Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study

Background: 18F-fluorodeoxyglucose (18F-FDG) positron-emission-tomography (PET) allows detection of cerebral metabolic alterations in neurological diseases vs. normal aging. We assess age- and sex-related brain metabolic changes in healthy subjects, exploring impact of activity normalization methods. Methods: brain scans of Italian Association of Nuclear Medicine normative database (151 subjects, 67 Males, 84 Females, aged 20–84) were selected. Global mean, white matter, and pons activity were explored as normalization reference. We performed voxel-based and ROI analyses using SPM12 and IBM-SPSS software. Results: SPM proved a negative correlation between age and brain glucose metabolism involving frontal lobes, anterior-cingulate and insular cortices bilaterally. Narrower clusters were detected in lateral parietal lobes, precuneus, temporal pole and medial areas bilaterally. Normalizing on pons activity, we found a more significant negative correlation and no positive one. ROIs analysis confirmed SPM results. Moreover, a significant age × sex interaction effect was revealed, with worse metabolic reduction in posterior-cingulate cortices in females than males, especially in post-menopausal age. Conclusions: this study demonstrated an age-related metabolic reduction in frontal lobes and in some parieto-temporal areas more evident in females. Results suggested pons as the most appropriate normalization reference. Knowledge of age- and sex-related cerebral metabolic changes is critical to correctly interpreting brain 18F-FDG PET imaging.

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Cortico-Subcortical Metabolic Changes in Aging Brain: A 18F FDG PET/CT Study

International Journal of Nuclear Medicine Research ◽

10.15379/2408-9788.2014.01.01.4 ◽

2014 ◽

Vol 1 (1) ◽

pp. 17-23 ◽

Cited By ~ 1

Author(s):

Agostino Chiaravalloti ◽

◽

Paolo Abbatiello ◽

Ferdinando Calabria ◽

Barbara Palumbo ◽

...

Keyword(s):

Fdg Pet ◽

Metabolic Changes ◽

Aging Brain ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Metabolic Changes of Brain Developmental Venous Anomalies on 18F-FDG-PET

Academic Radiology ◽

10.1016/j.acra.2018.05.021 ◽

2019 ◽

Vol 26 (4) ◽

pp. 443-449 ◽

Cited By ~ 1

Author(s):

Jillian W. Lazor ◽

J. Eric Schmitt ◽

Laurie A. Loevner ◽

S. Ali Nabavizadeh

Keyword(s):

Fdg Pet ◽

Metabolic Changes ◽

Venous Anomalies ◽

Developmental Venous Anomalies ◽

18F Fdg

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Prospective Evaluation of Physiologic Uptake Detected with True Whole-Body 18F-FDG PET/CT in Healthy Subjects

Journal of Nuclear Medicine Technology ◽

10.2967/jnmt.108.055004 ◽

2009 ◽

Vol 37 (1) ◽

pp. 31-37 ◽

Cited By ~ 13

Author(s):

M. F. Reinking ◽

M. M. Osman

Keyword(s):

Fdg Pet ◽

Healthy Subjects ◽

Whole Body ◽

Prospective Evaluation ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Statistical parametric mapping and [18F]FDG PET for the evaluation of acute cerebral metabolic changes after a single dose of haloperidol

Psychiatry Research Neuroimaging ◽

10.1016/s0925-4927(97)81568-5 ◽

1997 ◽

Vol 68 (2-3) ◽

pp. 174

Author(s):

R. Schloesser ◽

E.J. Bartlett ◽

P. Simkowitz ◽

H. Rusinek ◽

S.A. Berry ◽

...

Keyword(s):

Single Dose ◽

Fdg Pet ◽

Statistical Parametric Mapping ◽

Metabolic Changes ◽

Parametric Mapping ◽

18F Fdg

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P4-112: COMBINED 18F-FDG-PET AND 1H-MRS EVALUATION OF CEREBRAL METABOLIC CHANGES IN MILD COGNITIVE IMPAIRMENT

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.05.1628 ◽

2014 ◽

Vol 10 ◽

pp. P825-P825

Author(s):

Vladimir Lobzin ◽

Sergey Vorobyev ◽

Ivan Lupanov ◽

Andrey Emelin ◽

Vladimir Fokin ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Fdg Pet ◽

Metabolic Changes ◽

1H Mrs ◽

18F Fdg

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GlucoCEST MRI for the early evaluation response to chemotherapeutic and metabolic treatments in a murine triple negative breast cancer: a comparison with 18F-FDG-PET.

10.1101/2021.03.16.432430 ◽

2021 ◽

Author(s):

Martina Capozza ◽

Annasofia Antonia Anemone ◽

Chetan Dhakan ◽

Melania Della Peruta ◽

Martina Bracesco ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Metabolic Activity ◽

Fdg Pet ◽

Therapeutic Response ◽

Triple Negative ◽

Metabolic Response ◽

Metabolic Changes ◽

Pet Ct ◽

18F Fdg

Triple-negative breast cancer (TNBC) patients have usually poor outcome after chemotherapy and early prediction of therapeutic response would be helpful. 18F-FDG-PET/CT acquisitions are often carried out to monitor variation in metabolic activity associated to response to the therapy, despite moderate accuracy and radiation exposure limit its application. The glucoCEST technique relies on the use of unlabelled D-glucose to assess glucose uptake with conventional MRI scanners and is currently under active investigations at clinical level. This work aims at validating the potential of MRI glucoCEST in monitoring early therapeutic responses in a TNBC tumor murine model. Methods: Breast tumor (4T1) bearing mice were treated with doxorubicin or dichloroacetate for one week. PET/CT with 18F-FDG and MRI-glucoCEST were performed at baseline and after 3 cycles of treatment. Metabolic changes measured with 18F-FDG-PET and glucoCEST were compared and evaluated with changes in tumor volumes. Results: Doxorubicin treated mice showed a significant decrease in tumor growth when compared to the control group. GlucoCEST imaging provided early metabolic response after three cycles of treatment, conversely, no variations were detect by in 18F-FDG uptake. Dichloroacetate treated mice did not show any decrease either in tumor volume or in tumor metabolic activity as assessed by both glucoCEST and 18F-FDG-PET. Conclusions: Early metabolic changes during doxorubicin treatment can be predicted by glucoCEST imaging that appears more sensitive than 18F-FDG-PET in reporting on early therapeutic response. These findings support the view that glucoCEST may be a sensitive technique for monitoring metabolic response, but future studies are needed to explore the accuracy of this approach in other tumor types and treatments.

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PET Hypometabolism of the Prefrontal-Cingulate Cortices in Internet Gaming Disorder

Frontiers in Psychiatry ◽

10.3389/fpsyt.2020.566518 ◽

2021 ◽

Vol 11 ◽

Author(s):

Sun Ki Kim ◽

Hyeonseok Jeong ◽

Jooyeon Jamie Im ◽

Sang Hoon Lee ◽

Yong-An Chung

Keyword(s):

Anterior Cingulate Cortex ◽

Fdg Pet ◽

Internet Gaming Disorder ◽

Cingulate Cortex ◽

Anterior Cingulate ◽

Self Report ◽

Control Group ◽

Gaming Disorder ◽

Internet Gaming ◽

18F Fdg

Recently, excessive and uncontrolled use of online games has been recognized as a public concern. Although previous neuroimaging studies have reported structural and functional brain deficits in Internet gaming disorder (IGD), very few studies have investigated the regional cerebral metabolic rate of glucose (rCMRglu). This study investigated the differences in rCMRglu between individuals with IGD and healthy controls using 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET). A total of 23 adults with IGD and 23 controls underwent brain 18F-FDG PET scans and completed self-report questionnaires. A whole-brain voxel-wise analysis of rCMRglu was conducted and associations between rCMRglu and severity of IGD were assessed. The IGD group showed higher impulsivity (p = 0.04) and lower self-control (p = 0.002) than the control group. In addition, the IGD group had lower FDG uptake in the left medial orbitofrontal gyrus, left middle cingulate cortex, left superior frontal gyrus, and right anterior cingulate cortex (p < 0.001). A significant negative association was found between the rCMRglu in the right anterior cingulate cortex and the number of fulfilled diagnostic criteria for IGD (β = −0.50, p = 0.02). Our results suggest that IGD may be associated with deficits of glucose metabolism in the prefrontal-cingulate cortices.

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