scholarly journals Nutritional Support in Patients with Severe Acute Pancreatitis-Current Standards

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1498
Author(s):  
Beata Jabłońska ◽  
Sławomir Mrowiec
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Infectious Complications ◽  
Nutritional Risk ◽  
Gastrointestinal Dysmotility ◽  
Gut Barrier Function ◽  
Nasojejunal Tube ◽  
Nutritional Disturbances ◽  
Current Standards

Severe acute pancreatitis (SAP) leads to numerous inflammatory and nutritional disturbances. All SAP patients are at a high nutritional risk. It has been proven that proper nutrition significantly reduces mortality rate and the incidence of the infectious complications in SAP patients. According to the literature, early (started within 24–48 h) enteral nutrition (EN) is optimal in most patients. EN protects gut barrier function because it decreases gastrointestinal dysmotility secondary to pancreatic inflammation. Currently, the role of parenteral nutrition (PN) in SAP patients is limited to patients in whom EN is not possible or contraindicated. Early versus delayed EN, nasogastric versus nasojejunal tube for EN, EN versus PN in SAP patients and the role of immunonutrition (IN) in SAP patients are discussed in this review.

scholarly journals Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis

2020 ◽  
Vol 24 (17) ◽  
pp. 9774-9785
Author(s):  
Jing Wang ◽  
Jun Tian ◽  
Yang‐huan He ◽  
Zhi‐wen Yang ◽  
Lin Wang ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Peritoneal Macrophages ◽  
Signal Pathway

Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis

2011 ◽  
Vol 90 (5) ◽  
pp. 975-982 ◽  
Author(s):  
Aree Abdulla ◽  
Darbaz Awla ◽  
Henrik Thorlacius ◽  
Sara Regnér
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis

scholarly journals A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotising pancreatitis in rabbits

Gut ◽  
1998 ◽  
Vol 43 (2) ◽  
pp. 232-239 ◽  
Author(s):  
M O Osman ◽  
J U Kristensen ◽  
N O Jacobsen ◽  
S B Lausten ◽  
B Deleuran ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Interleukin 8 ◽  
Systemic Complications ◽  
Duct Ligation ◽  
Tnf Α

Background—Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis.Aims—To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbit model of severe acute pancreatitis.Methods—Acute pancreatitis was induced by retrograde injection of 5% chenodeoxycholic acid into the pancreatic duct and duct ligation. Twenty rabbits were divided equally into two groups: acute pancreatitis controls received physiological saline and the treated group received WS-4, 30 minutes before induction of acute pancreatitis.Results—Pretreatment of animals with WS-4 resulted in significant down regulation of serum IL-8 and tumour necrosis factor α (TNF-α) from three to six hours after induction of acute pancreatitis (p=0.011 and 0.047 for IL-8 and 0.033 and 0.022 for TNF-α, respectively). In addition, a significant reduction in the CD11b and CD18 positive cells and the amount of interstitial neutrophil infiltration in the lungs from WS-4 treated animals was seen. In contrast, WS-4 did not alter the amount of pancreatic necrosis and the serum concentrations of amylase, lipase, calcium, and glucose.Conclusion—WS-4 cannot change the amount of pancreatic necrosis induced by injection of 5% bile acid, but does reduce the acute lung injury, presumably through inhibition of circulating IL-8 and TNF-α, and CD11b/CD18 in lung tissue. Therefore, a role of IL-8 in the progression of acute pancreatitis and the development of its systemic complications is suggested.

ENTERAL NUTRITION WITH NASOGASTRIC VS NASOJEJUNAL TUBE IN SEVERE ACUTE PANCREATITIS: A PRAGMATIC STUDY

2009 ◽  
Vol 41 ◽  
pp. S101
Author(s):  
M. Piciucchi ◽  
E. Merola ◽  
M. Marignani ◽  
F. Panzuto ◽  
F. Baccini ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Enteral Nutrition ◽  
Severe Acute Pancreatitis ◽  
Nasojejunal Tube ◽  
Pragmatic Study
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