scholarly journals Symptoms of Autism Spectrum Disorder in Individuals with Down Syndrome

2021 ◽  
Vol 11 (10) ◽  
pp. 1278
Author(s):  
Amanda Dimachkie Nunnally ◽  
Vivian Nguyen ◽  
Claudine Anglo ◽  
Audra Sterling ◽  
Jamie Edgin ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Expressive Language ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Spectrum ◽  
Language Abilities ◽  
The Social ◽  
Item Level ◽  
Spectrum Disorders ◽  
Shed Light ◽  
Autism Diagnostic Observation

There is a growing body of evidence to suggest that individuals with Down syndrome (DS) are diagnosed with autism spectrum disorders (ASD) at a higher rate than individuals in the general population. Nonetheless, little is known regarding the unique presentation of ASD symptoms in DS. The current study aims to explore the prevalence and profiles of ASD symptoms in a sample of individuals with DS (n = 83), aged between 6 and 23 years. Analysis of this sample (MAge = 15.13) revealed that approximately 37% of the sample met the classification cut-off for ASD using the Autism Diagnostic Observation Schedule 2 (ADOS-2) Calibrated Severity Score (CSS), an indicator of the participants’ severity of ASD-related symptoms. Item-level analyses revealed that multiple items on Module 2 and Module 3 of the ADOS-2, mostly in the Social Affect (SA) subdomain, differentiated the children with DS who did not meet ASD classification (DS-only) from those who did (DS + ASD). Lastly, comparisons of individuals with DS-only and those with DS + ASD differed significantly on the syntactic complexity of their expressive language. These findings shed light on the unique presentation of ASD symptoms in a sample of individuals with DS and suggest that expressive language abilities may play a pivotal role in the presentation of ASD symptoms in DS.

A Meta-analysis of the Diagnostic Accuracy of Autism Diagnostic Observation Schedule Module-1 for Autism Spectrum Disorders

2014 ◽  
Vol 81 (S2) ◽  
pp. 187-192 ◽  
Author(s):  
Sherab Tsheringla ◽  
K. A. Minju ◽  
Sushila Russell ◽  
Priya Mammen ◽  
Paul Swamidhas Sudhakar Russell ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Diagnostic Accuracy ◽  
Meta Analysis ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Spectrum ◽  
Spectrum Disorders ◽  
Autism Diagnostic Observation

scholarly journals Recurrence Risk for Autism Spectrum Disorders: A Baby Siblings Research Consortium Study

2021 ◽  
Vol 271 ◽  
pp. 03071
Author(s):  
Valeria Li Tang
Keyword(s):  
Autism Spectrum Disorders ◽  
Severe Disease ◽  
Recurrence Risk ◽  
Autism Diagnostic Observation Schedule ◽  
Autism Spectrum ◽  
Family Education ◽  
Spectrum Disorders ◽  
Research Consortium ◽  
Core Symptoms ◽  
Autism Diagnostic Observation

Autism spectrum disorder (ASD) is defined based on the core symptoms of typical autism. It is considered to be a congenital mental disorder and has nothing to do with acquired family education. Children with this disease have difficulties in social interaction, communication, and repetitive behaviours [3]. Since it is a severe disease that hinder the development of children, the risk factors of this disease are worth being investigated. One known risk factor is the gender. However, other risks are not defined yet such as the recurrence risk in siblings. Therefore, the author tried to figure out this risk. This paper reviewed a study done in 2011 about the recurrence risk for autism spectrum disorders in siblings. A longitudinal study was used, meaning that the same test subjects were examined over a period of time. The autism diagnostic observation schedule (ADOS), the standard diagnostic test for ASD was used in this study to determine whether a child is diagnosed with ASD. The results were estimated through parameters of a model numerically by an iterative fitting process. It was found through this research that there was indeed a correlation between children who had siblings with ASD and having ASD themselves.

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