scholarly journals Electrocatalytic Behavior and Determination of Amitriptyline Drug with MWCNT@Celllulose Composite Modified Glassy Carbon Electrode

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1708 ◽  
Author(s):  
Aftab Aslam Parwaz Khan
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Oxidation Potential ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Multiwalled Carbon ◽  
Peak Current ◽  
Thermal Investigations

A novel nanocomposite of cellulose based on multiwalled carbon nanotube (MWCNT) was synthesized by a simple solution mixing–evaporation method. The morphology, thermal investigations, electrocatalytic oxidation of amitriptyline were analyzed at multi-walled carbon/cellulose nanocomposite in detail. The amitriptyline (AMT) drug was electrochemically studied in a phosphate buffer at different pH using the MWCNT/cellulose modified glassy carbon electrode (GCE). As per the linear relationship among AMT along with peak current, differential pulse voltammetry technique has been established for their quantitative pharmaceutical’s determination. The oxidation potential shifted negatively compared to GCE, showing that the MWCNT/cellulose modified electrode had an excellent catalytic activity for the AMT oxidation. The anodic peak current varied linear response with AMT’s concentration in the range of 0.5 to 20.0 μM with a LOD of 0.0845 μM and LOQ of 0.282 μM, respectively. The proposed method was effectively put on the determination of AMT in pharmaceutical and urine samples. This novel methodology is presented here as an example of a complete development methodology for the determination of amitriptyline drug and sensor for use in healthcare fields.

Electrocatalytic Response and Determination of Noradrenaline in the Presence of L-Ascorbic and Uric Acids with Poly(Eriochrome Black T)-Modified Electrode

2007 ◽  
Vol 72 (9) ◽  
pp. 1177-1188 ◽  
Author(s):  
Xinhua Lin ◽  
Wei Li ◽  
Hong Yao ◽  
Yuanyuan Sun ◽  
Liying Huang ◽  
...  
Keyword(s):  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Dynamic Range ◽  
Differential Pulse ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Eriochrome Black T ◽  
Wide Linear Dynamic Range

A poly(Eriochrome Black T) chemically modified glassy carbon electrode modified with Eriochrome Black T was prepared by cyclic voltammetry. The modified electrode showed an excellent electrocatalytic activity in oxidation of noradrenaline (NA) and could separate its electrochemical responses from those of L-ascorbic acid (AA) and uric acid (UA). Differences of the oxidation peak potentials for NA-AA and UA-NA were about 150 mV. The responses to NA, AA and UA of the modified electrode are relatively independent. Using differential pulse voltammetry, the peak currents of NA at modified glassy carbon electrode increased linearly with the concentration of NA from 0.5 to 100 μmol l-1. The detection limit was 0.2 μmol l-1. With the modified electrode, UA could be selectively determined in the presence of AA. The method showing a wide linear dynamic range and excellent sensitivity was successfully applied to the determination of NA in pharmaceutical injections and various samples.

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