Antitubercular Marine Natural Products

2018 ◽  
Vol 25 (20) ◽  
pp. 2304-2328 ◽  
Author(s):  
Lishu Wang ◽  
Jungfeng Wang ◽  
Juan Liu ◽  
Yonghong Liu
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Antitubercular Activity ◽  
Marine Resources ◽  
Drug Candidates ◽  
New Drug ◽  
Chemical Constitution

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.

scholarly journals Marine Natural Products Against Tuberculosis

2006 ◽  
Vol 6 ◽  
pp. 847-861 ◽  
Author(s):  
Marcus Vinícius Nora De Souza
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Human Diseases ◽  
Antituberculosis Activity ◽  
Drug Candidates ◽  
New Drug

Natural products represent an outstanding source of compounds that play an important role in the treatment of human diseases. Due to the importance of nature as a source of new drug candidates, the aim of this review is to highlight the marine natural products, which exhibit antituberculosis activity, discovered between 2000 and 2005.

Natural Products in the Process of Finding New Drug Candidates

2004 ◽  
Vol 11 (11) ◽  
pp. 1375-1389 ◽  
Author(s):  
P. Vuorela ◽  
M. Leinonen ◽  
P. Saikku ◽  
P. Tammela ◽  
J.- Rauha ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Candidates ◽  
New Drug

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 239-250 ◽  
Author(s):  
Helineide Cristina Campos ◽  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Parkinsons Disease ◽  
Drug Candidates ◽  
New Drug

Antitumor Potential of Marine Natural Products: A Mechanistic Investigation

2018 ◽  
Vol 18 (5) ◽  
pp. 702-718 ◽  
Author(s):  
Liping Hu ◽  
Jie Ying ◽  
Miaomiao Zhang ◽  
Xiaoyan Qiu ◽  
Yu Lu
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Resources ◽  
Advanced Cancer Patients ◽  
Antitumor Effects ◽  
Terrestrial Environment ◽  
The Past ◽  
Mechanistic Investigation ◽  
Lower Oxygen ◽  
Effective Drugs

Background: Compounds obtained from natural resources have become important candidates in the discovery and development of drugs. Over the past few decades, marine resources have gradually attracted a large amount of attention from researchers, and many compounds with varying structures and activities have been derived from various marine resources. Since the ocean experiences more variable temperatures, lower oxygen levels and less light than the terrestrial environment, marine resources offer a substantial number of organisms that are not available or rarely detected on land. </P><P> Description: Researchers expect that they can discover agents from marine organisms that exhibit good activity for diseases. Of the marine compounds acquired, the majority have shown to have good antitumor activity, and range in phases from clinical trials up to being used in the clinic. These natural products operate through different pathways and have unique antitumor effects that include inducing cell apoptosis, inhibiting cell proliferation and influencing cell migration. A variety of drugs have been used for cancer treatment during the last few years, but it has not been possible to greatly extend the survival time of advanced cancer patients. In addition, researchers are actively looking for compounds to overcome problems that include a lack of effective drugs to control the transfer of cancer cells and the development of drug-resistant microbes. Conclusion: Here, we summarize the marine natural products that have been obtained over the past few years, and analyze their antitumor effects and mechanisms. Our research will provide a significant basis for anticancer drug screening and development.

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 251-270 ◽  
Author(s):  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Helineide Cristina Campos ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Alzheimers Disease ◽  
Drug Candidates ◽  
New Drug

Advances in identification and validation of protein targets of natural products without chemical modification

2016 ◽  
Vol 33 (5) ◽  
pp. 719-730 ◽  
Author(s):  
J. Chang ◽  
Y. Kim ◽  
H. J. Kwon
Keyword(s):  
Natural Products ◽  
Chemical Modification ◽  
Case Studies ◽  
Protein Identification ◽  
Target Protein ◽  
Label Free ◽  
Protein Targets ◽  
Identification Methods ◽  
Drug Candidates ◽  
New Drug

This review focuses on and reports case studies of the latest advances in target protein identification methods for label-free natural products. The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates.

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach
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