Marine Natural Products with Antifouling Activity

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  

Author(s):  
K. F. Albizati ◽  
V. A. Martin ◽  
M. R. Agharahimi ◽  
D. A. Stolze

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.


2016 ◽  
Vol 23 (4) ◽  
pp. 360-382 ◽  
Author(s):  
Mousa Alghazwi ◽  
Yen Qi Kan ◽  
Wei Zhang ◽  
Wei Ping Gai ◽  
Xiao-Xin Yan

2018 ◽  
Vol 25 (20) ◽  
pp. 2304-2328 ◽  
Author(s):  
Lishu Wang ◽  
Jungfeng Wang ◽  
Juan Liu ◽  
Yonghong Liu

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.


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