scholarly journals A Case of Silicone and Sarcoid Granulomas in a Patient with “Highly Cohesive” Silicone Breast Implants: A Histopathologic and Laser Raman Microprobe Analysis

2021 ◽  
Vol 18 (9) ◽  
pp. 4526
Author(s):  
Todor I. Todorov ◽  
Erik de Bakker ◽  
Diane Smith ◽  
Lisette C. Langenberg ◽  
Linda A. Murakata ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Smooth Surface ◽  
Case Reports ◽  
Breast Implants ◽  
Textured Surface ◽  
Axillary Lymph ◽  
Silicone Breast Implants ◽  
Laser Raman ◽  
Single Lumen ◽  
Raman Microprobe

Foreign body giant cell (FBGC) reaction to silicone material in the lymph nodes of patients with silicone breast implants has been documented in the literature, with a number of case reports dating back to 1978. Many of these case reports describe histologic features of silicone lymphadenopathy in regional lymph nodes from patients with multiple sets of different types of implants, including single lumen smooth surface gel, single lumen textured surface gel, single lumen with polyethylene terephthalate patch, single lumen with polyurethane coating, and double lumen smooth surface. Only one other case report described a patient with highly-cohesive breast implants and silicone granulomas of the skin. In this article, we describe a patient with a clinical presentation of systemic sarcoidosis following highly cohesive breast implant placement. Histopathologic analysis and Confocal Laser Raman Microprobe (CLRM) examination were used to confirm the presence of silicone in the axillary lymph node and capsular tissues. This is the first report where chemical spectroscopic mapping has been used to establish and identify the coexistence of Schaumann bodies, consisting of calcium oxalate and calcium phosphate minerals, together with silicone implant material.

scholarly journals Multimodality Imaging-based Evaluation of Single-Lumen Silicone Breast Implants for Rupture

Radiographics ◽  
2017 ◽  
Vol 37 (2) ◽  
pp. 366-382 ◽  
Author(s):  
Stephen J. Seiler ◽  
Pooja B. Sharma ◽  
Jody C. Hayes ◽  
Ramapriya Ganti ◽  
Ann R. Mootz ◽  
...  
Keyword(s):  
Multimodality Imaging ◽  
Breast Implants ◽  
Silicone Breast Implants ◽  
Single Lumen

scholarly journals Diagnosis, investigation and management of breast implant illness

2021 ◽  
Vol 4 (1) ◽  
pp. 9-21
Author(s):  
Daniel WH Wong ◽  
Tai K Lam
Keyword(s):  
Case Reports ◽  
Breast Implant ◽  
Case Series ◽  
Breast Implants ◽  
Silicone Implants ◽  
Exact Nature ◽  
Cochrane Central Register ◽  
Case Control Studies ◽  
Silicone Breast Implants ◽  
Retrospective Cohort Studies

Introduction: An increasing pool of literature proposes a link between silicone implants and autoimmune-related symptoms known colloquially as breast implant illness (BII). We describe the history of BII, reported symptoms, risk factors and previously published diagnostic criteria to aid clinicians in the diagnosis, investigations and management of patients presenting with symptoms that they attribute to their silicone breast implants. Methods: A literature search was performed using MEDLINE®, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials (CENTRAL), the Database of Abstracts of Reviews of Effect (DARE) and PubMed in September 2018. The search terms ‘autoimmune inflammatory syndrome induced by adjuvants’, ‘breast implants’ and ‘silicone’ were used alone and in combination. Results: Thirty-four studies were reviewed including three case reports, 12 case series, 14 retrospective cohort studies, four case control studies and one prospective cohort study. Within this cohort, 18 studies were found regarding the explantation of implants relating to BII. Conclusion: Studies have demonstrated no association between silicone breast implants and any known autoimmune diseases, but there exists a pool of literature suggestive of a relatively undefined condition colloquially known as BII. Serological testing and imaging play an important role in the assessment of patients to exclude other pathology, but these tests remain non-diagnostic for BII. Although medical treatment has shown promise, there is no established treatment for patients. The surgical explantation of implants appears to have positive outcomes for patients; however, the exact nature of the surgery required to achieve this remains unclear.

Kikuchi-Fujimoto Disease-Like Inflammatory Reaction in a Silicone Breast Implant Seroma

2020 ◽  
Vol 64 (4) ◽  
pp. 386-389
Author(s):  
José A. Jiménez-Heffernan ◽  
Patricia Muñoz-Hernández ◽  
Carmen Bárcena
Keyword(s):  
Lymph Nodes ◽  
Inflammatory Reaction ◽  
Breast Implant ◽  
Breast Implants ◽  
Large Cell ◽  
Needle Aspiration ◽  
Cervical Lymph Nodes ◽  
Cytologic Examination ◽  
Silicone Breast Implants ◽  
Autoimmune Etiology

Introduction: Kikuchi-Fujimoto disease (KFD) may have an autoimmune etiology and some cases have been associated with silicone breast implants. Cytomorphologic features of the disease have been well characterized by fine-needle aspiration of lymph nodes. They are so specific as to permit a precise cytologic diagnosis. Cytologic features have not been reported in fluid specimens. Case: A 33-year-old female presented with a unilateral periprosthetic silicone breast seroma. The fluid was drained, and cytological analysis revealed numerous lymphocytes with no neutrophils, karyorrhectic nuclear debris, and peculiar histiocytes with eccentrically located nuclei showing a crescentic shape. Many of those histiocytes showed intracellular apoptotic debris. Conclusion: A Kikuchi disease-like inflammatory reaction is possible not only in axillary and cervical lymph nodes of patients with silicone breast implants but also in breast seromas. There is still not enough evidence to establish if there is an association between KFD and breast implants. A detailed cytologic examination of periprosthetic silicone breast seromas may help answer this question. In any case, pathologists must be aware of this possibility. Cytologic features are characteristic enough to permit differentiation from breast implant-associated anaplastic large-cell lymphoma.

scholarly journals Incidence of Internal Mammary Lymph Nodes with Silicone Breast Implants at MR Imaging after Oncoplastic Surgery

Radiology ◽  
2015 ◽  
Vol 277 (2) ◽  
pp. 381-387 ◽  
Author(s):  
Elizabeth J. Sutton ◽  
Elizabeth J. Watson ◽  
Girard Gibbons ◽  
Debra A. Goldman ◽  
Chaya S. Moskowitz ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Lymph Nodes ◽  
Breast Implants ◽  
Oncoplastic Surgery ◽  
Silicone Breast Implants ◽  
Internal Mammary Lymph Nodes ◽  
Internal Mammary

Invasive Mammary Carcinoma With Paneth Cell–Like Eosinophilic Cytoplasmic Granules: Is It an Entity?

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S47-S47
Author(s):  
Sakshi Sakshi ◽  
Yuri Persidsky ◽  
Kathleen Reilly ◽  
Suad Taraif
Keyword(s):  
Lymph Nodes ◽  
Ductal Carcinoma ◽  
Case Reports ◽  
Paneth Cell ◽  
Case Series ◽  
Surgical Excision ◽  
Resection Margins ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Cytoplasmic Granules

Abstract Breast carcinomas with Paneth cell–like eosinophilic cytoplasmic granules are rare and commonly reported in association with acinic cell carcinoma or microglandular adenosis. Paneth cell–like differentiation has been described outside the GI tract, including lung, liver, pancreas, lacrimal glands, and prostate. Very little is known about the significance of these granules and whether they represent a metaplastic or possibly a therapy-related change. There are only 45 reported cases involving the breast, mostly individual case reports or 2 to 3 case series. Although the clinical experience is limited, most of the reported cases seem clinically indolent. Here we present a 74-year-old female with a mammographically detected 1.1-cm left breast retroareolar mass for which she underwent a biopsy and subsequent lumpectomy with axillary dissection. Histology revealed an invasive ductal carcinoma, with Paneth cell–like eosinophilic PAS-positive cytoplasmic granules in the background of extensive ductal carcinoma in situ (DCIS). Similar granules were seen in some ducts involved by DCIS. Invasive carcinoma and DCIS were present throughout the 5.5-cm lumpectomy beyond the grossly measured 4.0-cm mass. There was extensive lymphovascular invasion and tumor was present at all the surgical resection margins. Twelve of the 13 axillary lymph nodes had macrometastases. The tumor was ER and PR positive and HER2 negative. Clinically, there were extensive bony metastases involving the skull, spine, sternum, iliac bones, and femur. There were also multiple lung nodules and mediastinal lymph nodes that were positive for metastasis on biopsy. The patient is still undergoing chemotherapy and radiotherapy 6 months following surgical excision. Our case demonstrates the heterogeneity of this entity as the clinical course in our patient has been very aggressive. A collaborative effort must be established to compile a larger case series to better our understanding of this increasingly reported histological observation and whether it represents a distinct entity.

scholarly journals An Unusual Case of Fever and Lymphadenopathy

2009 ◽  
Vol 8 (2) ◽  
pp. 73-74
Author(s):  
John Ho ◽  
Keyword(s):  
Unusual Case ◽  
Breast Implant ◽  
Breast Implants ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Medical Team ◽  
Radiological Imaging ◽  
Silicone Breast Implant ◽  
Silicone Breast Implants ◽  
Breast Implant Rupture

A 62 year old female presented to the acute medical team with headache, fevers and enlarged axillary lymph nodes. Initial biochemical, microbiological and immunological investigations were normal. However, radiological imaging revealed that her silicone breast implants had ruptured, which may have been responsible for her presentation. A brief overview of the clinical features and management of silicone breast implant rupture is provided.

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