scholarly journals Scoring Systems for Clinical Colon Capsule Endoscopy—All You Need to Know

2021 ◽  
Vol 10 (11) ◽  
pp. 2372
Author(s):  
Trevor Tabone ◽  
Anastasios Koulaouzidis ◽  
Pierre Ellul
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Colonic Polyps ◽  
Scoring Systems ◽  
Conventional Colonoscopy ◽  
Suitable Alternative ◽  
Specific Patient ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule ◽  
Event Rates

In the constantly developing era of minimal diagnostic invasiveness, the role of colon capsule endoscopy in colonic examination is being increasingly recognised, especially in the context of curtailed endoscopy services due to the COVID-19 pandemic. It is a safe diagnostic tool with low adverse event rates. As with other endoscopic modalities, various colon capsule endoscopy scores allow the standardisation of reporting and reproducibility. As bowel cleanliness affects CCE’s diagnostic yield, a few operator-dependent scores (Leighton–Rex and CC-CLEAR scores) and a computer-dependent score (CAC score) have been developed to grade bowel cleanliness objectively. CCE can be used to monitor IBD mucosal disease activity through the UCEIS and the panenteric CECDAIic score for UC and CD, respectively. CCE may also have a role in CRC screening, given similar sensitivity and specificity rates to conventional colonoscopy to detect colonic polyps ≥ 10 mm and CRC. Given CCE’s diagnostic yield and reproducible clinical scores with high inter-observer agreements, CCE is fast becoming a suitable alternative to conventional colonoscopy in specific patient populations.

scholarly journals Colon Capsule Endoscopy: Detection of Colonic Polyps Compared with Conventional Colonoscopy and Visualization of Extracolonic Pathologies

2014 ◽  
Vol 28 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Alexander F Hagel ◽  
Erwin Gäbele ◽  
Martin Raithel ◽  
Wolfgang H Hagel ◽  
Heinz Albrecht ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Bowel Preparation ◽  
Colonic Polyps ◽  
Conventional Colonoscopy ◽  
Colonic Disease ◽  
Polyp Detection ◽  
Colon Capsule Endoscopy ◽  
Extracolonic Findings ◽  
Colon Capsule ◽  
Technical Failures

BACKGROUND: Conventional colonoscopy (CC) is the gold standard for diagnostic examination of the colon. However, the overall acceptance of this procedure is low due to patient fears of complications or embarrassment. Colon capsule endoscopy (CCE) represents a minimally invasive, patient-friendly procedure that offers complete visualization of the entire intestine.OBJECTIVE: To assess the PillCam Colon 2 (Given Imaging Ltd, Israel) capsule with regard to feasibility, sensitivity and specificity for the detection of colonic pathologies and additional recorded extracolonic findings.METHODS: CCE was performed before CC in patients indicated for CC for known or suspected colonic disease. The results of both techniques were compared with regard to polyp detection. Additionally, bowel preparation and extracolonic pathologies were analyzed.RESULTS: Twenty-four patients (mean age 51.1 years) were included in the analysis. Visualization of the colon was complete in 23 CCs and 17 CCEs. No adverse events or major technical failures occurred. CC detected 47 polyps and CCE detected 43 polyps of any size (per-finding sensitivity 90.9%, specificity 67.6%). The accuracy of CCE in detecting polyp carriers was 81.5% (per-patient analysis). On average, the colon was adequately cleansed in 90.1% of patients. CCE identified esophageal, gastric and small bowel pathologies in seven (24%), nine (38%) and 14 (58%) patients, respectively.CONCLUSIONS: CCE proved to be technically feasible and safe. Acceptable sensitivity and moderate specificity levels in polyp detection were recorded. Bowel preparation was adequate in most patients. Because extracolonic pathologies were effectively visualized, new indications for the PillCam Colon 2 may be defined.

scholarly journals Capsule Endoscopy in Inflammatory Bowel Disease: When? To Whom?

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2240
Author(s):  
Soo-Young Na ◽  
Yun-Jeong Lim
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Postoperative Recurrence ◽  
Treat To Target ◽  
Diagnostic Modality ◽  
Colon Capsule Endoscopy ◽  
Bowel Diseases ◽  
Colon Capsule ◽  
The Cost

Capsule endoscopy (CE) has proven to be a valuable diagnostic modality for small bowel diseases over the past 20 years, particularly Crohn’s disease (CD), which can affect the entire gastrointestinal tract from the mouth to the anus. CE is not only used for the diagnosis of patients with suspected small bowel CD, but can also be used to assess disease activity, treat-to-target, and postoperative recurrence in patients with established small bowel CD. As CE can detect even mildly non-specific small bowel lesions, a high diagnostic yield is not necessarily indicative of high diagnostic accuracy. Moreover, the cost effectiveness of CE as a third diagnostic test employed usually after ileocolonoscopy and MR or CT enterography is an important consideration. Recently, new developments in colon capsule endoscopy (CCE) have increased the utility of CE in patients with ulcerative colitis (UC) and pan-enteric CD. Although deflation of the colon during the examination and the inability to evaluate dysplasia-associated lesion or mass results in an inherent risk of overestimation or underestimation, the convenience of CCE examination and the risk of flare-up after colonoscopy suggest that CCE could be used more actively in patients with UC.

scholarly journals Colon Capsule Endoscopy vs. CT Colonography Following Incomplete Colonoscopy: A Systematic Review with Meta-Analysis

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3367
Author(s):  
Ulrik Deding ◽  
Lasse Kaalby ◽  
Henrik Bøggild ◽  
Eva Plantener ◽  
Mie Kruse Wollesen ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Meta Analysis ◽  
Rate Sensitivity ◽  
Completion Rate ◽  
Polyp Detection ◽  
Proximal Point ◽  
Incomplete Colonoscopy ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

Following incomplete colonoscopy (IC) patients often undergo computed tomography colonography (CTC), but colon capsule endoscopy (CCE) may be an alternative. We compared the completion rate, sensitivity and diagnostic yield for polyp detection from CCE and CTC following IC. A systematic literature search resulted in twenty-six studies. Extracted data included inter alia, complete/incomplete investigations and polyp findings. Pooled estimates of completion rates of CCE and CTC and complete colonic view rates (CCE reaching the most proximal point of IC) of CCE were calculated. Per patient diagnostic yields of CCE and CTC were calculated stratified by polyp sizes. CCE completion rate and complete colonic view rate were 76% (CI 95% 68–84%) and 90% (CI 95% 83–95%). CTC completion rate was 98% (CI 95% 96–100%). Diagnostic yields of CTC and CCE were 10% (CI 95% 7–15%) and 37% (CI 95% 30–43%) for any size, 13% (CI 95% 9–18%) and 21% (CI 95% 12–32%) for >5-mm and 4% (CI 95% 2–7%) and 9% (CI 95% 3–17%) for >9-mm polyps. No study performed a reference standard follow-up after CCE/CTC in individuals without findings, rendering sensitivity calculations unfeasible. The increased diagnostic yield of CCE could outweigh its slightly lower complete colonic view rate compared to the superior CTC completion rate. Hence, CCE following IC appears feasible for an introduction to clinical practice. Therefore, randomized studies investigating CCE and/or CTC following incomplete colonoscopy with a golden standard reference for the entire population enabling estimates for sensitivity and specificity are needed.

False positive at colon capsule endoscopy or false negative at conventional colonoscopy?

Endoscopy ◽  
2010 ◽  
Vol 42 (05) ◽  
pp. 427-428 ◽  
Author(s):  
C. Spada ◽  
C. Hassan ◽  
M. Riccioni ◽  
G. Costamagna
Keyword(s):  
Capsule Endoscopy ◽  
False Positive ◽  
False Negative ◽  
Conventional Colonoscopy ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions

Digestion ◽  
2019 ◽  
Vol 101 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Ichiro Otani ◽  
Shiro Oka ◽  
Shinji Tanaka ◽  
Sumio Iio ◽  
Akiyoshi Tsuboi ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Diagnostic Yield ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

scholarly journals Colon Capsule Endoscopy compared to Conventional Colonoscopy under routine screening conditions

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Julia B Pilz ◽  
Susanne Portmann ◽  
Shajan Peter ◽  
Christoph Beglinger ◽  
Lukas Degen
Keyword(s):  
Capsule Endoscopy ◽  
Routine Screening ◽  
Conventional Colonoscopy ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule

scholarly journals Diagnostic yield of colon capsule endoscopy for Crohn’s disease lesions in the whole gastrointestinal tract

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Keisaku Yamada ◽  
Masanao Nakamura ◽  
Takeshi Yamamura ◽  
Keiko Maeda ◽  
Tsunaki Sawada ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Capsule Endoscopy ◽  
Large Bowel ◽  
Diagnostic Yield ◽  
Gi Tract ◽  
Colon Capsule Endoscopy ◽  
Colon Capsule ◽  
Bowel Segments

Abstract Background Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown. Aim To elucidate the diagnostic yield of PCCE-2 in patients with CD. Methods Patients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard. Results Of the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively. Conclusion PCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.

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