scholarly journals The Overall Quality of Life and Oncological Outcomes Following Radical Hysterectomy in Cervical Cancer Survivors Results from a Large Long-Term Single-Institution Study

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 317
Author(s):  
Mihai Stanca ◽  
Dan Mihai Căpîlna ◽  
Cristian Trâmbițaș ◽  
Mihai Emil Căpîlna
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Survivors ◽  
Radical Hysterectomy ◽  
Gynecological Cancer ◽  
Sexual Life ◽  
Eastern European ◽  
Cox Regression Analysis

(1) Background: Cervical cancer patients have been found to have worse quality of life (QoL) scores due to cancer treatment, not only when compared to the general population, but also when compared to other gynecological cancer survivors. In Eastern European developing countries, the health care system often cannot afford the uppermost standardized treatment for these patients. In the absence of a comparable study in our country, the authors’ aim for this retrospective cross-sectional observational study was to evaluate the overall survival (OS) and the QoL o cervical cancer survivors; (2) Methods: 430 patients were analyzed. The first objective is to evaluate the OS rates of patients with cervical cancer stages IA2 to IIB undergoing radical hysterectomy (RH) +/− neoadjuvant or adjuvant radiotherapy +/− chemoradiotherapy treatment combinations. The second objective is to assess their QoL, using two standardized questionnaires issued by the European Organisation for Research and Treatment of Cancer (EORTC), namely QLQ-C30 and QLQ-CX24. (3) Results: The mean age of the participants was 51 years (22–76) and the average follow-up time was 65 months (2–128). At the time of the analysis, 308 out of 430 patients were alive, with a mean five-year OS of 72.4%. The multivariate Cox regression analysis identified stage IIB, parametrial invasion, and the lymph node metastases as independent prognostic risk factors negatively impacting the OS. Of the 308 patients still alive at the time of the analysis, 208 (68%) answered the QoL questionnaires. The QLQ-C30 shows a good long-term Global QoL of 64.6 (median), good functioning scores, and a decent symptom scale value. However, the EORTC QLQ-CX24 showed high values of cervical cancer-specific symptoms, namely: lymphedema, peripheral neuropathy, severe menopausal symptoms, and distorted body-image perception. The results also indicate a significant decline in the quality of sexual life with a low sexual enjoyment and decreased level of sexual activities. (4) Conclusion: Despite a good OS, in this setting of patients, cervical cancer survivors have a modest QoL and sexual function. Our study may provide a comparison for future randomized, controlled trials in Eastern European countries needing to confirm these results.

Quality of life and disparities among long-term cervical cancer survivors

2014 ◽  
Vol 8 (3) ◽  
pp. 419-426 ◽  
Author(s):  
Howard P. Greenwald ◽  
Ruth McCorkle ◽  
Kathy Baumgartner ◽  
Carolyn Gotay ◽  
Anne Victoria Neale
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Survivors

scholarly journals Quality of life in long-term cervical cancer survivors

2005 ◽  
Vol 97 (2) ◽  
pp. 310-317 ◽  
Author(s):  
Lari Wenzel ◽  
Israel DeAlba ◽  
Rana Habbal ◽  
Brenda Coffey Kluhsman ◽  
Diane Fairclough ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Survivors

Fecal Incontinence Affecting Quality of Life and Social Functioning Among Long-Term Gynecological Cancer Survivors

2010 ◽  
Vol 20 (3) ◽  
pp. 449-460 ◽  
Author(s):  
Gail Dunberger ◽  
Helena Lind ◽  
Gunnar Steineck ◽  
Ann-Charlotte Waldenström ◽  
Tommy Nyberg ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Fecal Incontinence ◽  
Cancer Survivors ◽  
Social Functioning ◽  
Gynecological Cancer ◽  
Gynecological Cancer Survivors

Quality of Life and Sexual Functioning in Cervical Cancer Survivors

2005 ◽  
Vol 23 (30) ◽  
pp. 7428-7436 ◽  
Author(s):  
Michael Frumovitz ◽  
Charlotte C. Sun ◽  
Leslie R. Schover ◽  
Mark F. Munsell ◽  
Anuja Jhingran ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Survivors ◽  
Radical Hysterectomy ◽  
Sexual Functioning ◽  
Univariate Analysis ◽  
Node Dissection ◽  
History Of ◽  
History Of Cancer

Purpose To compare quality of life and sexual functioning in cervical cancer survivors treated with either radical hysterectomy and lymph node dissection or radiotherapy. Methods Women were interviewed at least 5 years after initial treatment for cervical cancer. Eligible women had squamous cell tumors smaller than 6 cm at diagnosis, were currently disease-free, and had either undergone surgery or radiotherapy, but not both. The two treatment groups were then compared using univariate analysis and multivariate linear regression with a control group of age- and race-matched women with no history of cancer. Results One hundred fourteen patients (37 surgery, 37 radiotherapy, 40 controls) were included for analysis. When compared with surgery patients and controls using univariate analysis, radiation patients had significantly poorer scores on standardized questionnaires measuring health-related quality of life (physical and mental health), psychosocial distress and sexual functioning. The disparity in sexual function remained significant in a multivariate analysis. Univariate and multivariate analyses did not show significant differences between radical hysterectomy patients and controls on any of the outcome measures. Conclusion Cervical cancer survivors treated with radiotherapy had worse sexual functioning than did those treated with radical hysterectomy and lymph node dissection. In contrast, these data suggest that cervical cancer survivors treated with surgery alone can expect overall quality of life and sexual function not unlike that of peers without a history of cancer.

Assessment of Quality of Life and Urinary and Sexual Function After Radical Hysterectomy in Long-Term Cervical Cancer Survivors

2018 ◽  
Vol 28 (4) ◽  
pp. 818-823 ◽  
Author(s):  
Francesco Plotti ◽  
Corrado Terranova ◽  
Stella Capriglione ◽  
Stefania Crispino ◽  
Alessandra Li Pomi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Sexual Function ◽  
Sexual Activity ◽  
Radical Hysterectomy ◽  
European Organization ◽  
Type Iii

AimsThe aim of this study was to evaluate long-term quality of life and urinary and sexual function in long-term cervical cancer survivors previously treated with radical hysterectomy (RH) type C2/type III.MethodsAll patients who presented at Campus Bio-Medico of Rome for RH type C2/type III for cervical cancer were considered eligible for this retrospective study protocol. We included exclusively patients with complete response to primary treatment with at least 36 months of follow up. Included subjects were interviewed with the European Organization for Research and Treatment of Cancer QLQ-CX24 Questionnaire, European Organization for Research and Treatment of Cancer QLQ-C30, and an Incontinence Impact Questionnaire 7.ResultsFrom January 2004 to June 2014, 251 patients affected by locally advanced cervical cancer were treated at Campus Bio-Medico of Rome treated with type C2/type III RH. At time point of March 2017, 90 patients were included with a mean age of 55.6 ± 8.5 years. The questionnaires were administered after a median follow-up of 49 months after the end of therapy. The symptoms of fatigue, nausea and vomiting, appetite loss, pain, insomnia, and dyspnea, as well as a negative financial impact, were reported as not frequent and rarely disabling. On the contrary, patients frequently reported gastrointestinal complaints. Diarrhea was present in 6% of patients and was referred as mild; constipation was present in 75% of women and was reported as mild in 30% of cases, moderate in 30%, and severe in 15%. Concerning sexual activity, data indicated a good level of sexual enjoyment with a slight worsening of sexual activity. Incontinence was reported in 28% of cases and appeared to be mild and rarely disabling (all mean values <2).ConclusionsWaiting for ongoing randomized controlled trials, this study confirmed that RH may be considered as a useful treatment plan, according to its negligible long-term impact on quality of life, urinary dysfunction, and sexual function.

Quality of life in long-term cervical cancer survivors: A population-based study

2013 ◽  
Vol 129 (1) ◽  
pp. 222-228 ◽  
Author(s):  
Gwenael Le Borgne ◽  
Mariette Mercier ◽  
Anne-Sophie Woronoff ◽  
Anne-Valérie Guizard ◽  
Edwige Abeilard ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Cancer Survivors ◽  
Population Based ◽  
Population Based Study
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