Faculty Opinions recommendation of Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia.

2007 ◽  
Author(s):  
Marc Rothenberg
Keyword(s):  
Dendritic Cells ◽  
Viral Infection ◽  
Mucous Cell ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor

scholarly journals Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

2007 ◽  
Vol 179 (3) ◽  
pp. i5-i5
Author(s):  
Mitchell H. Grayson ◽  
Dorothy Cheung ◽  
Michelle M. Rohlfing ◽  
Robert Kitchens ◽  
Daniel E. Spiegel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Viral Infection ◽  
Mucous Cell ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor

scholarly journals Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia

2007 ◽  
Vol 204 (11) ◽  
pp. 2759-2769 ◽  
Author(s):  
Mitchell H. Grayson ◽  
Dorothy Cheung ◽  
Michelle M. Rohlfing ◽  
Robert Kitchens ◽  
Daniel E. Spiegel ◽  
...  
Keyword(s):  
T Cells ◽  
Viral Infection ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
Cd4 T Cells ◽  
Mucous Cell ◽  
Airway Hyperreactivity ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor

Respiratory viral infections are associated with an increased risk of asthma, but how acute Th1 antiviral immune responses lead to chronic inflammatory Th2 disease remains undefined. We define a novel pathway that links transient viral infection to chronic lung disease with dendritic cell (DC) expression of the high-affinity IgE receptor (FcεRIα). In a mouse model of virus-induced chronic lung disease, in which Sendai virus triggered a switch to persistent mucous cell metaplasia and airway hyperreactivity after clearance of replicating virus, we found that FceRIa−/− mice no longer developed mucous cell metaplasia. Viral infection induced IgE-independent, type I IFN receptor–dependent expression of FcεRIα on mouse lung DCs. Cross-linking DC FcεRIα resulted in the production of the T cell chemoattractant CCL28. FceRIa−/− mice had decreased CCL28 and recruitment of IL-13–producing CD4+ T cells to the lung after viral infection. Transfer of wild-type DCs to FceRIa−/− mice restored these events, whereas blockade of CCL28 inhibited mucous cell metaplasia. Therefore, lung DC expression of FcεRIα is part of the antiviral response that recruits CD4+ T cells and drives mucous cell metaplasia, thus linking antiviral responses to allergic/asthmatic Th2 responses.

scholarly journals Aggregation of the High-Affinity IgE Receptor FcεRI on Human Monocytes and Dendritic Cells Induces NF-κB Activation

2002 ◽  
Vol 118 (5) ◽  
pp. 830-837 ◽  
Author(s):  
Stefan Kraft ◽  
Natalija Novak ◽  
Thomas Bieber ◽  
Norito Katoh ◽  
Rudolf A. Rupec
Keyword(s):  
Dendritic Cells ◽  
Human Monocytes ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor

Counter regulation of the high affinity IgE receptor, FcεRI, on human airway dendritic cells by IL-4 and IL-10

Allergy ◽  
2009 ◽  
Vol 64 (11) ◽  
pp. 1602-1607 ◽  
Author(s):  
A. Faith ◽  
N. Singh ◽  
E. Chevretton ◽  
D. Roberts ◽  
T. Lee ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Airway ◽  
High Affinity Ige Receptor

scholarly journals Expression of High-Affinity IgE Receptor on Human Peripheral Blood Dendritic Cells in Children

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e32556 ◽  
Author(s):  
Monica Vasudev ◽  
Dorothy S. Cheung ◽  
Hannah Pincsak ◽  
Shun-Hwa Li ◽  
Ke Yan ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor
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