7%) and were more likely to occur in patients treated with the stent-retrievers (OR 5.0 (1.1–24.3)) and combined technique (OR 4.6 (1.1–20.9)). Good clinical outcome was achieved in 260 (61.8%) patients, while 59 (14.0%) patients died. Older age, higher baseline NIHSS (National Institutes of Health Stroke Scale), parenchymal hemorrhage and iSAH were associated with poor outcome while successful recanalization and higher baseline ASPECTS (Alberta Stroke Program Early CT Score) were associated with good outcome. No differences were found among the three techniques in terms of clinical outcome.ConclusionStent-retrievers and a combined approach for M2 occlusions seem more effective than direct aspiration, but with higher rates of iSAH. This leads to no detectable difference in clinical outcome at 3 months.

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