Faculty Opinions recommendation of Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions.

2002 ◽  
Author(s):  
Stanley Froehner
Keyword(s):  
Nmda Receptor ◽  
Brain Damage ◽  
Protein Interactions ◽  
Ischemic Brain Damage ◽  
Ischemic Brain

scholarly journals Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 ◽  
Vol 8 (1) ◽  
pp. 138-143 ◽  
Author(s):  
E. Ozyurt ◽  
D. I. Graham ◽  
G. N. Woodruff ◽  
J. McCulloch
Keyword(s):  
Cerebral Ischemia ◽  
Nmda Receptor ◽  
Middle Cerebral Artery ◽  
Brain Damage ◽  
Cerebral Artery ◽  
Focal Cerebral Ischemia ◽  
Ischemic Damage ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Mk 801

The effects of the glutamate N-methyl-D aspartate (NMDA) receptor antagonist, MK-801, upon ischemic brain damage has been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of one middle cerebral artery and the animals were killed 6 h later. The amount of early ischemic damage was assessed in coronal sections at 16 predetermined stereotactic planes. Pretreatment with MK-801 (5 mg/kg, i.v.), 30 min before occlusion of the middle cerebral artery significantly reduced the volume of ischemic damage (from 32.7 ± 4.0% of the cerebral hemisphere in vehicle-treated cats to 16.2 ± 4.5% in MK-801-treated cats). NMDA receptor antagonists that penetrate the blood-brain barrier, such as MK-801, merit further study as protective agents against ischemic brain damage.

scholarly journals Focal Cerebral Ischemia in the Cat: Pretreatment with a Competitive NMDA Receptor Antagonist, D-CPP-ene

1990 ◽  
Vol 10 (5) ◽  
pp. 668-674 ◽  
Author(s):  
Ross Bullock ◽  
David I. Graham ◽  
Min-Hsiung Chen ◽  
David Lowe ◽  
James McCulloch
Keyword(s):  
Cerebral Ischemia ◽  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Brain Damage ◽  
Cerebral Hemisphere ◽  
Focal Cerebral Ischemia ◽  
Nmda Receptor Antagonist ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Permanent Occlusion

The effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-( E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPP-ene; SDZ EAA 494) upon ischemic brain damage have been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of the middle cerebral artery (MCA) and the animals were killed 6 h later. The amount of early ischemic brain damage was assessed in coronal sections at 16 predetermined stereotaxic planes. Pretreatment with D-CPP-ene (15 mg/kg i.v. followed by continuous infusion at 0.17 mg/kg/min until death), 15 min prior to MCA occlusion, significantly reduced the volume of ischemic brain damage (from 20.6 ± 9.9% of the cerebral hemisphere in vehicle-treated cats to 7.2 ± 4.4% in drug-treated cats; p < 0.01). The competitive NMDA receptor antagonist D-CPP-ene is as effective as noncompetitive NMDA antagonists in reducing the amount of ischemic brain damage in this model of focal cerebral ischemia in a gyrencephalic species.

Blockade of central histaminergic H2 receptors facilitates catecholaminergic metabolism and aggravates ischemic brain damage in the rat telencephalon

2003 ◽  
Vol 974 (1-2) ◽  
pp. 117-126 ◽  
Author(s):  
Ryu Otsuka ◽  
Naoto Adachi ◽  
Gen Hamami ◽  
Keyue Liu ◽  
Toshihiro Yorozuya ◽  
...  
Keyword(s):  
Brain Damage ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
H2 Receptors
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