Faculty Opinions recommendation of Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons.

2004 ◽  
Author(s):  
Alexandra Joyner
Keyword(s):  
Sensory Neurons ◽  
Nuclear Transfer ◽  
Odorant Receptor ◽  
Receptor Gene ◽  
Olfactory Sensory Neurons

Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons

Nature ◽  
2004 ◽  
Vol 428 (6981) ◽  
pp. 393-399 ◽  
Author(s):  
Jinsong Li ◽  
Tomohiro Ishii ◽  
Paul Feinstein ◽  
Peter Mombaerts
Keyword(s):  
Sensory Neurons ◽  
Nuclear Transfer ◽  
Odorant Receptor ◽  
Receptor Gene ◽  
Olfactory Sensory Neurons

scholarly journals Widespread inhibition, antagonism, and synergy in mouse olfactory sensory neurons in vivo

2019 ◽  
Author(s):  
Shigenori Inagaki ◽  
Ryo Iwata ◽  
Masakazu Iwamoto ◽  
Takeshi Imai
Keyword(s):  
Sensory Neurons ◽  
Calcium Imaging ◽  
Odorant Receptor ◽  
Sensory Information ◽  
Olfactory Sensory Neurons ◽  
Axon Terminals ◽  
Two Photon ◽  
Odor Mixtures ◽  
The Brain

SUMMARYSensory information is selectively or non-selectively inhibited and enhanced in the brain, but it remains unclear whether this occurs commonly at the peripheral stage. Here, we performed two-photon calcium imaging of mouse olfactory sensory neurons (OSNs) in vivo and found that odors produce not only excitatory but also inhibitory responses at their axon terminals. The inhibitory responses remained in mutant mice, in which all possible sources of presynaptic lateral inhibition were eliminated. Direct imaging of the olfactory epithelium revealed widespread inhibitory responses at OSN somata. The inhibition was in part due to inverse agonism toward the odorant receptor. We also found that responses to odor mixtures are often suppressed or enhanced in OSNs: Antagonism was dominant at higher odor concentrations, whereas synergy was more prominent at lower odor concentrations. Thus, odor responses are extensively tuned by inhibition, antagonism, and synergy, at the early peripheral stage, contributing to robust odor representations.

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