scholarly journals cGMP-dependent kinase I supports formation of associative fear memory and long-term potentiation in the lateral amygdala

2007 ◽  
Vol 7 (S1) ◽  
Author(s):  
Cindy Paul ◽  
Pascal Weinmeister ◽  
Robert Feil ◽  
Franz Hofmann ◽  
Thomas Kleppisch
Keyword(s):  
Long Term Potentiation ◽  
Fear Memory ◽  
Lateral Amygdala ◽  
Term Potentiation

scholarly journals The Striatal-Enriched Protein Tyrosine Phosphatase Gates Long-Term Potentiation and Fear Memory in the Lateral Amygdala

2007 ◽  
Vol 61 (9) ◽  
pp. 1049-1061 ◽  
Author(s):  
Surojit Paul ◽  
Peter Olausson ◽  
Deepa V. Venkitaramani ◽  
Irina Ruchkina ◽  
Timothy D. Moran ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Lateral Amygdala ◽  
Protein Tyrosine ◽  
Term Potentiation

scholarly journals The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Leanne J M Schmitz ◽  
Remco V Klaassen ◽  
Marta Ruiperez-Alonso ◽  
Azra Elia Zamri ◽  
Jasper Stroeder ◽  
...  
Keyword(s):  
Ampa Receptors ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Synaptic Function ◽  
Glutamatergic Synapses ◽  
Contextual Fear ◽  
Receptor Associated Protein ◽  
Term Potentiation ◽  
Bona Fide

Glutamatergic synapses rely on AMPA receptors (AMPARs) for fast synaptic transmission and plasticity. AMPAR auxiliary proteins regulate receptor trafficking, and modulate receptor mobility and its biophysical properties. The AMPAR auxiliary protein Shisa7 (CKAMP59) has been shown to interact with AMPARs in artificial expression systems, but it is unknown whether Shisa7 has a functional role in glutamatergic synapses. We show that Shisa7 physically interacts with synaptic AMPARs in mouse hippocampus. Shisa7 gene deletion resulted in faster AMPAR currents in CA1 synapses, without affecting its synaptic expression. Shisa7 KO mice showed reduced initiation and maintenance of long-term potentiation of glutamatergic synapses. In line with this, Shisa7 KO mice showed a specific deficit in contextual fear memory, both short-term and long-term after conditioning, whereas auditory fear memory and anxiety-related behavior were normal. Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity, and memory recall.

scholarly journals Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation

2010 ◽  
Vol 17 (10) ◽  
pp. 489-493 ◽  
Author(s):  
S. C. Lazzaro ◽  
M. Hou ◽  
C. Cunha ◽  
J. E. LeDoux ◽  
C. K. Cain
Keyword(s):  
Fear Conditioning ◽  
Adrenergic Receptors ◽  
Long Term Potentiation ◽  
Lateral Amygdala ◽  
Term Potentiation

scholarly journals Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation

2003 ◽  
Vol 9 (2) ◽  
pp. 174-183 ◽  
Author(s):  
I Nijholt ◽  
N Farchi ◽  
M Kye ◽  
E H Sklan ◽  
S Shoham ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Term Potentiation
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