scholarly journals Prognostic Value of Ki67 Percentage, WT-1 Expression and p16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study

Diagnostics ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 386 ◽  
Author(s):  
Federica Pezzuto ◽  
Gabriella Serio ◽  
Francesco Fortarezza ◽  
Anna Scattone ◽  
Concetta Caporusso ◽  
...  

Diffuse malignant peritoneal mesothelioma (DMPM) is a rare malignant neoplasm with a poor survival. Although some advances in knowledge have been obtained for the pleural form, much less is known about DMPM. Advantages in terms of prognosis are still limited and strong efforts need to be made. The aim of our study was to correlate several histological and molecular factors with survival in a large cohort of 45 DMPMs. We evaluated histotype, nuclear grade, mitotic count, necrosis, inflammation, desmoplastic reaction, Ki67 percentage, WT-1 expression, p16 protein by immunohistochemistry and CDKN2A deletion by FISH. Our results showed that epithelioid histotype, nuclear grade 2, mitotic count ≤5 x mm2, absence of desmoplasia and p16/CDKN2A deletion, low Ki67 value, and high WT-1 expression were correlated with the most prolonged survival (p = 0.0001). Moreover, p16 loss in immunohistochemistry reflected CDKN2A deletion detected with FISH, and both were correlated with the worst survival (p = 0.0001). At multivariate analysis, Ki67 value, WT-1 expression and p16/CDKN2A deletion emerged as independent prognostic factors (p = 0.01, p = 0.0001 and p = 0.01, respectively). These parameters are easy to analyse at the time of DMPM diagnosis and may support better patient stratification, prediction of treatment effectiveness and therapeutic optimization.

EBioMedicine ◽  
2019 ◽  
Vol 39 ◽  
pp. 215-225 ◽  
Author(s):  
Rocco Sciarrillo ◽  
Anna Wojtuszkiewicz ◽  
Btissame El Hassouni ◽  
Niccola Funel ◽  
Paolo Gandellini ◽  
...  

2013 ◽  
Vol 29 (11) ◽  
pp. 642-645 ◽  
Author(s):  
Chih-An Shih ◽  
Szu-Pei Ho ◽  
Feng-Woei Tsay ◽  
Kwok-Hung Lai ◽  
Ping-I Hsu

2018 ◽  
Vol 44 (6) ◽  
pp. 792-798 ◽  
Author(s):  
Federica Bruno ◽  
Dario Baratti ◽  
Antonia Martinetti ◽  
Daniele Morelli ◽  
Elisa Sottotetti ◽  
...  

2020 ◽  
Vol 13 (11) ◽  
pp. e237721
Author(s):  
Takaaki Tanaka ◽  
Yosuke Miyamoto ◽  
Atsue Sakai ◽  
Nobukazu Fujimoto

Malignant peritoneal mesothelioma (MPeM) is a highly malignant neoplasm of the peritoneum, which carries a poor prognosis. A 70-year-old man, who was employed in the shipbuilding industry and exposed to asbestos for 50 years, was found to have a low-density lesion in the peritoneum around the liver and spleen, associated with multiple mediastinal and parasternal lymphadenopathy. Laparoscopic exploration was performed, and biopsy specimen analysis led to a diagnosis of MPeM. Initial systemic chemotherapy comprising cisplatin and pemetrexed yielded a modest cytoreductive effect. However, 4 months later, the patient presented with abdominal distension and anorexia. CT images revealed massive ascites, bowel obstruction and an enlarged intra-abdominal tumour, which was considered progression of the MPeM. The patient was treated with nivolumab. Bowel obstruction was improved after the first administration, and his sense of abdomen distension completely disappeared after the third administration. This case supports the utility of immunotherapy in MPeM.


1991 ◽  
Vol 41 (2) ◽  
pp. 158-163 ◽  
Author(s):  
Hui-Jun Duan ◽  
Nobuo Itoh ◽  
Osamu Yamagami ◽  
Tsutomu Katsuyama ◽  
Hidekazu Shigematsu

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