Supercritical Fluid Processing of Polymers

The use of supercritical fluids instead of organic solvents has attracted the interest of numerous researchers, due to the unique peculiarities of supercritical fluids which are characterized by solvent powers comparable to those of liquid organic solvents, diffusivity comparable to those of gaseous substances and quasi-zero surface tension [...]

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Squalene Extraction by Supercritical Fluids from Traditionally Puffed Amaranthus hypochondriacus Seeds

Journal of Food Quality ◽

10.1155/2017/6879712 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Teresa Rosales-García ◽

Cristian Jiménez-Martínez ◽

Anaberta Cardador-Martínez ◽

Sandra Teresita Martín-del Campo ◽

Luis A. Galicia-Luna ◽

...

Keyword(s):

Fatty Acids ◽

Supercritical Fluid Extraction ◽

Organic Solvents ◽

Supercritical Fluid ◽

Supercritical Fluids ◽

Seed Morphology ◽

Natural Antioxidant ◽

Amaranthus Hypochondriacus ◽

Squalene Content ◽

Soxhlet Method

Extraction of squalene, a potent natural antioxidant, from puffed A. hypochondriacus seeds was performed by supercritical fluid extraction (SCFE); besides, to have a blank for comparison, extraction was performed also by Soxhlet method using organic solvents (hexane). Chemical proximal composition and seed morphology were determined in raw, puffed, and SCFE-extracted seeds. Extracts were obtained with a 500 mL capacity commercial supercritical extractor and performed between 10 and 30 MPa at 313, 323, and 333 K under constant CO2 flow of 0.18 kg CO2/h during 8 h. The squalene content was determined and the fatty acids present in the extracts were identified by GC-MS. The extract obtained by SCFE from puffed amaranth seeds reached 460 ± 28.1 g/kg squalene in oily extract at 313 K/20 MPa.

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Supercritical Solvent Impregnation in Controlled-Release Drugs

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.152-153.1462 ◽

2010 ◽

Vol 152-153 ◽

pp. 1462-1465

Author(s):

Zhen Tian ◽

Nai Ci Bing ◽

Ye Zhang ◽

Ling Ling Wang ◽

Wei Qiao

Keyword(s):

Controlled Release ◽

Organic Solvents ◽

Supercritical Fluid ◽

Supercritical Fluids ◽

Elevated Temperatures ◽

Amorphous Polymers ◽

Bioactive Molecules ◽

Supercritical Solvent ◽

Supercritical Fluid Technology ◽

Toxic Organic Solvents

In the field of pharmaceutical industry, the controlled-release drugs have received considerable attention in the last years. Impregnation using supercritical fluid technology has already proven its feasibility in the preparation of controlled release systems. The use of supercritical fluids such as supercritical CO2 has provided a ‘clean’ and effective alternative to traditional methods of drug releasing and polymer processes. In particular, scCO2 has a number of unique properties that make it possible to process both bioactive molecules and amorphous polymers without using toxic organic solvents or elevated temperatures. A high purity product, free of residual solvents is obtained, since no organic solvents are involved in the impregnation process. Here, we review the advantages of supercritical fluid and the preparation of controlled-release drugs by supercritical solvent impregnation.

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