Faculty Opinions recommendation of Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

2006 ◽  
Author(s):  
Marc Caron
Keyword(s):  
Adrenergic Receptor ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Gamma Secretase ◽  
Secretase Activity

Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation

2006 ◽  
Vol 12 (12) ◽  
pp. 1390-1396 ◽  
Author(s):  
Yanxiang Ni ◽  
Xiaohui Zhao ◽  
Guobin Bao ◽  
Lin Zou ◽  
Lin Teng ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Secretase Activity ◽  
Β2 Adrenergic Receptor

scholarly journals Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

Biology Open ◽  
2020 ◽  
pp. bio.054627
Author(s):  
Wayne M. Jepsen ◽  
Matthew De Both ◽  
Ashley L. Siniard ◽  
Keri Ramsey ◽  
Ignazio S. Piras ◽  
...  
Keyword(s):  
Adenosine Triphosphate ◽  
Organic Anion ◽  
Amyloid Plaque ◽  
Organic Anion Transporter ◽  
Gamma Secretase ◽  
App Processing ◽  
Anion Transporter ◽  
Secretase Activity ◽  
Beta Secretase

The organic anion transporter Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood-brain barrier to the periphery, and that pharmaceutical activation of ABCC1 can reduce amyloid plaque deposition in the brain. Here, we show that ABCC1 is not only capable of exporting Abeta from the cytoplasm of human cells, but also that it's overexpression significantly reduces Abeta production and increases the ratio of alpha- versus beta-secretase mediated cleavage of the Amyloid Precursor Protein (APP), likely via indirect modulation of alpha-, beta-, and gamma-secretase activity.

scholarly journals Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

2020 ◽  
Author(s):  
Wayne M. Jepsen ◽  
Matthew De Both ◽  
Ashley L. Siniard ◽  
Keri Ramsey ◽  
Ignazio S. Piras ◽  
...  
Keyword(s):  
Adenosine Triphosphate ◽  
Organic Anion ◽  
Amyloid Plaque ◽  
Organic Anion Transporter ◽  
Gamma Secretase ◽  
App Processing ◽  
Anion Transporter ◽  
Secretase Activity ◽  
Beta Secretase

AbstractThe organic anion transporter Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer’s disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood-brain barrier to the periphery, and that pharmaceutical activation of ABCC1 can reduce amyloid plaque deposition in the brain. Here, we show that ABCC1 is not only capable of exporting Abeta from the cytoplasm of human cells, but also that it’s overexpression significantly reduces Abeta production and increases the ratio of alpha- versus beta-secretase mediated cleavage of the Amyloid Precursor Protein (APP), likely via indirect modulation of alpha-, beta-, and gamma-secretase activity.

scholarly journals Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

2014 ◽  
Vol 35 (1) ◽  
pp. 213-222 ◽  
Author(s):  
Mikiko Ohno ◽  
Yoshinori Hiraoka ◽  
Stefan F. Lichtenthaler ◽  
Kiyoto Nishi ◽  
Sayaka Saijo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Plaque ◽  
Plaque Formation ◽  
Secretase Activity
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