scholarly journals Fungal Endophthalmitis: A Comprehensive Review

2021 ◽  
Vol 7 (11) ◽  
pp. 996
Author(s):  
Abid A. Haseeb ◽  
Abdelrahman M. Elhusseiny ◽  
Mohammad Z. Siddiqui ◽  
Kinza T. Ahmad ◽  
Ahmed B. Sallam

Endophthalmitis is a serious ophthalmologic condition involving purulent inflammation of the intraocular spaces. The underlying etiology of infectious endophthalmitis is typically bacterial or fungal. The mechanism of entry into the eye is either exogenous, involving seeding of an infectious source from outside the eye (e.g., trauma or surgical complications), or endogenous, involving transit of an infectious source to the eye via the bloodstream. The most common organism for fungal endophthalmitis is Candida albicans. The most common clinical manifestation of fungal endophthalmitis is vision loss, but other signs of inflammation and infection are frequently present. Fungal endophthalmitis is a clinical diagnosis, which can be supported by vitreous, aqueous, or blood cultures. Treatment involves systemic and intravitreal antifungal medications as well as possible pars plana vitrectomy. In this review, we examine these essential elements of understanding fungal endophthalmitis as a clinically relevant entity, which threatens patients’ vision.

Author(s):  
Tomasz K. Wilczyński ◽  
Alfred Niewiem ◽  
Rafał Leszczyński ◽  
Katarzyna Michalska-Małecka

A 36-year-old patient presented to the hospital with recurrent dislocation of the intraocular lens (IOL). The patient with the diagnosis of familial ectopia lentis was first operated on for crystalline lens subluxation in the left eye in 2007 and in the right eye in 2009. In both eyes, lens extraction with anterior vitrectomy and transscleral fixation of a rigid IOL was performed. In 2011, the IOL in the right eye luxated into the vitreous cavity due to ocular trauma. The patient underwent a pars plana vitrectomy with the IOL resuturation to the sclera. Seven years later, a spontaneous vision loss in the right eye was caused by a retinal detachment. The pars plana vitrectomy with silicone oil tamponade and a consequential oil removal three months later were performed in 2018. The follow-up examination revealed recurrent IOL dislocation in the same eye. Due to a history of previous suture-related complications a decision was made to remove the subluxated rigid polymethyl-methacrylate (PMMA) IOL and fixate to sclera a sutureless SOLEKO FIL SSF Carlevale lens. The purpose of this report is to present a single case of a 36-year-old patient who was presented to the hospital with recurrent dislocation of the intraocular lens. In a three-month follow-up period, a good anatomical and functional outcome was finally obtained with transscleral sutureless intraocular lens. This lens is an option worth considering especially in a young patient with a long life expectancy and physically active.


2017 ◽  
Vol 11 (2) ◽  
pp. 171-174 ◽  
Author(s):  
Hammouda H. Ghoraba ◽  
Amin F. Ellakwa ◽  
Emad M. Elgemai ◽  
Hosam O. Mansour ◽  
Mohammed A. Heikal

Retina ◽  
2017 ◽  
Vol 37 (4) ◽  
pp. 651-656 ◽  
Author(s):  
Benjamin J. Thomas ◽  
Neesurg Mehta ◽  
Yoshihiro Yonekawa ◽  
Jayanth Sridhar ◽  
Ajay E. Kuriyan ◽  
...  

2020 ◽  
Vol 29 (1) ◽  
pp. 96-102
Author(s):  
İrem GÜNEŞ ◽  
Günhal ŞATIRTAV ◽  
Banu TURGUT ÖZTÜRK ◽  
Muhammet Utku UZDİL ◽  
Hürkan KERİMOĞLU

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Hassan Elkayal ◽  
Ahmed M. Bedda ◽  
Hesham El-Goweini ◽  
Ahmed A. Souka ◽  
Amir Ramadan Gomaa

Purpose. To compare the efficacy of pars plana vitrectomy (PPV) versus intravitreal injection (IVI) of ranibizumab (RBZ) in the treatment of diabetic macular edema (DME) associated with vitreomacular interface abnormalities (VMIA). Methods. The records of patients presenting with DME and VMIA throughout 2016 to 2018 were retrospectively analyzed. The patients were divided into 2 groups: group I received IVIs of RBZ and group II underwent PPV with internal limiting membrane peeling. The main outcome measures were the change in the LogMAR corrected distance visual acuity (CDVA) and central subfield thickness (CSFT) on optical coherence tomography over 6 months. Results. At 6 months, mean CDVA improved by 0.22 ± 0.21 in group I patients p < 0.001 , while in group II, it improved only by 0.09 ± 0.22 p < 0.115 . Fifty-five percent of group I and 60% of group II patients had stable CDVA (within 2 lines from baseline) at 6 months. Significant improvement in vision (gain of 2 or more lines) was seen in 45% and 30%, respectively. Worsening of vision (loss of 2 or more lines) was seen only in 2 patients in group II, but none in group I. The mean CSFT improved significantly in both groups (by 162 µ and 216 µ, respectively; p < 0.001 ). The mean CSFT at 6 months was similar in both groups (354 µ and 311 µ, respectively; p = 0.172 ). Conclusions. Both treatments resulted in anatomical improvement of DME with concurrent VMIA. Visual improvement was more pronounced in the IVI group, although this may have been affected by other confounding factors.


2020 ◽  
pp. 112067212096058
Author(s):  
Miriam Rahhal-Ortuño ◽  
Patricia Udaondo-Mirete ◽  
Alex Samir Fernández-Santodomingo ◽  
Manuel Díaz-Llopis

A 64-year-old Caucasian woman was referred to our hospital after referring vision loss; she had been previously diagnosed with systemic diffuse large B-cell lymphoma. Retinal and optic nerve involvement were found in her right eye, and iris and vitreous involvement were found in her left eye. Vitreoretinal lymphomas (VRL) are rare in medical literature, hence there is a lack of standardised studies regarding therapeutic options in these patients. In our patient, we decided to add intravitreal injections of rituximab and methotrexate to systemic chemotherapy, and to perform pars plana vitrectomy.


2012 ◽  
Vol 57 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Nieraj Jain ◽  
Brooks W. McCuen ◽  
Prithvi Mruthyunjaya

2021 ◽  
Vol 14 (4) ◽  
pp. e240425
Author(s):  
Alexander B Crane ◽  
Monica C Abreu Diaz ◽  
Yi Jiang ◽  
Kathleen Mangunay Pergament

A 35-year-old Hispanic man presented with fever, chills, dysuria, diarrhoea, scleral icterus, tachycardia and tachypnea. He was found to be COVID-19 positive, CT of the pelvis revealed prostatic abscess, and urine culture grew Klebsiella pneumoniae. Additionally, he was found to have diabetes and cirrhosis. During treatment, the patient developed vision loss, and was diagnosed with endogenous Klebsiella endophthalmitis. The patient was treated with intravenous antibiotics, pars plana vitrectomy, intravitreal antibiotics and cystoscopy/suprapubic catheter placement. On follow-up, the patient has had the suprapubic catheter removed, and successfully passed a voiding trial, but suffers permanent vision loss in both eyes.


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