scholarly journals 8-Isoprostanes and Asymmetric Dimethylarginine as Predictors of Mortality in Patients Following Coronary Bypass Surgery: A Long-Term Follow-Up Study

2022 ◽  
Vol 11 (1) ◽  
pp. 246
Author(s):  
Aleksandra Gołąb ◽  
Dariusz Plicner ◽  
Anna Rzucidło-Hymczak ◽  
Lidia Tomkiewicz-Pająk ◽  
Bogusław Gawęda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Mortality ◽  
Bypass Surgery ◽  
Asymmetric Dimethylarginine ◽  
Prostaglandin F2α ◽  
Cardiovascular Death ◽  
Long Term Follow Up ◽  
Nitric Oxide Bioavailability

Background: We previously demonstrated that enhanced oxidative stress and reduced nitric oxide bioavailability are associated with unfavorable outcomes early after coronary artery bypass grafting. It is not known whether these processes may impact long-term results. We sought to assess whether during long-term follow-up, markers of oxidative stress and nitric oxide bioavailability may predict cardiovascular mortality following bypass surgery. Methods: We studied 152 consecutive patients (118 men, age 65.2 ± 8.3 years) who underwent elective, primary, isolated on-pump bypass surgery. We measured plasma 8-iso-prostaglandin F2α and asymmetric dimethylarginine before surgery and twice after surgery (18–36 h and 5–7 days). We assessed all-cause and cardiovascular death in relation to these two biomarkers during a mean follow-up time of 11.7 years. Results: The overall mortality was 44.7% (4.7 per 100 patient-years) and cardiovascular mortality was 21.0% (2.2 per 100 patient-years). Baseline 8-iso-prostaglandin F2α was associated with cardiovascular mortality (HR 1 pg/mL 1.010, 95% CI 1.001–1.021, p = 0.036) with the optimal cut-off ≤ 364 pg/mL for higher survival rate (HR 0.460, 95% CI 0.224–0.942, p = 0.030). Asymmetric dimethylarginine > 1.01 μmol/L measured 18–36 h after surgery also predicted cardiovascular death (HR 2.467, 95% CI 1.140–5.340, p = 0.020). Additionally, elevated 8-iso-prostaglandin F2α measured at the same time point associated with all-cause mortality (HR 1 pg/mL 1.007, 95% CI 1.000–1.014, p = 0.048). Conclusions: Our findings indicate that in advanced coronary disease, increased oxidative stress, reflected by 8-iso-prostaglandin F2α before bypass surgery and enhanced asymmetric dimethylarginine accumulation just after the surgery are associated with cardiovascular death during long-term follow-up

Long-term-follow-up of patients with gastric bypass surgery secondary to craniopharyngioma associated hypothalamic obesity

2020 ◽  
Author(s):  
Hannes Beiglböck ◽  
Paul Fellinger ◽  
Tamara Ranzenberger-Haider ◽  
Greisa Vila ◽  
Anton Luger ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Hypothalamic Obesity ◽  
Long Term Follow Up

The Long-Term Follow-Up of Patients Undergoing Saphenous Vein Bypass Surgery

Circulation ◽  
1974 ◽  
Vol 49 (1) ◽  
pp. 77-85 ◽  
Author(s):  
DAVID S. CANNOM ◽  
D. CRAIG MILLER ◽  
NORMAN E. SHUMWAY ◽  
THOMAS J. FOGARTY ◽  
PAT O. DAILY ◽  
...  
Keyword(s):  
Saphenous Vein ◽  
Bypass Surgery ◽  
Saphenous Vein Bypass ◽  
Long Term Follow Up ◽  
Vein Bypass

scholarly journals Pitfalls with long-term follow-up of postoperative choledochal cysts: significance of identifying patients with abandoned bypass surgery (cysto-duodenostomy)

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e466
Author(s):  
Y. Fujimoto ◽  
T. Takayanagi ◽  
S. Horitani ◽  
T. Kobayashi ◽  
D. Konishi ◽  
...  
Keyword(s):  
Bypass Surgery ◽  
Choledochal Cysts ◽  
Long Term Follow Up

Long-term follow-up of survivors of prehospital sudden cardiac death treated with coronary bypass surgery

1985 ◽  
Vol 110 (6) ◽  
pp. 1139-1145 ◽  
Author(s):  
Donald D. Tresch ◽  
Jule N. Wetherbee ◽  
Ronald Siegel ◽  
Paul J. Troup ◽  
Michael H. Keelan ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Long Term Follow Up

Donor Selection in Flow Replacement Bypass Surgery for Cerebral Aneurysms: Quantitative Analysis of Long-term Native Donor Flow Sufficiency

Neurosurgery ◽  
2015 ◽  
Vol 78 (3) ◽  
pp. 332-342 ◽  
Author(s):  
Oriela Rustemi ◽  
Sepideh Amin-Hanjani ◽  
Sophia F. Shakur ◽  
Xinjian Du ◽  
Fady T. Charbel
Keyword(s):  
Bypass Surgery ◽  
Superficial Temporal Artery ◽  
Cerebral Aneurysms ◽  
Temporal Artery ◽  
Donor Selection ◽  
Flow Data ◽  
Bypass Flow ◽  
Long Term Follow Up

Abstract BACKGROUND: Graft selection in extracranial-intracranial bypass surgery for cerebral aneurysms has traditionally been based on clinical impression and operator preference. However, decision making can be optimized with a donor selection algorithm based on intraoperative flow data. OBJECTIVE: To present long-term follow-up and quantitative assessment of flow sufficiency for native donors selected in this manner. METHODS: Patients with bypass for anterior circulation intracranial aneurysms using only a native donor (superficial temporal artery) selected on the basis of an intraoperative flow algorithm over a 10-year period were retrospectively studied. Intracranial hemispheric and bypass flows were assessed preoperatively and postoperatively when available with quantitative magnetic resonance angiography. RESULTS: Twenty-two patients with flow data were included (median aneurysm size, 22 mm). The intraoperative flow offer (cut flow) of the superficial temporal artery was sufficient in these cases relative to the flow demand in the sacrificed vessel (59 vs 28 mL/min) to warrant its use. Bypass flow averaged 81 mL/min postoperatively (n = 19). Bypass flows were highest in the immediate postoperative period but remained stable between the intermediate and final follow-up (40 vs 52 mL/min; P = .39; n = 8). Mean ipsilateral hemisphere flows were maintained after bypass (299 vs 335 mL/min; P = .42; n = 7), and remained stable over intermediate and long-term follow-up. Ipsilateral hemispheric flows remained similar to contralateral flows at all time points. CONCLUSION: Despite a relative reduction in bypass flow over time, hemispheric flows were maintained, indicating that simple native donors can carry sufficient flow for territory demand long term when an intraoperative flow-based algorithm is used for donor selection.

scholarly journals Malondialdehyde can predict survival in hemodialysis patients

2016 ◽  
Vol 89 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Crina Claudia Rusu ◽  
Simona Racasan ◽  
Ina Maria Kacso ◽  
Diana Moldovan ◽  
Alina Potra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cox Model ◽  
Statistical Significance ◽  
Morbidity And Mortality ◽  
Protein Carbonyls ◽  
Cross Sectional ◽  
Long Term Follow Up ◽  
Cv Disease

Background and aims. Cardiovascular (CV) disease is the leading cause of morbidity and mortality in hemodialysis (HD) patients. Kidney disease is associated with increased oxidative stress (OS), a nontraditional CV risk factor. Few studies evaluate the effect of OS markers on CV events (CVE) and survival in HD patients. The aim of this study is to examine potential determinants of OS markers and their predictive role on survival and CV morbidity and mortality in HD patients during a long-term follow-up (108 months).  Methods. We conducted an analytical cross-sectional prospective observational study, carried on a cohort of randomly selected HD patients. We registered in 44 HD patients baseline characteristics, OS markers, mortality and CVE over a period of 108 months and we used statistical analysis (descriptive, Kaplan-Meier, univariate and multivariate Cox model) for interpretation.Results. Bound malondialdehyde (bMDA) was positively correlated with serum calcium, protein carbonyls (PC) were inversely correlated with diastolic blood pressure (DBP) and directly correlated with ferritin, NOx was directly correlated with ceruloplasmin) and serum albumin. Of the measured OS markers only bMDA was related to survival (HR=3.29 95% CI (1.28-8.44), p=0.01), and approached statistical significance in the effect on CV mortality (HR=2.85 95% CI (0.88-9.22), p=0.07). None of the measured OS markers was associated with CVE.Conclusions. bMDA has a strong predictive value on survival in HD patients in a long-term follow-up (9 years). Its value is correlated with CV mortality but is not a predictor of CV events. Regular assessment of MDA in HD patients and the development of strategies aimed at reducing oxidative stress in these patients might be beneficial.

Reoperation After Coronary Bypass Surgery: Technical Aspects and Long-term Follow-up

1987 ◽  
pp. 248-254
Author(s):  
R. A. E. Dion ◽  
G. Jambroes ◽  
B. Jambroes ◽  
B. J. Amsel ◽  
R. van Haase ◽  
...  
Keyword(s):  
Bypass Surgery ◽  
Coronary Bypass ◽  
Coronary Bypass Surgery ◽  
Technical Aspects ◽  
Long Term Follow Up
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