scholarly journals Lesion-Based Bone Metastasis Detection in Chest Bone Scintigraphy Images of Prostate Cancer Patients Using Pre-Train, Negative Mining, and Deep Learning

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 518
Author(s):  
Da-Chuan Cheng ◽  
Te-Chun Hsieh ◽  
Kuo-Yang Yen ◽  
Chia-Hung Kao

This study aimed to explore efficient ways to diagnose bone metastasis early using bone scintigraphy images through negative mining, pre-training, the convolutional neural network, and deep learning. We studied 205 prostate cancer patients and 371 breast cancer patients and used bone scintigraphy data from breast cancer patients to pre-train a YOLO v4 with a false-positive reduction strategy. With the pre-trained model, transferred learning was applied to prostate cancer patients to build a model to detect and identify metastasis locations using bone scintigraphy. Ten-fold cross validation was conducted. The mean sensitivity and precision rates for bone metastasis location detection and classification (lesion-based) in the chests of prostate patients were 0.72 ± 0.04 and 0.90 ± 0.04, respectively. The mean sensitivity and specificity rates for bone metastasis classification (patient-based) in the chests of prostate patients were 0.94 ± 0.09 and 0.92 ± 0.09, respectively. The developed system has the potential to provide pre-diagnostic reports to aid in physicians’ final decisions.

2021 ◽  
Author(s):  
Serafeim Moustakidis ◽  
Athanasios Siouras ◽  
Nikolaos Papandrianos ◽  
Charis Ntakolia ◽  
Elpiniki Papageorgiou

2005 ◽  
Vol 8 (1) ◽  
pp. 56
Author(s):  
Jeong Eon Lee ◽  
Hyuk Jai Shin ◽  
Wonshik Han ◽  
Seok Won Kim ◽  
Kyoung Sik Park ◽  
...  

2020 ◽  
Vol 10 (3) ◽  
pp. 997 ◽  
Author(s):  
Nikolaos Papandrianos ◽  
Elpiniki Papageorgiou ◽  
Athanasios Anagnostis ◽  
Anna Feleki

(1) Background: Bone metastasis is one of the most frequent diseases in breast, lung and prostate cancer; bone scintigraphy is the primary imaging method of screening that offers the highest sensitivity (95%) regarding metastases. To address the considerable problem of bone metastasis diagnosis, focused on breast cancer patients, artificial intelligence methods devoted to deep-learning algorithms for medical image analysis are investigated in this research work; (2) Methods: Deep learning is a powerful algorithm for automatic classification and diagnosis of medical images whereas its implementation is achieved by the use of convolutional neural networks (CNNs). The purpose of this study is to build a robust CNN model that will be able to classify images of whole-body scans in patients suffering from breast cancer, depending on whether or not they are infected by metastasis of breast cancer; (3) Results: A robust CNN architecture is selected based on CNN exploration performance for bone metastasis diagnosis using whole-body scan images, achieving a high classification accuracy of 92.50%. The best-performing CNN method is compared with other popular and well-known CNN architectures for medical imaging like ResNet50, VGG16, MobileNet, and DenseNet, reported in the literature, providing superior classification accuracy; and (4) Conclusions: Prediction results show the efficacy of the proposed deep learning approach in bone metastasis diagnosis for breast cancer patients in nuclear medicine.


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