Faculty Opinions recommendation of Emergence of functional sensory subtypes as defined by transient receptor potential channel expression.

2007 ◽  
Author(s):  
Michaela Kress
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Channel Expression ◽  
Transient Receptor

scholarly journals Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes

2004 ◽  
Vol 170 (10) ◽  
pp. 1101-1107 ◽  
Author(s):  
Naomi Kunichika ◽  
Judd W. Landsberg ◽  
Ying Yu ◽  
Hideki Kunichika ◽  
Patricia A. Thistlethwaite ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Channel Expression ◽  
Transient Receptor ◽  
Vascular Myocytes

Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity

2006 ◽  
Vol 291 (3) ◽  
pp. R518-R529 ◽  
Author(s):  
Martin Wechselberger ◽  
Chadwick L. Wright ◽  
Georgia A. Bishop ◽  
Jack A. Boulant
Keyword(s):  
Transient Receptor Potential ◽  
Neuronal Cell ◽  
Receptor Potential ◽  
Transient Receptor Potential Channel ◽  
Ionic Channels ◽  
Temperature Sensitive ◽  
Neuronal Cell Bodies ◽  
Electrophysiological Studies ◽  
Channel Expression ◽  
Transient Receptor

Thermoregulatory responses are partially controlled by the preoptic area and anterior hypothalamus (PO/AH), which contains a mixed population of temperature-sensitive and insensitive neurons. Immunohistochemical procedures identified the extent of various ionic channels in rat PO/AH neurons. These included pacemaker current channels [i.e., hyperpolarization-activated cyclic nucleotide-gated channels (HCN)], background potassium leak channels (TASK-1 and TRAAK), and transient receptor potential channel (TRP) TRPV4. PO/AH neurons showed dense TASK-1 and HCN-2 immunoreactivity and moderate TRAAK and HCN-4 immunoreactivity. In contrast, the neuronal cell bodies did not label for TRPV4, but instead, punctate labeling was observed in traversing axons or their terminal endings. On the basis of these results and previous electrophysiological studies, Hodgkin–Huxley-like models were constructed. These models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons.

Sign in / Sign up

Export Citation Format

Share Document