scholarly journals Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1063
Author(s):  
Chien-Heng Lin ◽  
Sheng-Shing Lin ◽  
Syuan-Yu Hong ◽  
Chieh-Ho Chen ◽  
I-Ching Chou
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Skin Rash ◽  
Stable Condition ◽  
Anticonvulsant Drug ◽  
Dress Syndrome ◽  
Life Threatening ◽  
History Of ◽  
History Of Epilepsy ◽  
Systemic Symptoms

Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

scholarly journals Lamotrigine induced DRESS syndrome in a child: a case report and literature review

2021 ◽  
Author(s):  
Chien-Heng Lin ◽  
Sheng-Shing Lin ◽  
Syuan-Yu Hong ◽  
Chieh-Ho Chen ◽  
I-Ching Chou
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Literature Review ◽  
Skin Rash ◽  
Anticonvulsant Drug ◽  
Dress Syndrome ◽  
Life Threatening ◽  
History Of ◽  
History Of Epilepsy ◽  
Systemic Symptoms

Abstract BackgroundLamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).Case presentationHere, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in stable condition.ConclusionAnticonvulsant drugs such as lamotrigine among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.

scholarly journals Drug reaction with eosinophilia and systemic symptom induced by carbamazepine: a case report

2019 ◽  
Vol 8 (5) ◽  
pp. 1115
Author(s):  
Rahul R. Damor ◽  
Amita R. Kubavat ◽  
Kiran G. Piparva
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Antiepileptic Drugs ◽  
Drug Exposure ◽  
Latency Period ◽  
Systemic Symptom ◽  
Dress Syndrome ◽  
Period 2 ◽  
Life Threatening ◽  
Systemic Symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe, potentially life-threatening acute adverse drug reaction (ADR), typically characterized by a long latency period (2-6 weeks to 3 months) from drug exposure. DRESS syndrome is defined by the presence of fever, cutaneous eruption, lymphadenopathy, systemic or asymptomatic internal organ involvement (e.g. Hepatitis, carditis, interstitial nephritis, interstitial pneumonitis, etc.) and haematological abnormalities, mainly leucocytosis, eosinophilia and sometimes atypical lymphocytosis. There are around 50 culprit drugs which cause DRESS syndrome e.g. carbamazepine, phenytoin, allopurinol, sulfa derivatives, antidepressants, antiepileptics, non-steroidal anti-inflammatory drugs and antimicrobials. The incidence of DRESS syndrome has been estimated to be between 1 in 1,000 and 1 in 10,000 drug exposures. There are many reported cases of DRESS syndrome due to carbamazepine, phenytoin, vancomycin, levitiracitam, ceftriaxone etc. Author presented a case of DRESS syndrome by carbamazepin. RegiSCAR and Japanese consensus group have developed specific criteria for making the diagnosis of DRESS syndrome. The patient described here met the majority of criteria according to RegiSCAR scoring guidelines for a diagnosis of DRESS syndrome induced by carbamazepine. As per RegiSCAR diagnostic criteria author had concluded that this was a “Definite” case of DRESS (Drug Reaction with Eosinophilia and Systemic Symptom) syndrome induced by carbamazepine. Carbamazepine is most common broad-spectrum antiepileptic drugs so, this case report will raises awareness among physician to suspect DRESS syndrome in patients who present unusual complaints and skin findings after starting antiepileptic drugs.

scholarly journals Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by ceftriaxone with successful treatment — A case report and literature review

2022 ◽  
Vol 8 (4) ◽  
pp. 298-300
Author(s):  
Arpit Agrawal ◽  
Pankaj Kannauje
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Literature Review ◽  
Sore Throat ◽  
Hypersensitivity Reactions ◽  
Dress Syndrome ◽  
Threatening Condition ◽  
Life Threatening ◽  
Systemic Symptoms ◽  
Prolonged Latency

Drug reaction with eosinophilia and systemic symptoms is a rare and potentially life threatening condition characterised by hypersensitivity reactions to a drug with prolonged latency, in the form of skin rashes, hyper eosinophilia and systemic features like fever, lymphadenopathy, leucocytosis, internal organ involvement (liver, kidney, lung). Though it can occur in response to many drugs but very few cases has been described in relation to one of the most commonly used antibiotic ceftriaxone. Here we have described a case of DRESS in a patient who has been treated with ceftriaxone outside our hospital for sore throat.

scholarly journals DRESS syndrome due to clobazam: a case report

2020 ◽  
Vol 9 (12) ◽  
pp. 1906
Author(s):  
M. Faraz Qureshi ◽  
A. N. Dattatari
Keyword(s):  
Case Report ◽  
Hypersensitivity Reaction ◽  
Seizure Disorder ◽  
Dress Syndrome ◽  
Internal Organs ◽  
Idiosyncratic Reaction ◽  
Life Threatening ◽  
History Of ◽  
Drug Rash ◽  
Systemic Symptoms

Drug rash (or reaction) with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to drugs characterized by rash, fever, lymphadenopathy, hematologic abnormalities, and involvement of internal organs. Initially coined in 1996, the term is used to refer to an idiosyncratic reaction to several drugs, the most common of which are carbamazepine, allopurinol, sulfasalazine, and phenobarbital. We report the case of DRESS related to clobazam in a 38-year-old female with a history of a complex seizure disorder.

scholarly journals Case Report: Alpelisib-Induced Drug Reaction With Eosinophilia and Systemic Symptoms: A Rare Manifestation of a Common Side Effect

2021 ◽  
Vol 11 ◽  
Author(s):  
Umair Majeed ◽  
Tudor Puiu ◽  
Jason Sluzevich ◽  
Gina Reynolds ◽  
Marites Acampora ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Side Effect ◽  
Common Side Effect ◽  
Dress Syndrome ◽  
Initial Exposure ◽  
First Case ◽  
Rare Manifestation ◽  
Life Threatening ◽  
Systemic Symptoms

Alpelisib is a PIK3a inhibitor approved for the treatment of metastatic ER+ breast cancer in combination with fulvestrant. Although rash is a common side effect of this medication, we present the first case of drug reaction with eosinophilia and systemic symptoms (DRESS) upon initial exposure to alpelisib. Here we describe the clinical-pathological findings and management of our patient with alpelisib-induced life-threatening DRESS syndrome. The goal of this case report is to highlight association of alpelisib with DRESS syndrome, in clinical practice, so that alpelisib can be immediately stopped and treatment for this serious condition promptly initiated.

scholarly journals Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)

2016 ◽  
Vol 62 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Soraia Aparecida da Silva ◽  
Mariana Maciel Pereira de Figueiredo ◽  
Lauro Carneiro Neto ◽  
Débora Borowiak Reiss ◽  
Mariana Amaranto de Souza Damásio
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Literature Review ◽  
Hypersensitivity Reaction ◽  
Laboratory Tests ◽  
Immune Status ◽  
Target Organ ◽  
Dress Syndrome ◽  
Risk Of Mortality ◽  
Systemic Symptoms

SUMMARY Objective: To review the hypersensitivity reaction to drugs known as drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), based on a case report. We also intend to discuss the difficulty and importance of disease recognition, since none of the changes is pathognomonic of this disease and failure to identify it may have disastrous consequences for the patient. Method: To describe this case report, in addition to the information collected for clinical assessment, a literature review was performed in the PubMed and Bireme databases in order to retrieve the latest information published in literature on DRESS syndrome. Results: The case of a 20-year old patient is reported. After anamnesis, physical examination and laboratory tests a diagnosis of DRESS syndrome was performed, characterized by rash, hematologic alterations, lymphadenopathy and lesions in target organ. This is a rare syndrome, whose frequency varies according to the drug used and the immune status of the patient, being more often associated with the use of anticonvulsants. Conclusion: The approach and discussion of the topic are of paramount importance, in view of the potential lethality of this treatable syndrome. Recognizing the occurrence of DRESS syndrome and starting treatment as soon as possible is crucial to reduce the risk of mortality and improve prognosis.

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report

2017 ◽  
Vol 28 ◽  
Author(s):  
Burcu Karakayali ◽  
Ahmet Sami Yazar ◽  
Deniz Çakir ◽  
Aysen Cetemen ◽  
Mandana Kariminikoo ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Dress Syndrome ◽  
Systemic Symptoms

scholarly journals Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature

2018 ◽  
Vol 19 ◽  
pp. 163-170 ◽  
Author(s):  
Jared James ◽  
Yasser M. Sammour ◽  
Andrew R. Virata ◽  
Terri A. Nordin ◽  
Igor Dumic
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Review Of Literature ◽  
Dress Syndrome ◽  
Systemic Symptoms

scholarly journals Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)

2008 ◽  
Vol 126 (4) ◽  
pp. 225-226 ◽  
Author(s):  
Renata Telles Rudge de Aquino ◽  
Carmen Silvia Vieitas Vergueiro ◽  
Maria Elisa Ruffolo Magliari ◽  
Thais Helena Proença de Freitas
Keyword(s):  
Drug Reaction ◽  
Case Report ◽  
Mortality Rate ◽  
High Morbidity ◽  
Seronegative Arthritis ◽  
Dress Syndrome ◽  
Brazilian Woman ◽  
Causative Drug ◽  
Drug Rash ◽  
Systemic Symptoms

CONTEXT: DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a type of drug reaction commonly mistaken for a viral infection. It must be recognized promptly due to its high morbidity and 10% mortality rate. Few cases of DRESS syndrome induced by sulfasalazine have been reported in the literature. CASE REPORT: The case of a 47-year-old white Brazilian woman who developed DRESS syndrome eight weeks after starting a course of sulfasalazine for treatment of seronegative arthritis is reported. She presented a skin rash, fever, hepatitis, lymphadenopathy, eosinophilia and atypical lymphocytes. The causative drug was discontinued immediately, but she only improved after treatment with prednisone.

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