Augmentation Stability of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with L-shaped Porcine-Derived Block Bone Substitute

Block bone substitutes have better augmentation stability for guided bone regeneration (GBR) than particulate bone substitutes. This study sought to determine whether GBR with an L-shaped porcine block bone (DPBM-C) differs from GBR with an L-shaped bovine block bone (DBBM-C) based on clinical, radiographic, and volumetric outcomes for peri-implant dehiscence defects. A total of 42 peri-implant defects were grafted with 20 L-shaped DPBM-C and 22 DBBM-C groups. The horizontal and vertical thicknesses of the augmented hard tissue were measured using sagittal cone-beam computed tomography, and the volumetric tissue change was evaluated by stereolithography image superimposition. Postoperative discomfort, early wound healing outcomes, and implant stability were also assessed. Among the clinical (subjective pain and swelling, wound dehiscence, membrane exposure, and periotest values), radiographic (changes in horizontal and vertical hard tissue thickness), and volumetric parameters of the L-shaped DPBM-C and DBBM-C groups during the healing period, only the periotest values showed a statistically significant difference (0.67 ± 1.19, p = 0.042). Within the limitations of this study, an L-shaped DPBM-C is not inferior to an L-shaped DBBM-C based on their clinical, radiographic, and volumetric outcomes for GBR of peri-implant dehiscence defects.

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Hard tissue changes after guided bone regeneration of peri‐implant defects comparing block versus particulate bone substitutes: 6‐month results of a randomized controlled clinical trial

Clinical Oral Implants Research ◽

10.1111/clr.13515 ◽

2019 ◽

Vol 30 (10) ◽

pp. 1016-1026 ◽

Cited By ~ 8

Author(s):

Goran I. Benic ◽

Barbara M. Eisner ◽

Ronald E. Jung ◽

Tobias Basler ◽

David Schneider ◽

...

Keyword(s):

Clinical Trial ◽

Bone Regeneration ◽

Bone Substitutes ◽

Guided Bone Regeneration ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Hard Tissue ◽

Randomized Controlled ◽

Tissue Changes

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Augmentation stability and early wound healing outcomes of guided bone regeneration in peri‐implant dehiscence defects with L‐ and I‐shaped soft block bone substitutes: A clinical and radiographic study

Clinical Oral Implants Research ◽

10.1111/clr.13830 ◽

2021 ◽

Author(s):

Eun‐Hee Jung ◽

Seong‐Nyum Jeong ◽

Jae‐Hong Lee

Keyword(s):

Wound Healing ◽

Bone Regeneration ◽

Bone Substitutes ◽

Guided Bone Regeneration ◽

Radiographic Study ◽

Early Wound

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RADIOGRAPHIC CHANGES IN THE BONE GRAFTS DURING GUIDED BONE REGENERATION WITH THE USE OF TITANIUM MESH ON CLASSICAL AND AUTHORS' OWN METHODS FOR THE MUCOSAL FLAPS DETACHMENT

World of Medicine and Biology ◽

10.26724/2079-8334-2020-1-71-63-68 ◽

2020 ◽

Vol 16 (71) ◽

pp. 063

Author(s):

D. V. Kaplun ◽

D. S. Avetikov ◽

O. S. Ivanytska ◽

I. V. Boiko ◽

V. M. Havryliev

Keyword(s):

Bone Regeneration ◽

Bone Grafts ◽

Guided Bone Regeneration ◽

Titanium Mesh ◽

Radiographic Changes

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Clinical and histological sequelae of surgical complications in horizontal guided bone regeneration: a systematic review and proposal for management

International Journal of Implant Dentistry ◽

10.1186/s40729-020-00274-y ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

John Rong Hao Tay ◽

Xiaotong Jacinta Lu ◽

Wei Ming Clement Lai ◽

Jia-Hui Fu

Keyword(s):

Bone Regeneration ◽

Surgical Complications ◽

Wound Dehiscence ◽

Guided Bone Regeneration ◽

Cochrane Central Register ◽

Weighted Mean ◽

Recipient Site ◽

Barrier Membrane ◽

Incidence Proportion ◽

Level Analysis

AbstractIt is not uncommon to encounter post-surgical complications after horizontal guided bone regeneration (GBR). The primary aim of this review was to evaluate the incidence and types of complications that occur after horizontal GBR and propose management strategies to deal with these clinical situations. A secondary aim was to conduct a histomorphometric review of the wound healing process at sites that experienced post-surgical complications after GBR. A keyword search of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for studies published in English from January 2015 to January 2020 was conducted for the primary aim and 23 studies were selected. A second search addressing the secondary aim was conducted, and five studies were included. Site-level analysis showed that the weighted mean incidence proportion of minor wound dehiscence and minor infections occurring at the augmented site was 9.9% [95% CI 6.4, 13.9, P < 0.01] and 1.5% [95% CI 0.4, 3.1, P = 0.21) respectively. Patient-level analysis showed minor and major complications occurring at a weighted mean incidence proportion of 16.1% [95% CI 11.9, 20.8, P = 0.01] and 1.6% [95% CI 0.0, 4.7, P < 0.01] respectively, while neurosensory alterations at the donor site was 7.0% [95% CI 1.3, 15.5, P < 0.01]. Subgroup analysis also revealed that the use of block grafts increased the incidence proportion of minor post-surgical complications, whereas a staged GBR procedure increased the incidence proportion of both minor and major post-surgical complications. Although exposure of the barrier membrane is often associated with less bone regeneration and graft resorption, the type of membrane used (resorbable or non-resorbable) had no statistically significant influence on any post-surgical complication. Histologically, a layer of fibrous connective tissue instead of bone is commonly observed at the interface between the native bone at the recipient site and the regenerated bone in cases with membrane exposure after GBR procedure. Minor wound dehiscence was the highest incidence proportion of post-surgical complications. Methods ranging from daily application of antiseptics, use of systemic antimicrobials, regular reviews, and total removal of the non-integrated biomaterials are commonly prescribed to manage these post-surgical complications in attempt to minimise the loss of tissue at the surgical site.

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Long-Term Follow-Up on Soft and Hard Tissue Levels Following Guided Bone Regeneration Treatment in Combination with a Xenogeneic Filling Material: A 5-Year Prospective Clinical Study

Clinical Implant Dentistry and Related Research ◽

10.1111/j.1708-8208.2009.00163.x ◽

2010 ◽

Vol 12 (4) ◽

pp. 263-270 ◽

Cited By ~ 27

Author(s):

C. Dahlin ◽

M. Simion ◽

N. Hatano

Keyword(s):

Clinical Study ◽

Bone Regeneration ◽

Guided Bone Regeneration ◽

Prospective Clinical Study ◽

Filling Material ◽

Hard Tissue ◽

Tissue Levels ◽

Long Term Follow Up

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Guided bone regeneration using resorbable membrane and different bone substitutes: Early histological and molecular events

Acta Biomaterialia ◽

10.1016/j.actbio.2015.10.005 ◽

2016 ◽

Vol 29 ◽

pp. 409-423 ◽

Cited By ~ 49

Author(s):

Ibrahim Elgali ◽

Alberto Turri ◽

Wei Xia ◽

Birgitta Norlindh ◽

Anna Johansson ◽

...

Keyword(s):

Bone Regeneration ◽

Bone Substitutes ◽

Guided Bone Regeneration ◽

Molecular Events

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Guided bone regeneration with particulate vs. block xenogenic bone substitutes: a pilot cone beam computed tomographic investigation

Clinical Oral Implants Research ◽

10.1111/clr.13011 ◽

2017 ◽

Vol 28 (11) ◽

pp. e262-e270 ◽

Cited By ~ 12

Author(s):

Goran I. Benic ◽

Daniel S. Thoma ◽

Ronald E. Jung ◽

Ignacio Sanz-Martin ◽

Silvan Unger ◽

...

Keyword(s):

Bone Regeneration ◽

Bone Substitutes ◽

Guided Bone Regeneration ◽

Cone Beam ◽

Computed Tomographic ◽

Xenogenic Bone

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Effects of Platelet-Rich Fibrin on Hard Tissue Healing: A Histomorphometric Crossover Trial in Sheep

Materials ◽

10.3390/ma13071695 ◽

2020 ◽

Vol 13 (7) ◽

pp. 1695

Author(s):

Esra Ondur ◽

Nilufer Bolukbasi Balcioglu ◽

Merva Soluk Tekkesin ◽

Ozlem Guzel ◽

Selim Ersanli

Keyword(s):

Bone Regeneration ◽

Bone Defects ◽

Collagen Membrane ◽

Bovine Bone ◽

Graft Material ◽

Hard Tissue ◽

Platelet Rich Fibrin ◽

Tissue Healing ◽

Significant Difference ◽

Time Point

Bone defects lead to aesthetic and functional losses, causing dental rehabilitation to be more difficult. The objective of this work is to histologically assess the hard tissue healing of bone defects filled with platelet-rich fibrin (PRF) alone or as an adjuvant for mixing with and covering anorganic bovine bone (ABB), compared to ABB covered with a resorbable collagen membrane (CM). This study was designed as a crossover animal study. Four 5-mm tibia defects, 5 mm apart from each other, were surgically created on the tibias of 6 sheep. The defects were randomly filled with ABB + CM; PRF alone; ABB+PRF; or were left empty. The animals were euthanized on days 10, 20, and 40 post-operatively. No group showed any signs of bone necrosis. Inflammation was observed in 2 control and 3 test defects with no statistically significant difference between groups at each time point. The ABB + CM and ABB + PRF groups experienced the highest bone regeneration ratios. No differences between the empty-defect and PRF groups were observed in regard to bone regeneration. No statistical difference was observed between the ABB+PRF and ABB + CM groups in regard to bone regeneration and the amount of residual graft material at each time point. The use of PRF should be preferred due to its autogenous origin, low cost, and ease of use.

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