scholarly journals Alterations of Chromatin Regulators in the Pathogenesis of Urinary Bladder Urothelial Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6040
Author(s):  
Michèle J. Hoffmann ◽  
Wolfgang A. Schulz
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Checkpoint Control ◽  
Genetic Changes ◽  
Genomic Changes ◽  
Chromatin Regulators ◽  
Chromatin Remodeling Complex ◽  
Bladder Urothelial Carcinoma ◽  
Histone Modifying Enzymes ◽  
Gene Expression Alterations

Urothelial carcinoma (UC) is the most frequent histological type of cancer in the urinary bladder. Genomic changes in UC activate MAPK and PI3K/AKT signal transduction pathways, which increase cell proliferation and survival, interfere with cell cycle and checkpoint control, and prevent senescence. A more recently discovered additional category of genetic changes in UC affects chromatin regulators, including histone-modifying enzymes (KMT2C, KMT2D, KDM6A, EZH2), transcription cofactors (CREBBP, EP300), and components of the chromatin remodeling complex SWI/SNF (ARID1A, SMARCA4). It is not yet well understood how these changes contribute to the development and progression of UC. Therefore, we review here the emerging knowledge on genomic and gene expression alterations of chromatin regulators and their consequences for cell differentiation, cellular plasticity, and clonal expansion during UC pathogenesis. Our analysis identifies additional relevant chromatin regulators and suggests a model for urothelial carcinogenesis as a basis for further mechanistic studies and targeted therapy development.

EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma

2021 ◽  
Author(s):  
Chien-Feng Li ◽  
Ti-Chun Chan ◽  
Cheng-Tang Pan ◽  
Pichpisith Pierre Vejvisithsakul ◽  
Jia-Chen Lai ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals A Case of Urinary Bladder Urothelial Carcinoma with Squamous, Glandular, and Plasmacytoid Differentiation

2014 ◽  
Vol 7 (2) ◽  
pp. 362-368 ◽  
Author(s):  
Naohiro Makise ◽  
Teppei Morikawa ◽  
Yuta Takeshima ◽  
Yukio Homma ◽  
Masashi Fukayama
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

scholarly journals Galactin-1 Dysregulation is Predict Factor to Prognosis of Urinary Bladder Urothelial Carcinoma

2015 ◽  
Vol 26 (2) ◽  
pp. S13
Author(s):  
Kun-Lin Hsieh ◽  
Chi-Cheng Su ◽  
Kun-Hung Shen ◽  
Ting-Feng Wu
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Bladder Urothelial Carcinoma

Diagnosis of urinary bladder urothelial carcinoma by immunocytology with p53, MCM 5, MCM 2 and Ki‐67 antibodies using cell blocks derived from urine

Cytopathology ◽  
2019 ◽  
Vol 30 (5) ◽  
pp. 510-518
Author(s):  
Antonín Brisuda ◽  
Jaromír Háček ◽  
Marcela Čechová ◽  
Petr Škapa ◽  
Marek Babjuk
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Ki 67 ◽  
Bladder Urothelial Carcinoma

Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells

2018 ◽  
Vol 119 (6) ◽  
pp. 4592-4606 ◽  
Author(s):  
Sheng-Yuan Huang ◽  
Chih-Cheng Chien ◽  
Ruey-Shyang Hseu ◽  
Victoria Ying Jen Huang ◽  
Shang Ying Chiang ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Mitomycin C ◽  
Carcinoma Cells ◽  
Bladder Urothelial Carcinoma ◽  
Immunomodulatory Protein ◽  
Induced Apoptosis

scholarly journals Deciphering the Molecular Mechanism Underlying the Inhibitory Efficacy of Taiwanese Local Pomegranate Peels against Urinary Bladder Urothelial Carcinoma

Nutrients ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 543 ◽  
Author(s):  
Ching-Ping Chang ◽  
Yu-Yi Chan ◽  
Chien-Feng Li ◽  
Lan-Hsiang Chien ◽  
Song-Tay Lee ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Molecular Mechanism ◽  
Bladder Urothelial Carcinoma

scholarly journals Yolk Sac tumor differentiation in urothelial carcinoma of the urinary bladder: A case report and differential diagnosis

2020 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Enric Condom Mundó
Keyword(s):  
Differential Diagnosis ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Final Diagnosis ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
High Grade ◽  
Predominant Component ◽  
Bladder Urothelial Carcinoma ◽  
Urinary Bladder Tumor

Abstract Background: Yolk sac tumor (YST) is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These latter cases have been documented in several organs, although reports from the urinary tract are limited. To our knowledge, this is the first report of a bladder urothelial carcinoma with a predominant component of YST differentiation.Case presentation: We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negativity for CK7 and EMA. Fluorescent in situ hybridization study showed a polysomic pattern of chromosome 12. All these findings led to the final diagnosis of a YST derived from urothelial carcinoma. Conclusions: YST differentiation should be considered in the differential diagnosis of a high grade urothelial carcinoma, particularly when glandular and other unusual patterns are observed.

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