scholarly journals Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 606 ◽  
Author(s):  
Markus Notter ◽  
Andreas R. Thomsen ◽  
Mirko Nitsche ◽  
Robert M. Hermann ◽  
Hendrik A. Wolff ◽  
...  

Effective tumor control in patients suffering from unresectable locally recurrent breast cancer (LRBC) in pre-irradiated areas can be achieved by re-irradiation combined with superficial hyperthermia. Using this combined modality, total re-irradiation dose and toxicity can be significantly reduced compared to conventionally fractionated treatment schedules with total doses of 60–66 Gy. Applying contact-free, thermography-controlled water-filtered infrared-A superficial hyperthermia, immediately followed by hypofractionated re-irradiation, consisting of 4 Gy once per week up to a total dose of 20 Gy, resulted in high overall response rates even in large-sized tumors. Comparability of clinical data between different combined Hyperthermia (HT)/Radiotherapy (RT) treatment schedules is impeded by the highly individual characteristics of this disease. Tumor size, ranging from microscopic disease and small lesions to large-sized cancer en cuirasse, is described as one of the most important prognostic factors. However, in clinical studies and analyses of LRBC, tumor size has so far been reported in a very heterogeneous way. Therefore, we suggest a novel, simple and feasible size classification (rClasses 0–IV). Applying this classification for the evaluation of 201 patients with pre-irradiated LRBC allowed for a stratification into distinct prognostic groups.

1997 ◽  
Vol 84 (8) ◽  
pp. 1147-1151 ◽  
Author(s):  
H. Mumtaz ◽  
T. Davidson ◽  
M. A. Hall-Craggs ◽  
M. Payley ◽  
K. Walmsley ◽  
...  

2020 ◽  
Vol 70 (2) ◽  
pp. 119-122
Author(s):  
Akiko Morishita ◽  
Takashi Yoshida ◽  
Yoshinari Goto

2016 ◽  
Vol 119 ◽  
pp. S22-S23
Author(s):  
E. Bräutigam ◽  
C. Track ◽  
M. Geier ◽  
H. Geinitz

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