Faculty Opinions recommendation of Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development.

ABSTRACT Yeast strains were constructed carrying multiple mitochondrial markers conferring resistance to the inhibitors erythromycin, chloramphenicol, paromomycin and oligomycin. A pedigree analysis of two crosses was made by micromanipulating buds from zygotes. The first few daughter buds isolated from the zygotes sometimes gave rise to diploid clones which had a mixture of mitochondrial types. All possible classes of mitochondrial parental and recombinant types were found although they never appeared all together as the progeny from a single zygote. It was inferred that multiple recombination events took place in zygotes and in some of the buds derived from them. After removal of the first four or so daughter buds, subsequent buds from the zygote carried one mitochondrial type only. In cross I in which three markers were analyzed this was most frequently one of the parental types. In cross II (involving four mitochondrial markers) the later buds from the zygotes were frequently of recombinant mitochondrial type.

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The genetic analysis of the vulval cell lineages of Caenorhabditis elegans

10.1575/1912/3135 ◽

1985 ◽

Cited By ~ 2

Author(s):

Edwin Louis Ferguson

Keyword(s):

Caenorhabditis Elegans ◽

Genetic Analysis ◽

Cell Lineages

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The molecular and genetic analysis of mouse development

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1992.tb16599.x ◽

1992 ◽

Vol 204 (1) ◽

pp. 5-11 ◽

Cited By ~ 4

Author(s):

Achim GOSSLER ◽

Rudi BALLING

Keyword(s):

Genetic Analysis ◽

Mouse Development

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Genetic analysis of developmental mechanisms in hydra. VI. Cellular composition of chimera hydra

Journal of Cell Science ◽

10.1242/jcs.35.1.1 ◽

1979 ◽

Vol 35 (1) ◽

pp. 1-15

Author(s):

T. Sugiyama ◽

T. Fujisawa

Keyword(s):

Epithelial Cell ◽

Genetic Analysis ◽

Interstitial Cell ◽

Cell Types ◽

Interstitial Cells ◽

Cellular Composition ◽

Feedback Mechanisms ◽

Cell Lineages ◽

Developmental Mechanisms ◽

Homeostatic Mechanisms

The homeostatic mechanisms that maintain constant cellular ratios in hydra tissue were studied using mutant and chimeric hydra strains. Mutants having abnormal cellular compositions are isolated through sexual inbreeding of wild hydra, as described in previous papers of this series. Chimeric hydra are produced by making use of a strain (nf-I) which lacks interstitial cells, nerve cells and nematocytes in its tissue. Reintroduction of interstitial cells from other strains (both normal and mutant) into nf-I leads to creation of chimeric strains having epithelial cell lineages from one strain (nf-I) and interstitial cell lineages from others. Analyses and comparisons of the cellular compositions of all these strains revealed that the numbers of nerve or interstitial cells in the chimeras were very similar to (statistically significantly correlated with) those in their interstitial cell donors. Since chimeras and their interstitial cell donors share the same interstitial cell lineages, this suggests that interstitial cells or their derivatives (nerves and nematocytes) play major roles in determining the nerve and interstitial cell levels in the hydra tissue. It is suggested that some form of homeostatic feedback mechanisms are probably involved in regulating the levels of these cell types.

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Genetic analysis of specific and redundant roles for p38 and p38 MAPKs during mouse development

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1015013108 ◽

2011 ◽

Vol 108 (31) ◽

pp. 12764-12769 ◽

Cited By ~ 30

Author(s):

I. del Barco Barrantes ◽

J. M. Coya ◽

F. Maina ◽

J. S. C. Arthur ◽

A. R. Nebreda

Keyword(s):

Genetic Analysis ◽

Mouse Development ◽

P38 Mapks

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The genetic analysis of cell lineage in Caenorhabditis elegans

Philosophical Transactions of the Royal Society of London Series B Biological Sciences ◽

10.1098/rstb.1985.0182 ◽

1985 ◽

Vol 312 (1153) ◽

pp. 129-137 ◽

Cited By ~ 1

Keyword(s):

Caenorhabditis Elegans ◽

Genetic Analysis ◽

Genetic Control ◽

Cell Lineage ◽

Cell Lineages ◽

Genetic Programme

The genetic control of cell lineage has been studied extensively in Caenorhabditis elegans . In this paper, three studies of cell lineage mutants are reviewed: the isolation of mutations affecting vulval cell lineages, and the analysis of two ‘control genes’, lin -12 and lin -14. In addition, certain logical features of the genetic programme, as inferred from or illuminated by the study of cell lineage mutants, are discussed: the concepts of ‘ control genes ’ and developmental subprogrammes, and the organization of the lineage into a hierarchy of binary decisions.

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