Faculty Opinions recommendation of Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation.

2004 ◽  
Author(s):  
L. Alison McInnes
Keyword(s):  
Alternative Splicing ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Term Potentiation

scholarly journals Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation

2003 ◽  
Vol 9 (2) ◽  
pp. 174-183 ◽  
Author(s):  
I Nijholt ◽  
N Farchi ◽  
M Kye ◽  
E H Sklan ◽  
S Shoham ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Term Potentiation

scholarly journals The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Leanne J M Schmitz ◽  
Remco V Klaassen ◽  
Marta Ruiperez-Alonso ◽  
Azra Elia Zamri ◽  
Jasper Stroeder ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Synaptic Function ◽  
Glutamatergic Synapses ◽  
Contextual Fear ◽  
Receptor Associated Protein ◽  
Term Potentiation ◽  
Bona Fide

Glutamatergic synapses rely on AMPA receptors (AMPARs) for fast synaptic transmission and plasticity. AMPAR auxiliary proteins regulate receptor trafficking, and modulate receptor mobility and its biophysical properties. The AMPAR auxiliary protein Shisa7 (CKAMP59) has been shown to interact with AMPARs in artificial expression systems, but it is unknown whether Shisa7 has a functional role in glutamatergic synapses. We show that Shisa7 physically interacts with synaptic AMPARs in mouse hippocampus. Shisa7 gene deletion resulted in faster AMPAR currents in CA1 synapses, without affecting its synaptic expression. Shisa7 KO mice showed reduced initiation and maintenance of long-term potentiation of glutamatergic synapses. In line with this, Shisa7 KO mice showed a specific deficit in contextual fear memory, both short-term and long-term after conditioning, whereas auditory fear memory and anxiety-related behavior were normal. Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memory recall.

scholarly journals cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala

2007 ◽  
Vol 7 (S1) ◽  
Author(s):  
Cindy Paul ◽  
Pascal Weinmeister ◽  
Robert Feil ◽  
Franz Hofmann ◽  
Thomas Kleppisch
Keyword(s):  
Long Term Potentiation ◽  
Fear Memory ◽  
Lateral Amygdala ◽  
Term Potentiation

scholarly journals Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

2012 ◽  
Vol 72 (3) ◽  
pp. 182-190 ◽  
Author(s):  
Hanoch Kaphzan ◽  
Pepe Hernandez ◽  
Joo In Jung ◽  
Kiriana K. Cowansage ◽  
Katrin Deinhardt ◽  
...  
Keyword(s):  
Angelman Syndrome ◽  
Memory Deficits ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Term Potentiation

scholarly journals Involvement of Cerebellum in Emotional Behavior

2011 ◽  
pp. S39-S48 ◽  
Author(s):  
P. STRATA ◽  
B. SCELFO ◽  
B. SACCHETTI
Keyword(s):  
Long Term Potentiation ◽  
Fear Memory ◽  
Emotional Behavior ◽  
Fear Learning ◽  
Inhibitory Synapses ◽  
Reversible Inactivation ◽  
Sensory Stimuli ◽  
Term Potentiation ◽  
Reported Data

In the last decade a growing body of data revealed that the cerebellum is involved in the regulation of the affective reactions as well as in forming the association between sensory stimuli and their emotional values. In humans, cerebellar areas around the vermis are activated during mental recall of emotional personal episodes and during learning of a CS-US association. Lesions of the cerebellar vermis may affect retention of a fear memory without altering baseline motor/autonomic responses to the frightening stimuli in both human and animal models. Reversible inactivation of the vermis during the consolidation period impairs retention of fear memory in rodents. Recent findings demonstrate that long-term potentiation (LTP) of synapses in the cerebellar cortex occurs in relation to associative fear learning similar to previously reported data in the hippocampus and amygdala. Plastic changes affect both excitatory and inhibitory synapses. This concomitant potentiation allows the cerebellar cortical network to detect coincident inputs, presumably conveying sensorial stimuli, with better efficacy by keeping the time resolution of the system unchanged. Collectively, these data suggest that the vermis participates in forming new CS-US association and translate an emotional state elaborated elsewhere into autonomic and motor responses.

scholarly journals The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala

2007 ◽  
Vol 61 (9) ◽  
pp. 1049-1061 ◽  
Author(s):  
Surojit Paul ◽  
Peter Olausson ◽  
Deepa V. Venkitaramani ◽  
Irina Ruchkina ◽  
Timothy D. Moran ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Lateral Amygdala ◽  
Protein Tyrosine ◽  
Term Potentiation

scholarly journals Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory

Neuron ◽  
2005 ◽  
Vol 47 (6) ◽  
pp. 859-872 ◽  
Author(s):  
Ming-Gao Zhao ◽  
Hiroki Toyoda ◽  
Yong-Seok Lee ◽  
Long-Jun Wu ◽  
Shanelle W. Ko ◽  
...  
Keyword(s):  
Long Term Potentiation ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Term Potentiation
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