scholarly journals The Joint Role of Thyroid Function and Iodine Status on Risk of Preterm Birth and Small for Gestational Age: A Population-Based Nested Case-Control Study of Finnish Women

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2573 ◽  
Author(s):  
Alexandra C. Purdue-Smithe ◽  
Tuija Männistö ◽  
Griffith A. Bell ◽  
Sunni L. Mumford ◽  
Aiyi Liu ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Iodine Status ◽  
Unit Increase ◽  
Nested Case Control ◽  
Control Study

Normal maternal thyroid function during pregnancy is essential for fetal development and depends upon an adequate supply of iodine. Little is known about how iodine status is associated with preterm birth and small for gestational age (SGA) in mildly iodine insufficient populations. Our objective was to evaluate associations of early pregnancy serum iodine, thyroglobulin (Tg), and thyroid-stimulating hormone (TSH) with odds of preterm birth and SGA in a prospective, population-based, nested case-control study from all births in Finland (2012–2013). Cases of preterm birth (n = 208) and SGA (n = 209) were randomly chosen from among all singleton births. Controls were randomly chosen from among singleton births that were not preterm (n = 242) or SGA (n = 241) infants during the same time period. Women provided blood samples at 10–14 weeks’ gestation for serum iodide, Tg and TSH measurement. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for preterm birth and SGA. Each log-unit increase in serum iodide was associated with higher odds of preterm birth (adjusted OR = 1.19, 95% CI = 1.02–1.40), but was not associated with SGA (adjusted OR = 1.01, 95% CI = 0.86–1.18). Tg was not associated with preterm birth (OR per 1 log-unit increase = 0.87, 95% CI = 0.73–1.05), but was inversely associated with SGA (OR per log-unit increase = 0.78, 95% CI = 0.65–0.94). Neither high nor low TSH (versus normal) were associated with either outcome. These findings suggest that among Finnish women, iodine status is not related to SGA, but higher serum iodide may be positively associated with preterm birth.

scholarly journals Factor V Leiden as a risk factor for preterm birth - a population-based nested case-control study

2011 ◽  
Vol 9 (1) ◽  
pp. 71-78 ◽  
Author(s):  
L. M. HILTUNEN ◽  
H. LAIVUORI ◽  
A. RAUTANEN ◽  
R. KAAJA ◽  
J. KERE ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preterm Birth ◽  
Case Control Study ◽  
Factor V Leiden ◽  
Population Based ◽  
Case Control ◽  
Factor V ◽  
Nested Case Control ◽  
Control Study

scholarly journals Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21st Newborn Case-Control Study protocol

2019 ◽  
Vol 2 ◽  
pp. 49 ◽  
Author(s):  
Stephen H. Kennedy ◽  
Cesar G. Victora ◽  
Rachel Craik ◽  
Stephen Ash ◽  
Fernando C. Barros ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Phase Ii ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Case Control Study ◽  
Human Growth ◽  
Case Control ◽  
International Standards ◽  
Population Characteristics ◽  
Control Study

Background: INTERBIO-21st is Phase II of the INTERGROWTH-21st Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. Methods: In the INTERBIO-21st Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sites, population characteristics, study design, methodology and standardization procedures for the collection of longitudinal clinical data and biological samples (maternal blood, umbilical cord blood, placental tissue, maternal feces and infant buccal swabs) for the study that was conducted between 2012 and 2018 in Brazil, Kenya, Pakistan, South Africa, Thailand and the UK. Discussion: Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. The study should enhance current medical knowledge and provide new insights into environmental influences on human growth and neurodevelopment.

P.44 FV Leiden as risk factor for preterm birth – a population-based nested case-control study

2011 ◽  
Vol 127 ◽  
pp. S140
Author(s):  
L. Hiltunen ◽  
H. Laivuori ◽  
A. Rautanen ◽  
R. Kaaj ◽  
J. Kere ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preterm Birth ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Fv Leiden ◽  
Nested Case Control ◽  
Control Study

scholarly journals Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21st Newborn Case-Control Study protocol

2018 ◽  
Vol 2 ◽  
pp. 49 ◽  
Author(s):  
Stephen H. Kennedy ◽  
Cesar G. Victora ◽  
Rachel Craik ◽  
Stephen Ash ◽  
Fernando C. Barros ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Phase Ii ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Case Control Study ◽  
Human Growth ◽  
Case Control ◽  
International Standards ◽  
Population Characteristics ◽  
Control Study

Background: INTERBIO-21st is Phase II of the INTERGROWTH-21st Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age. Methods: In the INTERBIO-21st Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sites, population characteristics, study design, methodology and standardization procedures for the collection of longitudinal clinical data and biological samples (maternal blood, umbilical cord blood, placental tissue, maternal feces and infant buccal swabs) for the study that was conducted between 2012 and 2018 in Brazil, Kenya, Pakistan, South Africa, Thailand and the UK. Discussion: Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. The study should enhance current medical knowledge and provide new insights into environmental influences on human growth and neurodevelopment.

Sign in / Sign up

Export Citation Format

Share Document