scholarly journals pKa modulation of a bis(2-aminoimidazoline) DNA minor groove binder that targets the kinetoplast of Trypanosoma brucei

2018 ◽  
Author(s):  
Jorge Jonathan Nué Martinez ◽  
Cinthia Millan ◽  
Godwin Ebiloma ◽  
Harry De Koning ◽  
Lourdes Campos ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

scholarly journals Trabectedin – the DNA minor groove binder

2015 ◽  
Vol 2 (2) ◽  
pp. 41
Author(s):  
G. A. Belitsky ◽  
K. I. Kirsanov ◽  
E. A. Lesovaya ◽  
M. G. Yakubovskaya
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

Inhibition of the in vitro integration of moloney murine leukemia virus DNA by the DNA minor groove binder netropsin

1994 ◽  
Vol 47 (10) ◽  
pp. 1821-1826 ◽  
Author(s):  
Sandrine Carteau ◽  
Jean Francois Mouscadet ◽  
Hélène Goulaouic ◽  
Frédéric Subra ◽  
Christian Auclair
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Minor Groove ◽  
Moloney Murine Leukemia Virus ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Murine Leukemia ◽  
Dna Minor Groove Binder

Design, Synthesis, and Biological Activity of Hybrid Compounds between Uramustine and DNA Minor Groove Binder Distamycin A

2002 ◽  
Vol 45 (17) ◽  
pp. 3630-3638 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Romeo Romagnoli ◽  
Antonio Entrena Guadix ◽  
Maria Josè Pineda de las Infantas ◽  
Miguel Angel Gallo ◽  
...  
Keyword(s):  
Biological Activity ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Design Synthesis ◽  
Distamycin A ◽  
Dna Minor Groove ◽  
Hybrid Compounds ◽  
Dna Minor Groove Binder

scholarly journals Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding

2014 ◽  
Vol 10 (10) ◽  
pp. 2724-2734 ◽  
Author(s):  
Jie Zhou ◽  
Vu Le ◽  
Dimpy Kalia ◽  
Shizuka Nakayama ◽  
Clinton Mikek ◽  
...  
Keyword(s):  
Dissociation Constant ◽  
Dissociation Constants ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
G Quadruplex ◽  
Dna Minor Groove Binder

Diminazene or berenil is known to be an AT-rich DNA minor groove binder with micromolar dissociation constant. Here, we show that DMZ binds to G-quadruplexes withKdas low as 1 nM.

scholarly journals Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer

2012 ◽  
Vol 18 (19) ◽  
pp. 5399-5411 ◽  
Author(s):  
August Vidal ◽  
Clara Muñoz ◽  
María-José Guillén ◽  
Jemina Moretó ◽  
Sara Puertas ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder

Synthesis and Binding Studies of a New DNA Minor Groove Binder

1998 ◽  
Vol 51 (3) ◽  
pp. 243 ◽  
Author(s):  
Christopher I. Clark ◽  
David P. Kelly ◽  
Roger F. Martin ◽  
Jonathan M. White ◽  
Pavel Lobachevsky
Keyword(s):  
Minor Groove ◽  
Minor Groove Binder ◽  
Binding Studies ◽  
Dna Minor Groove ◽  
Indole Synthesis ◽  
Dna Minor Groove Binder

2-[2′-(4′′-Ethoxyphenyl)-1H-indol-6′-yl]-5-(4′′′-methylpiperazin-1′′′-yl)-1H-benzimidazole (1) has been synthesized from 2-(4′-ethoxyphenyl)-1H-indole-6-carbaldehyde (4b) and 4-(4′-methylpiperazin-1′-yl)benzene-1,2-diamine (3b). The aldehyde (4b) was prepared in five steps by using a modified Leimgruber–Batcho indole synthesis. Evaluation of (1) as a DNA ligand is described.

RNase Activity of a DNA Minor Groove Binder with a Minimalist Catalytic Motif from RNase A

2001 ◽  
Vol 281 (5) ◽  
pp. 1283-1290 ◽  
Author(s):  
Mark Helm ◽  
Mary L. Kopka ◽  
Sanjay K. Sharma ◽  
J.William Lown ◽  
Richard Giegé
Keyword(s):  
Minor Groove ◽  
Rnase A ◽  
Rnase Activity ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Catalytic Motif ◽  
Dna Minor Groove Binder

scholarly journals Diaminobenzene schiff base, a novel class of DNA minor groove binder

2012 ◽  
Vol 41 (2) ◽  
pp. 504-510 ◽  
Author(s):  
MUATH H. HELAL ◽  
ZENA A. AL-MUDARIS ◽  
MOHAMMED H. AL-DOUH ◽  
HASNAH OSMAN ◽  
HABIBAH A. WAHAB ◽  
...  
Keyword(s):  
Schiff Base ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
Dna Minor Groove ◽  
Dna Minor Groove Binder
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