Faculty Opinions recommendation of Testing electrostatic complementarity in enzyme catalysis: hydrogen bonding in the ketosteroid isomerase oxyanion hole.

2006 ◽  
Author(s):  
Arieh Warshel
Keyword(s):  
Hydrogen Bonding ◽  
Enzyme Catalysis ◽  
Ketosteroid Isomerase ◽  
Oxyanion Hole

scholarly journals Testing Electrostatic Complementarity in Enzyme Catalysis: Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

PLoS Biology ◽  
2006 ◽  
Vol 4 (4) ◽  
pp. e99 ◽  
Author(s):  
Daniel A Kraut ◽  
Paul A Sigala ◽  
Brandon Pybus ◽  
Corey W Liu ◽  
Dagmar Ringe ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Enzyme Catalysis ◽  
Ketosteroid Isomerase ◽  
Oxyanion Hole

scholarly journals Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

2008 ◽  
Vol 130 (41) ◽  
pp. 13696-13708 ◽  
Author(s):  
Paul A. Sigala ◽  
Daniel A. Kraut ◽  
Jose M. M. Caaveiro ◽  
Brandon Pybus ◽  
Eliza A. Ruben ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Active Site ◽  
Ketosteroid Isomerase ◽  
Oxyanion Hole ◽  
Enzyme Active Site

The unique functional role of the C–H⋯S hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase

2016 ◽  
Vol 12 (8) ◽  
pp. 2408-2416 ◽  
Author(s):  
Ravikumar Reddi ◽  
Kiran Kumar Singarapu ◽  
Debnath Pal ◽  
Anthony Addlagatta
Keyword(s):  
Hydrogen Bonding ◽  
Enzyme Catalysis ◽  
Functional Role ◽  
Methionine Aminopeptidase ◽  
Recognition Specificity ◽  
Hydrogen Bonding Interactions ◽  
Polar Interactions ◽  
Aminopeptidase P

Unique C–H⋯S hydrogen bonding interactions allow nature to attain recognition specificity between molecular interfaces where there is no apparent scope for classical hydrogen bonding or polar interactions.

scholarly journals Proton Affinity of the Oxyanion Hole in the Active Site of Ketosteroid Isomerase

Biochemistry ◽  
2010 ◽  
Vol 49 (12) ◽  
pp. 2725-2731 ◽  
Author(s):  
William Childs ◽  
Steven G. Boxer
Keyword(s):  
Proton Affinity ◽  
Active Site ◽  
Ketosteroid Isomerase ◽  
Oxyanion Hole

Hydrogen Bonding at the Active Site of Δ5-3-Ketosteroid Isomerase†

Biochemistry ◽  
1997 ◽  
Vol 36 (48) ◽  
pp. 14616-14626 ◽  
Author(s):  
Qinjian Zhao ◽  
Chitrananda Abeygunawardana ◽  
Apostolos G. Gittis ◽  
Albert S. Mildvan
Keyword(s):  
Hydrogen Bonding ◽  
Active Site ◽  
Ketosteroid Isomerase

scholarly journals Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase

2011 ◽  
Vol 133 (50) ◽  
pp. 20052-20055 ◽  
Author(s):  
Jason P. Schwans ◽  
Fanny Sunden ◽  
Ana Gonzalez ◽  
Yingssu Tsai ◽  
Daniel Herschlag
Keyword(s):  
Ketosteroid Isomerase ◽  
Oxyanion Hole
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